Effectiveness of different treatments in obesity hypoventilation syndrome

Molina, Victor R. Ramírez; Jiménez, J.F. Masa; Terreros, F.J. Gómez de; Peñafiel, Jaime

doi:10.1016/j.pulmoe.2020.05.012

Cited by 6 publications

(10 citation statements)

References 69 publications

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“…When compared to conventional treatment, BMS results in more substantial and durable weight loss while improving inflammatory markers, insulin sensitivity (HOMA-IR) and resolving other underlying disease processes, including metabolic syndrome, T2DM, glycosylated haemoglobin (HbA1c), NASH, aromatase activity, visceral obesity, hypoxia and OSA [ 23 , 31 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 ]. RYGB surgery has been shown to decrease macrophage infiltration and crown-like structures (CLS) in subcutaneous adipose tissue (SAT), indicating improvement in local white adipose tissue (WAT) inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…For example, both LSG and RYGB are associated with rapid and sustained decrease in fasting serum leptin levels (males: 31.3 ± 10.5 vs. 6.1 ± 5.5 ng/mL, p < 0.001; females: 60.2 ± 14.3 vs. 12.5 ± 9.4 ng/mL, p < 0.001) and doubling in fasting serum adiponectin levels (males: 3.4 ± 1.6 vs. 8.9 ± 4.8 ng/mL; females 6.1 ± 1.8 vs. 11.6 ± 3.7 ng/mL, p < 0.001), respectively, comparing preoperative and postoperative levels 12 months after surgery. The greatest improvements in adipokines after BMS occur in patients with higher preoperative BMI and metabolic syndrome [ 23 , 31 , 97 , 99 , 100 ]. The decrease in leptin, cytokines, PGE2 and NF-κB activation and the resultant lowering of WAT aromatase activity after bariatric surgery are associated with larger postoperative falls in the serum oestradiol at 12 months after surgery in older women (53.9 to 35.7 pg/mL) as compared to oestradiol in younger women (94.85 to 73.62 pg/mL).…”

Section: Discussionmentioning

confidence: 99%

“…Conventional obesity management usually consists of dietary modification, caloric restriction, weight reduction and exercise. However, such lifestyle measures result in only modest weight loss, ranging, at most, 5–10% of an individual’s total body weight (TBW) [ 23 , 24 ]. Lifestyle interventions have poor sustainability due to an established hypothalamic ‘set point’ and compensatory neurohormonal responses to attempted caloric restriction during dieting and increased energy expenditure during exercise.…”

Section: Introductionmentioning

confidence: 99%

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Systematic Review and Meta-Analysis of the Impact of Bariatric Surgery on Future Cancer Risk

Wilson

Lathigara

Kaushal

2023

IJMS

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The study aimed to perform a systematic review and meta-analysis of the evidence for the prevention of future cancers following bariatric surgery. A systematic literature search of the Cochrane Library, Embase, Scopus, Web of Science and PubMed databases (2007–2023), Google Scholar and grey literature was conducted. A meta-analysis was performed using the inverse variance method and random effects model. Thirty-two studies involving patients with obesity who received bariatric surgery and control patients who were managed with conventional treatment were included. The meta-analysis suggested bariatric surgery was associated with a reduced overall incidence of cancer (RR 0.62, 95% CI 0.46–0.84, p < 0.002), obesity-related cancer (RR 0.59, 95% CI 0.39–0.90, p = 0.01) and cancer-associated mortality (RR 0.51, 95% CI 0.42–0.62, p < 0.00001). In specific cancers, bariatric surgery was associated with reduction in the future incidence of hepatocellular carcinoma (RR 0.35, 95% CI 0.22–0.55, p < 0.00001), colorectal cancer (RR 0.63, CI 0.50–0.81, p = 0.0002), pancreatic cancer (RR 0.52, 95% CI 0.29–0.93, p = 0.03) and gallbladder cancer (RR 0.41, 95% CI 0.18–0.96, p = 0.04), as well as female specific cancers, including breast cancer (RR 0.56, 95% CI 0.44–0.71, p < 0.00001), endometrial cancer (RR 0.38, 95% CI 0.26–0.55, p < 0.00001) and ovarian cancer (RR 0.45, 95% CI 0.31–0.64, p < 0.0001). There was no significant reduction in the incidence of oesophageal, gastric, thyroid, kidney, prostate cancer or multiple myeloma after bariatric surgery as compared to patients with morbid obesity who did not have bariatric surgery. Obesity-associated carcinogenesis is closely related to metabolic syndrome; visceral adipose dysfunction; aromatase activity and detrimental cytokine, adipokine and exosomal miRNA release. Bariatric surgery results in long-term weight loss in morbidly obese patients and improves metabolic syndrome. Bariatric surgery may decrease future overall cancer incidence and mortality, including the incidence of seven obesity-related cancers.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Systematic Review and Meta-Analysis of the Impact of Bariatric Surgery on Future Cancer Risk

