Effectiveness of Dynamic Contrast Enhanced MRI with a Split Dose of Gadoterate Meglumine for Detection of Prostate Cancer

Fan, Xiaobing; Chatterjee, Aritrick; Pittman, Jay M.; Yousuf, Ambereen; Antic, Tatjana; Karczmar, Gregory S.; Oto, Aytekin

doi:10.1016/j.acra.2021.07.028

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…The perfusion parameters of DCE-MRI to reflect the blood perfusion status include BF and BV. BF represents the BF velocity in the blood vessels of the interest area per unit time, and BV represents the BV, both of which mainly reflect blood perfusion and depend on the microvascular density in the tissue ( Arnoldner et al, 2022 ; Chatterjee et al, 2022 ; Fan et al, 2022 ; Nakayama et al, 2022 ). This study showed that DCE-MRI indices were all decreased after ADT, and K trans , K ep , Ve, BF, and BV in the ORR group were lower than those in the non-ORR group, suggesting that DCE-MRI indices may be used to evaluate the efficacy of ADT.…”

Section: Discussionmentioning

confidence: 99%

Clinical efficacy of different androgen deprivation therapies for prostate cancer and evaluation based on dynamic-contrast enhanced magnetic resonance imaging

Guo,

2024

Acta Biochim. Pol.

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ObjectiveTo evaluate the clinical efficacy of different androgen deprivation therapies for prostate cancer (PCa) based on dynamic-contrast enhanced magnetic resonance imaging (DCE-MRI).Methods104 patients with PCa were studied, all of whom were treated with androgen deprivation therapy. The patients were divided into a continuous group (continuous androgen deprivation therapy) and an intermittent group (intermittent androgen deprivation therapy) by random number table method, 52 cases/group. The therapeutic effect and DCE-MRI indices were compared and the relationship between DCE-MRI indices and clinical efficacy and the evaluation value of therapeutic efficacy were analyzed.ResultsThe objective response rate (ORR) of the intermittent group was higher than that of the continuous group (p < 0.05), and there was no significant difference in disease control rate (DCR) between the two groups (p > 0.05). After treatment, volume transfer coefficient (Ktrans), reverse transfer constant (Kep), volume fraction (Ve), blood volume (BV), and blood flow (BF) in both groups were lowered, and those in the intermittent group were lower than the continuous group (p < 0.05). Ktrans, Kep, Ve, BF, and BV in the ORR group were lower than those in the non-ORR group (p < 0.05). Ktrans, Kep, Ve, BF, and BV were correlated with the therapeutic effect of PCa (p < 0.05). The AUC value of the combined detection of DCE-MRI indices in evaluating the therapeutic effect of PCa was greater than that of each index alone (p < 0.05).ConclusionCompared with continuous androgen deprivation therapy, intermittent androgen deprivation therapy has better clinical efficacy in the treatment of PCa, and DCE-MRI indices are related to the treatment efficacy of PCa and have an evaluation value.

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Section: Discussionmentioning

confidence: 99%

Clinical efficacy of different androgen deprivation therapies for prostate cancer and evaluation based on dynamic-contrast enhanced magnetic resonance imaging

Guo,

2024

Acta Biochim. Pol.

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Simple Change Improves the Arterial Input Function in Dynamic Contrast Enhanced MRI

Haney

2022

Academic Radiology

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Efficacy and Safety of Half-Dose Gadopiclenol versus Full-Dose Gadobutrol for Contrast-enhanced Body MRI

et al. 2023

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Effectiveness of Dynamic Contrast Enhanced MRI with a Split Dose of Gadoterate Meglumine for Detection of Prostate Cancer

Cited by 3 publications

References 35 publications

Clinical efficacy of different androgen deprivation therapies for prostate cancer and evaluation based on dynamic-contrast enhanced magnetic resonance imaging

Clinical efficacy of different androgen deprivation therapies for prostate cancer and evaluation based on dynamic-contrast enhanced magnetic resonance imaging

Simple Change Improves the Arterial Input Function in Dynamic Contrast Enhanced MRI

Efficacy and Safety of Half-Dose Gadopiclenol versus Full-Dose Gadobutrol for Contrast-enhanced Body MRI

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