Effectiveness of Granisetron in Prevention of Hypotension Following Spinal Anaesthesia in Patients Undergoing Elective Caesarean Section

Chatterjee, Abhishek; Gudiwada, Bhanu; Mahanty, Pratap Rudra; Himanshu, Kumar; Nag, Deb Sanjay; Ganguly, Pradip; Shukla, Rishabh

doi:10.7759/cureus.12113

Cited by 5 publications

(5 citation statements)

References 22 publications

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“…This research has same result with Abhisek et al which stated that granisetron can reduce the hypotension with incidence result 37% (Chatterjee et al, 2020). Another study of Granisetron by Maheen et al reported same result with incidence of hypotension in 17,5% (Wahid et al, 2022).…”

Section: Discussionsupporting

confidence: 84%

Preventing Hypotension Caused by Spinal Anesthesia in Non Preeclapmtic Pregnancies With Caesarean Section

Radhitya,

Pratama

2023

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Introduction. Caesarean method widely used and become popular among pregnant women. In general, this method mostly used regional anesthesia (spinal, epidural and CSE). However, many reports incidence of complication related to spinal anesthesia after the procedure. Maternal hypotension is the most common complication after spinal anesthesia procedure. Therefore, anesthesiologist need to prevent hypotension during spinal anesthesia in caesarean section. Method. The researcher examines several scientific journals from PubMed, BJA, Elsevier, Cochrane Library and BMC research until 10th August, 2023 for abstracts, conference proceedings, and full-text papers that evaluated prevention of hypotension in non-preeclampsia patients undergoing caesarean delivery under spinal anesthesia. In addition, the researchers examine the research conducted during 2016 to 2023. Result & Analysis. The researchers examine 28 scientific article (11.153 parturient) with 6 different methods to prevent hypotension. It was found that vasopressor is widely used in most research with incidence of hypotension varied from 4%-87,4%. IVCU studies reported the incidence of hypotension in 15,3%-43%. Leg Elevation a non-invasive technique studies reported the incidence of hypotension in 33,3-41,4%. Injection speed adjustment methods resulted incidence of hypotension in Fast injection 50 %-75% and Slow Injection in 36,7%-61%. In addition, granisetron methods diluted in normal saline reported the incidence of hypotension in 17,5%-42%. Low dose spinal anesthesia studies reported incidence of hypotension in 0% - 62,9%. Discussion. From all the research that has been reviewed, vasopressor (Phenylephrine), Leg Elevation and low dose spinal anesthesia could become primary options to prevent hypotension during spinal anesthesia in caesarean section since its effective to prevent hypotension, cost effective, and easy to applied in every medical facility.

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Section: Discussionsupporting

confidence: 84%

Preventing Hypotension Caused by Spinal Anesthesia in Non Preeclapmtic Pregnancies With Caesarean Section

Radhitya,

Pratama

2023

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“…The number of patients to be included in the study was determined by performing power analysis using similar studies as a reference [ 3 , 11 ]. Accordingly, when an alpha value is set at 0.05 and the power value is 90%, there should be at least 70 patients in each group.…”

Section: Methodsmentioning

confidence: 99%

“…Deviation of the uterus to the left, preloading or co-loading of crystalloid or colloid infusion, and using vasopressors such as ephedrine and phenylephrine are some of the various practices that are used to prevent these complications. Phenylephrine has similar effects to ephedrine in the treatment of hypotension; it is associated with less fetal acidosis, nausea, and vomiting [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Does Preoperative Coffee Consumption Prevent Intraoperative Hypotension in Cesarean Section Surgeries?

