Effectiveness of fibrin glue in adherence of skin graft

Reddy, Konda Sireesha; Chittoria, Ravi Kumar; Babu, Preethitha; Marimuthu, Senthil Kumaran; Kumar, Sudhanva Hemanth; Subbarayan, Elan Kumar; Chavan, Vinayak; Mohapatra, Devi Prasad; Sivakumar, Dinesh Kumar; Friji, M T

doi:10.4103/jcas.jcas_100_16

Cited by 21 publications

(4 citation statements)

References 14 publications

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“…Only 2 studies in the literature have compared FG versus traditional approaches for STSG fixation in a general reconstructive, nonburn wound patient population. Reddy et al 30 examined a prospective cohort of patients and compared surgical outcomes at 14 days of follow-up between groups whose STSGs were fixated using FG versus skin staples or suture. Despite the small cohort, lack of matched study participants, and short-term follow-up, the group anecdotally noted reduction in operating room duration, better hemostasis, and better graft fixation in the FG group.…”

Section: Discussionmentioning

confidence: 99%

To Glue or Not to Glue? Analysis of Fibrin Glue for Split-thickness Skin Graft Fixation

Mullens

Messa

Kozak

et al. 2019

Plastic and Reconstructive Surgery - Global Open

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Background: Split-thickness skin grafting (STSG) is a commonly used tool in the plastic surgeon’s reconstructive armamentarium. Fibrin glue (FG) consists of a combination of clotting factors and thrombin whose key properties include adherence and hemostasis. This preliminary study aimed to assess clinical outcomes and cost of FG for STSG fixation in a general wound reconstruction. Methods: A retrospective review was conducted in all patients undergoing STSG placement by a single surgeon (JPF) from January 2016 to March 2018. Twenty patients were identified and matched by wound location and wound size. Patients were then divided into 2 groups based on the method of STSG fixation: FG (n = 10) or suture only (SO) (n = 10). Results: In patients with FG fixation, we observed trends of decreased adjusted operative times (34.9 versus 49.4 minutes, P = 0.612), a similar length of stay (2.8 versus 3.5 days, P = 0.306), and liberation from the use of negative pressure wound therapy (0 versus 10 wounds, P < 0.0001). There were no observed differences between the 2 groups in terms of graft-related complications at 180 days (1 complication FG versus 0 complications SO). Time to 100% graft take was also not different (20.2 versus 29.4 days, P = 0.405). Additionally, total direct cost ($16,542 FG versus $24,266 SO; P = 0.545) and total charges ($120,336 FG versus $183,750 SO; P = 0.496) were not statistically different between the FG and SO groups. Conclusions: In this preliminary comparative assessment, FG for STSG fixation has shown no difference in clinical outcomes to SO fixation, trends of decreased operative time, and afforded complete liberation from negative pressure wound therapy dressings.

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Section: Discussionmentioning

confidence: 99%

To Glue or Not to Glue? Analysis of Fibrin Glue for Split-thickness Skin Graft Fixation

Mullens

Messa

Kozak

et al. 2019

Plastic and Reconstructive Surgery - Global Open

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“…The literature search identified 1619 unique abstracts. A total of 151 reports were considered: 46 were subsequently excluded because they assessed split-thickness skin grafts only,[ 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 ] and 14 abstracts could not be accessed—none of which were analytic studies. [ 49 50 51 52 53 54 55 56 57 58 59 60 61 62 ] The final 91 papers studied consisted of 12 analytic studies and 79 descriptive studies (case series, case reports, or expert opinion articles).…”

Section: R Esultsmentioning

confidence: 99%

Full-thickness skin graft fixation techniques: A review of the literature

Steele

Brown

Xie

2020

J Cutan Aesthet Surg

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Multiple techniques for skin graft fixation have been proposed, but the evidence underlying these techniques is unclear. This study aimed to review the literature for full-thickness graft fixation techniques. PubMed was electronically searched to identify relevant studies. The search strategy identified 91 relevant articles. These consisted of 2 randomised controlled trials (RCTs), 10 observational cohort studies (8 retrospective, 2 prospective), and 79 descriptive studies (case series, case reports, or expert opinion articles). Both identified RCTs compared the tie-over dressing against a modified tie-over dressing. The tie-over dressing was also included in all identified observational studies, and comparisons were made against quilting/mattress suturing (4 studies, 181 grafts in total), simple pressure dressings (3 studies, 528 grafts), non-tie-over dressings non-specifically (1 study, 71 grafts), hydrocolloid dressings (1 study, 62 grafts), and double-tie over dressings (1 study, 43 grafts). No significant differences were found between fixation methods for graft take, haematoma rate, and infection rate. No studies have found a significant difference between tie-over dressings and alternative graft fixation technique, with the most evidence for simple pressure dressings and quilting/mattress suturing. However, the evidence base consists mostly of small, retrospective observational studies. This article describes the current evidence base and this should be considered when planning future reports in the field.

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“…В настоящее время фибриновый гель активно используется в клинике для гемостатических целей, закрытия раневой поверхности и в качестве герметика. В ТИ ведутся поиски в области создания фибриновых матриксов в офтальмологии (восстановление склеры [4] и хрусталика [5]), в неврологии (восстановление нервных сплетений и периферических нервов [6]), в травматологии и ортопедии (восстановление хряща [7]), при создании искусственной кожи [8] и т. д. Будучи натуральным физиологическим каркасом, он поддерживает ангиогенез и репарацию тканей [9]. Волокна фибрина содержат сайты клеточной адгезии, которые создают платформу для адгезии, миграции и пролиферации клеток, условия для формирования полноценной ткани [10].…”

Section: Introductionunclassified

Fibrin – a promising material for vascular tissue engineering

Матвеева

Khanova

Антонова

et al. 2020

RJTAO

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This review looks at the use of fibrin in vascular tissue engineering (VTE). Autologous fibrin is one of the most affordable biopolymers because it can be obtained from peripheral blood by simple techniques. A description and comparative analysis of the methods and approaches for producing fibrin gel is provided. The ability of fibrin to promote cell attachment and migration, survival and angiogenesis, to accumulate growth factors and release them in a controlled manner, are unique and extremely useful in VTE. Fibrin gels can serve as a three-dimensional matrix molded in different sizes and shapes to be applied in a variety of ways, including as a scaffold, coating, or impregnation material. Fibrin’s high porosity and biodegradability allows controllable release of growth factors, yet fibrinolysis must be tightly regulated to avoid side effects. We discuss the main methods of regulating the rate of fibrinolysis, as well as possible side effects of such exposure. Low mechanical strength is the main limitation in using fibrin as a scaffold for vascular tissue engineering. Possible options for increasing the strength properties of fibrin matrix and evaluating their effectiveness are presented. We propose that unique biocompatibility and ideal biodegradation profile of fibrin justify its use as a scaffold material for developing an ideal fully autologous small-diameter tissue-engineered vascular graft.

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Effectiveness of fibrin glue in adherence of skin graft

Cited by 21 publications

References 14 publications

To Glue or Not to Glue? Analysis of Fibrin Glue for Split-thickness Skin Graft Fixation

To Glue or Not to Glue? Analysis of Fibrin Glue for Split-thickness Skin Graft Fixation

Full-thickness skin graft fixation techniques: A review of the literature

Fibrin – a promising material for vascular tissue engineering

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