Effectiveness of Early Antiviral Therapy in Disseminated Neonatal Herpes Simplex Virus 2 (HSV-2) with Fulminant Hepatic Failure

Abstract

Patient: Male, 11-day-oldFinal Diagnosis: Disseminated neonatal herpes simplex virus-2Symptoms: Feeding problems • lethargy • rashMedication: —Clinical Procedure: —Specialty: Pediatrics and NeonatologyObjective:Unusual clinical courseBackground:Liver failure in the neonatal population is a life-threatening complication and has a wide array of etiologies, including infectious, immune-mediated, metabolic, or drug-induced. Although neonatal herpes simplex virus (HSV) hepatitis only accounts for 1% of all acute liver failures, it has an extremely aggressive clinical course that carries a mortality rate of 85%.Case Report:We report a rare case of disseminated neonatal HSV-2 with late presentation associated with fulminant liver failure. The patient recovered without obvious neurologic deficits or need for liver transplant.Conclusions:This case study emphasizes and promotes awareness of early recognition and appropriate clinical management of neonatal HSV infection, and its positive outcome.