Wilson

Lathigara

Kaushal

2023

IJMS

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“… Inflammation and metabolism: CLS, cytokines and glycolysis. Hypoxia: HIF-1α, CLS, EMT, angiogenesis, VAT and OSA [ 50 ]. WAT and Hepatocyte Extracellular matrix: CLS, NASH, fibrosis and cirrhosis [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

“…Obese individuals often have comorbid obesity hypoventilation syndrome (OHS), which is characterised by daytime hypercapnia, intermittent nocturnal hypoxia and sleep-disordered breathing including severe or moderate OSA [ 50 ]. Up to 90% of OHS patients will have OSA, and 73% have severe OSA.…”

Section: Hypoxiamentioning

confidence: 99%

Molecular Mechanisms of Western Diet-Induced Obesity and Obesity-Related Carcinogenesis—A Narrative Review

2023

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The present study aims to provide a narrative review of the molecular mechanisms of Western diet-induced obesity and obesity-related carcinogenesis. A literature search of the Cochrane Library, Embase and Pubmed databases, Google Scholar and the grey literature was conducted. Most of the molecular mechanisms that induce obesity are also involved in the twelve Hallmarks of Cancer, with the fundamental process being the consumption of a highly processed, energy-dense diet and the deposition of fat in white adipose tissue and the liver. The generation of crown-like structures, with macrophages surrounding senescent or necrotic adipocytes or hepatocytes, leads to a perpetual state of chronic inflammation, oxidative stress, hyperinsulinaemia, aromatase activity, activation of oncogenic pathways and loss of normal homeostasis. Metabolic reprogramming, epithelial mesenchymal transition, HIF-1α signalling, angiogenesis and loss of normal host immune-surveillance are particularly important. Obesity-associated carcinogenesis is closely related to metabolic syndrome, hypoxia, visceral adipose tissue dysfunction, oestrogen synthesis and detrimental cytokine, adipokine and exosomal miRNA release. This is particularly important in the pathogenesis of oestrogen-sensitive cancers, including breast, endometrial, ovarian and thyroid cancer, but also ‘non-hormonal’ obesity-associated cancers such as cardio-oesophageal, colorectal, renal, pancreatic, gallbladder and hepatocellular adenocarcinoma. Effective weight loss interventions may improve the future incidence of overall and obesity-associated cancer.

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Obesity Hypoventilation Syndrome

Mohammadi,

Rezaei

2024

Genetic Syndromes

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Effectiveness of different treatments in obesity hypoventilation syndrome

Cited by 6 publications

References 69 publications

Systematic Review and Meta-Analysis of the Impact of Bariatric Surgery on Future Cancer Risk

Systematic Review and Meta-Analysis of the Impact of Bariatric Surgery on Future Cancer Risk

Molecular Mechanisms of Western Diet-Induced Obesity and Obesity-Related Carcinogenesis—A Narrative Review

Obesity Hypoventilation Syndrome

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