Effectiveness of dexmedetomidine in reducing bleeding during septoplasty and tympanoplasty operations

Ayoğlu, Hilal; Yapakçi, Osman; Uğur, Mehmet Birol; Uzun, Lokman; Altunkaya, Hanife; Özer, Yetkin; Uyanik, Rahsan; Çınar, Fikret; Özkoçak, Işıl

doi:10.1016/j.jclinane.2008.04.008

Cited by 80 publications

(63 citation statements)

References 26 publications

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“…This result was similar to those reported by Durmus et al 16 , Ayoglu et al 17 , and Hall et al 30 In another report, MAP was decreased only by approximately 15% even during relatively high dose infusion of 2 μg･kg -1 DEX. 31 Thus, it is suggested that DEX-induced hypotension does not make a major contribution to the decreases in oral tissue blood flow.…”

Section: Discussionsupporting

confidence: 92%

“…29 Richa et al 18 reported that bleeding during maxillofacial surgery was decreased by an initial loading dose of 0.1 μg･kg -1 ･min -1 followed by a continuous infusion at 0.4-0.7 μg･kg -1 ･hr -1 , and they considered that this decrease was attributable to stable hypotensive condition (approximately 30% reduction in MAP). Meanwhile, during tympanoplasty and septorhinoplasty, Durmus et al 16 used an initial loading dose of 1 μg･kg -1 ･hr -1 followed by 0.5 μg･kg -1 ･hr -1 , and Ayoglu et al 17 used an initial loading dose of 1 μg･ kg -1 ･ hr -1 followed by 0.7 μg ･ kg -1 ･ hr -1 . Although bleeding during surgery was decreased in these reports, MAP was decreased only by approximately 10% of the 13 control value.…”

Section: Discussionmentioning

confidence: 99%

“…12 Recent studies report an infusion of dexmedetomidine (DEX), a highly selective α2 agonist, [13][14][15] decreased bleeding during surgery. [16][17][18] Durmus et al 16 and Ayoglu et al 17 reported that DEX decreased bleeding during tympanoplasty and septorhinoplasty. Richa et al 18 reported that DEX decreased bleeding during maxillofacial surgery.…”

Section: Introductionmentioning

confidence: 99%

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Dexmedetomidine Dose Dependently Decreases Oral Tissue Blood Flow During Sevoflurane and Propofol Anesthesia in Rabbits

Sazuka

Matsuura

Ichinohe

2012

Journal of Oral and Maxillofacial Surgery

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Purpose: The aim of this study was to investigate the effect of dexmedetomidine (DEX) continuous infusion on blood flow in rabbit oral tissues during sevoflurane or propofol anesthesia.Methods: Twenty-four male tracheotomized Japan White rabbits were anesthetized with sevoflurane or propofol under mechanical ventilation. An initial loading dose of 6.0 μg･kg -1 ･hr -1 DEX was administered over 10 minutes. DEX was then maintained at

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dexmedetomidine Dose Dependently Decreases Oral Tissue Blood Flow During Sevoflurane and Propofol Anesthesia in Rabbits

Sazuka

Matsuura

Ichinohe

2012

Journal of Oral and Maxillofacial Surgery

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“…In our study, none of the patients suffered from respiratory depression as we did not use dexmedetomidine in high doses. However, Hilal et al, 21 provided contrasting findings on effects Of intraoperative surgical bleeding during tympanoplasty and septoplasty. They noted that dexmedetomidine played a significant role in reducing both intraoperative bleeding and fentanyl dosage requirement in septoplasty whereas in tympanoplasty, attenuation in intraoperative bleeding was not found to be significant.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of dexmedetomidine infusion as an anesthetic adjuvant to provide oligemic surgical field in middle ear surgeries

M¹

2017

JMSCR

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“…The preferred technique is a combination of remifentanil with propofol or an inhalation agent (isoflurane, desflurane, or sevoflurane) (7)(8)(9)(10)(11). Alpha-2 adrenergic agonists (clonidine and dexmedetomidine) have been used successfully as adjuvants, oral premedication, and intravenous infusion during anesthesia to induce controlled hypotension (12)(13)(14)(15)(16)(17)(18)(19)(20). Clonidine is an alpha-2 adrenergic agonist, which has been used as a centrally acting antihypertensive drug.…”

Section: Discussionmentioning

confidence: 99%

Effect of Clonidine Premedication on Blood Loss in Spine Surgery

et al. 2012

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The addition of oral clonidine to anesthetic management of spine surgery offers clinical advantages. Further dose-finding studies in more complicated spine surgeries are warranted. BackgroundSpinal fusion surgery is often associated with major blood loss, which is sometimes significant, requiring the transfusion of blood or blood products (1). Blood loss can be an acute problem not only in major deformity surgery but also in less extensive fusion procedures. DecreasingBackground: Blood loss in spine surgery is an important issue, even though it has been understudied compared with hip and knee arthroplasty. Objectives: In this study, we evaluated the effect of oral clonidine as premedication on blood loss in lumbar spine fusion surgery under anesthesia with propofol and remifentanil. Patients and Methods:In this double-blind, randomized clinical trial, 30 patients who were undergoing lumbar spine posterior fusion surgery due to traumatic fracture were allocated randomly into 2 groups. The study group (clonidine group) received a 200-µg oral clonidine tablet 60-90 minutes before anesthesia, and the control group received placebo at the same time. Induction and maintenance of anesthesia and the mean target arterial pressure for controlled hypotension with remifentanil were the same in the 2 groups. We compared the amount of intraoperative blood loss, dose of remifentanil/ hour administered, need for nitroglycerine to reach the mean target arterial pressure when remifentanil was insufficient, duration of operation, and surgeon's satisfaction of a bloodless field between groups. Results: There was no statistically significant difference between groups in age (P = 0.115), sex (P = 0.439), weight (P = 0.899), operation time (P = 0.2), or American Society of Anesthesiologists physical status score (P = 0.390). Intraoperative blood loss and remifentanil dose administered per hour in the clonidine group were significantly less than in the control group (P = 0.002 and P = 0.001, respectively), but there was no significant difference in surgeon's satisfaction between groups (P = 0.169). Conclusions: As an oral premedication, clonidine can reduce surgical blood loss in lumbar spine posterior fusion surgery, even at the same levels of mean arterial pressure (MAP) with the control group. Its use can be studied in more complicated spine surgeries, such as scoliosis and spinal deformity surgeries.

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Effectiveness of dexmedetomidine in reducing bleeding during septoplasty and tympanoplasty operations

Cited by 80 publications

References 26 publications

Dexmedetomidine Dose Dependently Decreases Oral Tissue Blood Flow During Sevoflurane and Propofol Anesthesia in Rabbits

Dexmedetomidine Dose Dependently Decreases Oral Tissue Blood Flow During Sevoflurane and Propofol Anesthesia in Rabbits

Efficacy of dexmedetomidine infusion as an anesthetic adjuvant to provide oligemic surgical field in middle ear surgeries

Effect of Clonidine Premedication on Blood Loss in Spine Surgery

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