“…Although some studies showed good methodological quality due to their low bias [29,34,35,38,47], the majority were weak because of either high or unclear risk of bias [28, 30-33, 37, 39-46, 48]. Twelve of the 21 studies 21 [29, 31, 33-35, 38, 40, 42, 44, 45, 47, 48] described the method of randomization generation and 11 studies [29,31,34,35,38,41,42,44,45,47,48] used a concealed allocation schedule. The methodological quality of blinding participants and personnel on the assignment of participants to study groups were generally low due to either high or unclear bias in procedures across most studies and insu cient detail.…”