Effectiveness of Eriomin® in managing hyperglycemia and reversal of prediabetes condition: A double‐blind, randomized, controlled study

Abstract

This study evaluated the potential effectiveness of different doses of Eriomin® on hyperglycemia and insulin resistance associated with other metabolic biomarkers in prediabetic individuals. Prediabetes patients ( n = 103, 49 ± 10 years) were randomly divided into four parallel groups: (a) Placebo; (b) Eriomin 200 mg; (c) Eriomin 400 mg; and (d) Eriomin 800 mg. Assessment of biochemical, metabolic, inflammatory, hepatic, renal, anthropometric markers, blood pressure, and dietary parameters were performed during 12 weeks of intervention. Treatment with all doses of Eriomin (200, 400, and 800 mg) had similar effects and altered significantly the following variables: blood glucose (−5%), insulin resistance (−7%), glucose intolerance (−7%), glycated hemoglobin (−2%), glucagon (−6.5%), C‐peptide (−5%), hsCRP (−12%), interleukin‐6 (−13%), TNFα (−11%), lipid peroxidation (−17%), systolic blood pressure (−8%), GLP‐1 (+15%), adiponectin (+19%), and antioxidant capacity (+6%). Eriomin or placebo did not influence the anthropometric and dietary variables. Short‐term intervention with Eriomin, at doses of 200, 400, or 800 mg/day, benefited glycemic control, reduced systemic inflammation and oxidative stress, and reversed the prediabetic condition in 24% of the evaluated patients.

New Insights into the Metabolism of the Flavanones Eriocitrin and Hesperidin: A Comparative Human Pharmacokinetic Study

“…In general, the flavanone amounts administered in human interventions to evaluate hesperidin effects range from 146 to 1000 mg, with an average dose of ~500–600 mg [ 35 ]. Moreover, flavanone effects are usually evaluated for weeks or months [ 36 , 37 ].…”

“…Whereas a recent study showed a reduction of glucose, insulin, triglycerides, cholesterol, LDL-c, and HOMA-IR index after two months of orange juice consumption in females [ 41 ], another study did not observe changes in these markers after a daily dose of 800 mg of hesperidin [ 40 ]. On the other hand, we found only one trial that evaluated the effects of eriocitrin in prediabetic individuals [ 35 ] and reported an improvement of hyperglycemic, inflammatory, and metabolic parameters, but not dose-dependently after consuming 200–800 mg/day eriocitrin for three months [ 35 ]. These results suggest that consistent consumption of lower eriocitrin doses could exert beneficial health effects.…”

New Neuroprotective Effect of Lemon IntegroPectin on Neuronal Cellular Model

“…Hesperidin is being intensively studied also as a preventative and therapeutic agent against the development of various types of metabolic diseases [47]. Lemon-derived eriocitrin, known to increase antioxidant capacity and decrease inflammatory markers in mice [48], is along with hesperidin the main ingredient of a nutraceutical product recently shown to be effective, in a double-blind randomized clinical study, in managing hyperglycemia and reversal of prediabetes condition [49].…”

Redox biomarkers in dietary interventions and nutritional observation studies - From new insights to old problems

“…No effect on redox status was observed after combined supplementation of 190 mg quercetin with 3.6 g α-linolenic acid a day for eight weeks [ 87 ]. A decrease in MDA and an increase in TAC were reported both for different intakes of flavonoid-rich supplement Eriomin® over twelve weeks [ 88 ] and 80 mg curcumin a day for ten weeks [ 89 ]. No effect on redox status of healthy participants was observed for supplementation with 1720 mg DHA and 600 mg EPA daily for 18 months [ 90 ] as well as daily intake of 1500 mg l -carnitine for 24 weeks [ 91 ].…”