Effectiveness of different treatment regimens in helicobacter pylori eradication: Ten-year experience of a single institution

Özden, Ali; Seven, Gülseren; Bektaş, Mehmet

doi:10.4318/tjg.2010.0091

Cited by 9 publications

(6 citation statements)

References 33 publications

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“…The result of our study is consistent with the results reported in developing countries. There are also similar results from our country which reported that eradication rates were under 80% (13)(14)(15)(16)(17). Pathogenesis of H. pylori infection depends on the virulence factor of the bacteria and host immune system.…”

supporting

confidence: 75%

The Efficacy of Quadruple Therapy in Eradication of Helicobacter pylori in Cases of Duodenal Ulcer

Kefeli¹,

Başyiğit²,

Yeniova³

et al. 2016

West Indian Med J

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Background: Helicobacter pylori (H. pylori) is an important cause of duodenal ulcer (DU) and eradication this infection can prevent complication related to DU and recurrence of the DU.Quadruple therapy (QT) is one of the recommended treatment regimen for the H. pylori eradication. But there has not been enough data for impact of the QT on eradication success of the H. pylori in patients with DU. We aimed to investigate success of QT in H. pylori positive patients with DU. Method:We included 140 patients who had DU and histology proven H. pylori infection into the study. All patients were given a quadruple therapy program for 14 days consisting of colloidal bismuth substrate 300 mg 2x2; tetracycline hydrochloride 500 mg (qid); metronidazole 500 mg (tid) and a proton pump inhibitor (PPI) (bid) randomly which esomeprazole 20 mg for patients in group 1 (ETMB), lansoprasol 30 mg for group 2 (LTMB), pantoprazole 40 mg for group 3 (PTMB) and rabeprazole 20 mg for group 4 (RTMB). Eradication rate was measured by urea breath test at least 6 weeks after the end of the treatment Results: Average eradication rate was 78.8 % in ITT analysis (%95 CI 0. 71-0. 84) and 81.8% in PP analysis for all groups (% 95 CI 0. 74-0. 87). There was no significant differences between different PPI groups. Conclusion:In patients with DU and H. pylori infection, QT can provide an acceptable but not enough successful eradication success.

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supporting

confidence: 75%

The Efficacy of Quadruple Therapy in Eradication of Helicobacter pylori in Cases of Duodenal Ulcer

Kefeli¹,

Başyiğit²,

Yeniova³

et al. 2016

West Indian Med J

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“…Few reports in literature on standard triple therapy with bismuth salts in Turkey have shown variable eradication rates (57.6-90.7%) [3,37,38]. In our previous study, we compared H. pylori eradication rates of clarithromycin-based triple therapy and BCQT and observed 50% and 92% eradication, respectively [39].…”

Section: Discussionmentioning

confidence: 88%

Different bismuth-based therapies for eradicating Helicobacter pylori: Randomized clinical trial of efficacy and safety

Gökcan¹,

Öztaş²,

Önal³

2016

Clinics and Research in Hepatology and Gastroenterology

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“…Ankara Üniversitesi'nin son 10 yıllık verilerine göre klasik üçlü tedavi ile Hp eradikasyon başarı oranı %74,7 bulunmuş olup bizim sonuçlarımızla benzerlik göstermektedir. 15 Hp, artan antibiyotik direnci nedeniyle giderek eradikasyonu çok zor bir bakteri haline gelmektedir. Kullanılan tedavi şemalarının her geçen gün kan kaybetmesi bizmut tuzlarının bu şemalara eklenerek eradikasyon başarısının artırılabileceği düşüncesini akla getirmektedir.…”

Section: Discussionunclassified

Effect of bismuth addition to the triple therapy of Helicobacter pylori eradication

Çekın¹

2012

Dicle Med J

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Objective: Success rates of amoxicillin, clarithromycin, and proton-pump inhibitor therapy in the Helicobacter pylori (Hp) eradication have been decreasing. The aim of this study was to investigate the impact of bismuth subcitrate addition to triple therapy. Materials and methods: 148 patients diagnosed Hp infection with both histology and Hp stool antigen (HpSA) tests were examined retrospectively. The patients were divided into 3 groups according to the eradication therapy. The first group received triple therapy with claritromycine 2x 500 mg, amoxicilline 2x1 g and PPI 2x1 for 14 days (n=40). The second group had bismuth subcitrate 4x120 mg with triple therapy for 14 days (n=73). The third group received 14 days pretreatment with bismuth subcitrate 4x1 together with PPI 2x1 then had triple therapy for 14 days (n=35). (14)C urea breath and HpSA tests were used to detect posttreatment H.pylori status. Results: There were no statistical difference between the groups in terms of gender and age (p > 0.05). In group one 12 patients, in group two 20 patients and in group three 10 patients were identified as Hp positive after treatment. Eradication rates were 70% for group one, 72.6% for group two and 71.4% for group three respectively. There was no statistical difference between the groups in terms of eradication rates of treatment (p > 0.05). Conclusions: The addition of bismuth to conventional triple therapy did not affect treatment success rates.

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Effectiveness of different treatment regimens in helicobacter pylori eradication: Ten-year experience of a single institution

Cited by 9 publications

References 33 publications

The Efficacy of Quadruple Therapy in Eradication of Helicobacter pylori in Cases of Duodenal Ulcer

The Efficacy of Quadruple Therapy in Eradication of Helicobacter pylori in Cases of Duodenal Ulcer

Different bismuth-based therapies for eradicating Helicobacter pylori: Randomized clinical trial of efficacy and safety

Effect of bismuth addition to the triple therapy of Helicobacter pylori eradication

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