Talih,

Ulgey,

Şahingöz

et al. 2024

Cureus

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Objective: In this study, we evaluated the effects of a cup of coffee given to patients before surgery in a cesarean section by means of intraoperative hypotension, ephedrine requirement, and the incidence of post-dural puncture headache (PDPH). Methods: A total of 140 patients undergoing elective cesarean section with spinal anesthesia were included in this study. Participants who drank a single cup of filtered coffee two hours before spinal anesthesia were included in the coffee group, and those who drank water were in the control group. In each group, 70 patients were included. Hemodynamic parameters were recorded every three to five minutes after spinal anesthesia. Intraoperative use of ephedrine was recorded. The PDPH was monitored for three days. Results: The incidence of intraoperative hypotension was 48.6% in the coffee group and 71.4% in the control group (p = 0.006). The rate of ephedrine usage (25.7%) was significantly lower in the coffee group (p = 0.001). The incidence of PDPH in the first 24 hours (2.9%) was significantly lower in the coffee group (11.4%). The visual analog scale (VAS) score was similar between groups (p = 0.048, p > 0.05). Conclusions: Consumption of a single cup of coffee before spinal anesthesia reduced the incidence of intraoperative hypotension and the rate of ephedrine usage in cesarean sections.

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“…Among these cardiovascular complications are predominant. Large surveillance studies typically observed an incidence of hypotension of around 33% and bradycardia of about 13% in non-obstetric population [3].…”

Section: Introductionmentioning

confidence: 99%

A Prospective Observational Study of Intravenous Ondansetron and Palonosetron in Attenuating Hypotensive Response Following Spinal Anesthesia in Patients Undergoing Elective Cesarean Section

TIRTHASISH MANDAL,

DEBASRI SARKAR BISWAS,

DEBAYAN BHATTACHARYA

2024

Asian J Pharm Clin Res

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Objective: To compare the efficacy of prophylactic administration of intravenous ondansetron and palonosetron in attenuating hypotensive response following spinal anesthesia in patients undergoing elective cesarean section. Methods: This was a comparative study in which 84 patients aged 18–35 years of American Society of Anesthesiologists physical status II, scheduled for elective cesarean section under spinal anesthesia (SA) were included based on predefined inclusion and exclusion criteria. 84 patients undergoing elective cesarean sections were divided into two groups to receive either ondansetron or palonosetron before SA. Vital signs were monitored, with interventions for hypotension or bradycardia. Data on vital signs, vasopressor use, neonatal Apgar scores, and post-operative symptoms were collected and analyzed. For statistical purposes, a P value less than 0.05 was taken as statistically significant. Results: The mean ages and body mass indexes (BMIs) of the groups were similar, with no significant statistical difference (p=0.674 and p=0.3583, respectively). Heart rates, systolic and diastolic blood pressures showed minor differences, but only a few instances were statistically significant. Mean arterial pressures differed significantly at multiple intervals, but no clinical hypotension was observed. SPO2 levels remained stable and comparable in both groups. Average phenylephrine usage was also similar, with no significant difference. The incidence of hypotension, sedation scores, and incidence of bradycardia were comparable. Neonatal outcomes, measured by APGAR scores, showed no significant difference, indicating similar newborn health status in both groups. Conclusion: Prophylactic ondansetron, as well as palonosetron, were equally effective in reducing the incidence and severity of hypotension in healthy parturients following spinal anesthesia with hyperbaric bupivacaine for elective LSCS.

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Effectiveness of Granisetron in Prevention of Hypotension Following Spinal Anaesthesia in Patients Undergoing Elective Caesarean Section

Cited by 5 publications

References 22 publications

Preventing Hypotension Caused by Spinal Anesthesia in Non Preeclapmtic Pregnancies With Caesarean Section

Preventing Hypotension Caused by Spinal Anesthesia in Non Preeclapmtic Pregnancies With Caesarean Section

Does Preoperative Coffee Consumption Prevent Intraoperative Hypotension in Cesarean Section Surgeries?

A Prospective Observational Study of Intravenous Ondansetron and Palonosetron in Attenuating Hypotensive Response Following Spinal Anesthesia in Patients Undergoing Elective Cesarean Section

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