Effectiveness of diffusion tensor imaging in differentiating early-stage subcortical ischemic vascular disease, Alzheimer’s disease and normal ageing

Tu, Manghui; Lo, Cheng‐Hsiang; Huang, Chung-Bin; Hsu, Yen-Hsuan; Huang, Wenhui; Deng, Jie; Lee, Yung-Chuan

doi:10.1371/journal.pone.0175143

Cited by 41 publications

(41 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It should be noted that the white matter alterations extended to frontal fiber tracts such as the anterior thalamic radiation. Alterations in the frontal white matter, including among other regions the anterior thalamic radiation, have been reported previously in late‐onset AD 54,55 . It is thus possible that due to the age difference between autosomal dominant Alzheimer's disesae compared to late onset AD, 13 more frontal white matter alterations are present in late‐onset AD.…”

Section: Discussionmentioning

confidence: 83%

Age‐dependent amyloid deposition is associated with white matter alterations in cognitively normal adults during the adult life span

Caballero

Song

Rubinski

et al. 2020

Alzheimer's & Dementia

View full text Add to dashboard Cite

Introduction Both beta‐amyloid (Ab) deposition and decline in white matter integrity, are brain alterations observed in Alzheimer's disease (AD) and start to occur by the fourth and fifth decades. However, the association between both brain alterations in asymptomatic subjects is unclear. Methods Amyloid positron emission tomography (PET) and diffusion tensor imaging (DTI) were obtained in 282 cognitively normal subjects (age 30‐89 years). We assessed the interaction of age by abnormal amyloid PET status (Florbetapir F‐18 PET >1.2 standard uptake value ratio [SUVR]) on regional mean diffusivity (MD) and global white matter hyperintensity (WMH) volume, controlled for sex, education, and hypertension. Results Subjects with abnormal amyloid PET (n = 87) showed stronger age‐related increase in global WMH and regional MD, particularly within the posterior parietal regions of the white matter. Discussion Sporadic Aβ deposition is associated with white matter alterations in AD predilection areas in an age‐dependent manner in cognitively normal individuals.

show abstract

Section: Discussionmentioning

confidence: 83%

Age‐dependent amyloid deposition is associated with white matter alterations in cognitively normal adults during the adult life span

Caballero

Song

Rubinski

et al. 2020

Alzheimer's & Dementia

View full text Add to dashboard Cite

show abstract

“…A wider distribution of FA modifications than MD was also reported (Wang et al, 2012 ). In addition, some other studies also addressed that FA was a more sensitive measure than other diffusion parameters in differentiating patterns of white matter changes (Tu et al, 2017 ) and the subtype of MCI (Haller et al, 2013 ). Regarding clinical relevancy, our study supported that both FA and MD values can serve as useful biological determinants in terms of cognitive performances, as those relevant microstructural integrity of the genu/body of the corpus callosum and left forceps minor correlated with HRT or HRTSD.…”

Section: Discussionmentioning

confidence: 99%

“…FA and MD values were measured from 19 circular priori-defined subcortical regions of interest (ROI) as the template defined by Tu et al ( 2017 ). The ROI size was kept consistent (30–35 mm 2 ) in all of the subjects in order to obtain a stable number of voxels and decrease variance in the DTI parameters.…”

Section: Methodsmentioning

confidence: 99%

“…In neuroimaging aspects, researchers have identified diffusion tensor image (DTI) to be an useful tool to discern microstructural changes between patients with MCI/AD continuum and the normal ageing (Teipel et al, 2011 ; Bosch et al, 2012 ; Tu et al, 2017 ). Due to the fact that DTI parameter changes might precede gray matter atrophy (Ibrahim et al, 2009 ; Selnes et al, 2012 ) and have significant correlation with cognitive performances (Grambaite et al, 2010 ), its application has been proven useful in predicting dementia conversion among MCI subjects (Haller et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Visual Attention Performances and Related Cerebral Microstructural Integrity Among Subjects With Subjective Cognitive Decline and Mild Cognitive Impairment

Huang

et al. 2018

Front. Aging Neurosci.

Self Cite

View full text Add to dashboard Cite

Objective: To compare visual attention performances and diffusion tensor imaging (DTI) between subjects with subjective cognitive decline (SCD) and mild cognitive impairment (MCI), and to discover neuronal substrates related to visual attention performances.Methods: Thirty-nine subjects with SCD and 15 with MCI, diagnosed following neuropsychological tests and conventional brain magnetic resonance imaging, were recruited. All subjects were further examined by the Conners Continuous Performance Test 3 (CPT3) and DTI including fractional anisotropy (FA) and mean diffusivity (MD), in which group comparisons and stepwise linear regression were made.Results: Subjects with MCI had a worse performance in all retrieval indices of verbal/nonverbal memory tests than those with SCD in the context of comparable general cognition and demographic status. In the CPT3, subjects with MCI had a significant longer hit reaction time (HRT) by univariate but not multivariate comparisons. Further analysis suggested that a longer HRT across all interstimuli intervals and at the point of fourth to sixth blocks were noted among MCI subjects. In DTI evaluations, FA value within the left forceps major was the only hotspot with significant between-group differences after the Bonferroni correction of FA and MD values. On the basis that HRT had significant inverse correlations with FA value within the genu of the corpus callosum and left forceps minor, regression analysis was conducted, showing HRT was best predicted by the FA value within the left forceps minor. Area under receiver operative characteristic curve was 0.70; the optimum cut-off for HRT was 515.8 ms, with a sensitivity of 85% but specificity of 47%.Conclusions: Our report suggested that impaired sustained attention and vigilance to be an early cognitive marker in differentiating MCI from SCD, where MCI subjects had a longer HRT across all interstimuli intervals and more profoundly in later blocks. FA measures appeared to be more sensitive DTI parameters than MD values in detecting microstructural changes between SCD and MCI. The role of the anterior interhemispheric fibers in sustained attention implementation during visual signal detection task was highlighted.

