Effectiveness of current disinfection procedures against biofilm on contaminated GI endoscopes

Neves, Marcelo Soares; Silva, Marlei Gomes da; Ventura, G.; Côrtes, Patrícia Barbur; Duarte, Rafael Silva; Souza, Heitor Siffert Pereira de

doi:10.1016/j.gie.2015.09.016

Cited by 46 publications

(28 citation statements)

References 49 publications

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“…Bacterial biofilms play an important role in different medical settings, and they represent a potential source of infection, especially on medical devices (Fang et al 2010;Ren et al 2013;Kampf et al 2014;Ren-Pei et al 2014;Neves et al 2015).…”

Section: Discussionmentioning

confidence: 99%

“…; Neves et al . ). Biofilms containing living bacteria were also discovered on clinical surfaces in the vicinity of patients (Vickery et al .…”

Section: Introductionmentioning

confidence: 97%

“…2004). Bacterial biofilm contaminations have also been detected on medical instruments such as probes and endoscopes, causing problems in the reprocessing of these devices (Fang et al 2010;Ren et al 2013;de Souza et al 2014;Neves et al 2015). Biofilms containing living bacteria were also discovered on clinical surfaces in the vicinity of patients (Vickery et al 2012;Hu et al 2015).…”

mentioning

confidence: 99%

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Comparative testing of disinfectant efficacy on planktonic bacteria and bacterial biofilms using a new assay based on kinetic analysis of metabolic activity

et al. 2016

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Although bacterial biofilms are the predominant manner of bacterial colonization, most standard procedures for antimicrobial susceptibility testing and efficacy testing of disinfectants are adapted for application to planktonic bacteria. To our knowledge, this is the first study to use a newly developed microplate-based biofilm test system that uses kinetic analysis of the metabolic activity in biofilms, after disinfectant exposure, to evaluate disinfectant efficacy. Our study shows that findings obtained from disinfectant efficacy testing on planktonic bacteria cannot be extrapolated to predict disinfectant efficacy on bacterial biofilms of clinically relevant multidrug-resistant organisms.

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Section: Discussionmentioning

confidence: 99%

“…; Neves et al . ). Biofilms containing living bacteria were also discovered on clinical surfaces in the vicinity of patients (Vickery et al .…”

Section: Introductionmentioning

confidence: 97%

mentioning

confidence: 99%

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Comparative testing of disinfectant efficacy on planktonic bacteria and bacterial biofilms using a new assay based on kinetic analysis of metabolic activity

et al. 2016

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“…If reprocessing is performed promptly after use and the endoscope is dry, the opportunity for biofilm formation is minimal. 45,46 However, the formation of endoscopic biofilm during clinical practice may be related to reuse of reprocessing methods, such as reuse of detergent, manual cleaning, and incomplete drying. 47 Ideally, reprocessing should be initiated within an hour of use; however, there are no evidence-based guidelines on delayed endoscope reprocessing.…”

Section: Outbreaks Of Carbapenem-resistant Enterobacteriaceae Infectimentioning

confidence: 99%

Disinfection and Sterilization in Health Care Facilities

Rutala

Weber

2016

Infectious Disease Clinics of North America

150

104

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“…In addition to meticulous channel flushing and cleaning, it is increasingly appreciated that adequate instrument and, in particular, channel drying is essential in preventing its formation. Viable microorganisms in endoscope channel biofilm can survive reprocessing . A “buildup biofilm” model was developed, which mimics the cumulative effect of reprocessing protocols on flexible endoscopes .…”

Section: Methodsmentioning

confidence: 99%

Australian infection control in endoscopy consensus statements on carbapenemase‐producing Enterobacteriaceae

Devereaux

Athan

Brown³

et al. 2018

J of Gastro and Hepatol

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Outbreaks of carbapenemase‐producing Enterobacteriaceae clinical infections related to endoscopic transmission are well documented. The high morbidity and mortality associated with these infections emphasizes the need to reassess endoscopic reprocessing protocols. The Gastroenterological Society of Australia established a multi‐society committee to formulate evidence‐based consensus statements on the prevention and management of endoscopic transmission of carbapenemase‐producing Enterobacteriaceae. A literature search was undertaken utilizing the MEDLINE database. Further references were sourced from published paper bibliographies. Nine statements were formulated. Using the Delphi methodology, the statements were initially reviewed electronically by the committee members and subsequently at a face‐to‐face meeting in Melbourne, Australia. After further discussion, four additional sub‐statements were added resulting in a total of 13 statements. Each statement was assessed for level of evidence, recommendation grade and the voting on recommendation was recorded. For a statement to be accepted, five out of six committee members had to “accept completely” or “accept with some reservation.” All 13 statements achieved consensus agreement. Eleven statements achieved 100% “accepted completely.” Two statements were 83% “accepted completely” and 17% “accepted with some reservation.” Of particular significance, automated flexible endoscope reprocessors were mandated for high‐level disinfection, and the use of forced‐air drying cabinets was mandated for endoscope storage. These evidence‐based statements encourage preventative strategies with the aim of ensuring the highest possible standards in flexible endoscope reprocessing thereby optimizing patient safety. They must be considered in addition to the broader published guidelines on infection control in endoscopy.

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Effectiveness of current disinfection procedures against biofilm on contaminated GI endoscopes

Cited by 46 publications

References 49 publications

Comparative testing of disinfectant efficacy on planktonic bacteria and bacterial biofilms using a new assay based on kinetic analysis of metabolic activity

Comparative testing of disinfectant efficacy on planktonic bacteria and bacterial biofilms using a new assay based on kinetic analysis of metabolic activity

Disinfection and Sterilization in Health Care Facilities

Australian infection control in endoscopy consensus statements on carbapenemase‐producing Enterobacteriaceae

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