show abstract

“…In other words, the assessment of WMHs may have a ceiling effect and therefore attenuate its impact on functional status performance among patients with SIVD. Another possible explanation is that patients with SIVD have a more profound fiber disconnection state than those with AD [68], raising the possibility that associations between PWMHs and executive function may vary according to the subtype of dementia. Incorporating other WMH scales specific for cholinergic pathways [69], or other novel sequences measuring cerebral microstructural [68] and blood flow changes [70] should be considered for future studies.…”

Section: Discussionmentioning

confidence: 99%

Comparisons of Daily Functional Performance and Relevant Factors in Patients with Alzheimer’s Disease and Subcortical Ischemic Vascular Disease

Tu¹,

Huang²,

Lo³

et al. 2018

Neuropsychiatry

Self Cite

View full text Add to dashboard Cite

ObjectiveTo compare daily functional performance and potential predictive factors in patients with Alzheimer's disease (AD) and subcortical ischemic vascular disease (SIVD). MethodsSixty-eight community patients with AD and 39 with SIVD were evaluated using the informantbased Barthel Index of Activities of Daily Living (B-ADL) and Instrumental Activities of Daily Living (IADL). Motor function, cognition, and white matter hyperintensities (WMHs) were assessed using the modified Rankin Scale (mRS), Cognitive Abilities Screening Instrument (CASI)/Clinical Dementia Rating (CDR), and Scheltens scale, respectively. ResultsAfter controlling for systemic diseases and medications, toilet use was the only B-ADL subset in which the patients with SIVD performed worse than those with AD in overall comparisons and CDR0.5-1. Additionally, the SIVD group with CDR0.5-1 performed worse in bathing, mobility, and climbing stairs. Regarding IADL performance, the SIVD group had worse performances than the AD group in mode of transportation during CDR2. In WMHs analysis, periventricular WMHs (PWMHs) was the only factor showing significant inverse correlations with both CASI and B-ADL/IADL. Hierarchical regression of all patients suggested that the best models including age, education, PWMHs, CASI, and mRS accounted for 71% and 78% of the variances in B-ADL and IADL, respectively. While mRS accounted for a significant effect in both B-ADL and IADL, CASI accounted for a significant effect only in IADL. Subgroup analysis suggested that the effects of CASI and PWMHs were confined within B-ADL/IADL and IADL in the AD group, respectively. ConclusionsMotor function was the major factor in both B-ADL and IADL, and cognition had a significant effect on IADL. Although PWMH load had inverse associations with both motor and cognitive functions, this radiological marker better predicted IADL in AD than in SIVD. The variation in daily functional profiles with dementia stage and subtypes highlights the need to assess motor function for preventive interventions. Keywords Subcortical ischemic vascular disease; Alzheimer's disease; Cognition; Motor function; Activities of daily life; Instrumental activities of daily life; White matter hyperintensities Neuropsychiatry (London) (2018) 8(2) 558Research Yen-Hsuan Hsu care strategy [14].Several studies have reported ADL profiles and their relevant impact among patients with AD [15][16][17]. However, the functional profiles and determining factors in individuals with SIVD have yet to be fully elucidated [18][19][20], and comparisons of these two prevalent subtypes of dementia are even more limited [19][20]. Therefore, the aims of the current study were to compare the profiles of ADL performance between patients with SIVD and AD subtypes, and to analyze predictors of daily functional performance in different subtypes of dementia by examining the associations between clinical factors, cognitive/motor function, and WMHs. Materials and MethodsSixty-eight community patients with AD and 39 with SIVD who visited the...

show abstract

Effectiveness of diffusion tensor imaging in differentiating early-stage subcortical ischemic vascular disease, Alzheimer’s disease and normal ageing

Cited by 41 publications

References 49 publications

Age‐dependent amyloid deposition is associated with white matter alterations in cognitively normal adults during the adult life span

Age‐dependent amyloid deposition is associated with white matter alterations in cognitively normal adults during the adult life span

Visual Attention Performances and Related Cerebral Microstructural Integrity Among Subjects With Subjective Cognitive Decline and Mild Cognitive Impairment

Comparisons of Daily Functional Performance and Relevant Factors in Patients with Alzheimer’s Disease and Subcortical Ischemic Vascular Disease

Contact Info

Product

Resources

About