Effectiveness of cooling therapy (cryotherapy) on leg pain and self-efficacy in patients with chronic venous disease: A randomized controlled trial

Kelechi, Teresa J.; Mueller, Martina; Madisetti, Mohan; Prentice, Margaret; Dooley, Mary

doi:10.1016/j.ijnurstu.2018.04.015

Cited by 8 publications

(8 citation statements)

References 43 publications

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“…It is difficult to draw a solidified conclusion on chronic venous disease and MS due to lack of studies in the literature. The one study we found on chronic venous disease, conducted by Kelechi et al, reported a reduction in both long-term (measured by Venous Insufficiency Epidemiological and Economic Study-Quality of Life/Symptoms, VEINES-QOL/Sym) and short-term pain (measured by the Numeric Rating Scale, NRS) in the group that received cryocuff therapy as well as the placebo group that received a cotton-filled cuff, with no significant differences between groups [44]. Since there were no differences between groups, it could be plausible that the compression from the cryocuff had an impact on pain rather than the cold therapy itself.…”

Section: Othermentioning

confidence: 72%

Use of Cryotherapy for Managing Chronic Pain: An Evidence-Based Narrative

et al. 2020

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Section: Othermentioning

confidence: 72%

Use of Cryotherapy for Managing Chronic Pain: An Evidence-Based Narrative

et al. 2020

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“…No statistically significant differences in scores at baseline, nor differences in change from baseline to the end of study were observed between groups; however, both groups experienced statistically significant decreases in mean pain scores (Δ =−1.5, P <.001; Δ =−1.7, P <.001 respectively). (20)…”

Section: Discussionmentioning

confidence: 99%

Symptoms Associated With Chronic Venous Disease in Response to a Cooling Treatment Compared to Placebo

Kelechi

Dooley

Mueller

et al. 2018

Journal of Wound, Ostomy &Amp; Continence Nursing

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Of the 11 symptoms, aching, throbbing, itching, and pain had greater clinically meaningful improvements in response to a cooling cuff applied to lower leg skin affected by chronic venous disease. These CMDs inform evidence-based practice by enhancing clinician understanding of which symptoms, physical, physiological, and behavioral outcomes, respond to treatment change in a meaningful way for the patient.

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“…It is a widely held belief that the sensory neuropathy that often accompanies foot ulcers leads to an “insensate” foot; paradoxically, pain is present in up to 75% of individuals with diabetes-related foot ulcers 12. Pain and other uncomfortable symptoms such as itch, tingling, and achiness are also prevalent in patients with healed ulcers 13. Research also shows a high number of individuals with VLUs and DFUs are physically deconditioned, less physically active, have poor balance and gait abnormalities, and are slower walkers 14,15.…”

Section: Introductionmentioning

confidence: 99%

“…23,24 There are also benefits in reducing pain through affecting nociceptor function and slowing nerve transmission velocity in pain fibers. 13,25 Pain, in particular, is known to negatively influence physical activity in patients with chronic venous disease. 26 In an attempt to address pain and physical activity, we developed a topically applied cooling patch as part of our MUSTCOOL intervention and posited that if pain was reduced, individuals would feel better and become more physically active.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of a Self-managed Cooling Intervention for Pain and Physical Activity in Individuals With Recently Healed Chronic Venous Leg and Diabetic Foot Ulcers

Kelechi

Mueller

Madisetti

et al. 2022

Journal of Wound, Ostomy &Amp; Continence Nursing

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PURPOSE: This aim of this study was to evaluate the clinical efficacy of a self-managed cooling intervention in individuals with recently healed venous leg ulcers (VLUs) and diabetic foot ulcers (DFUs) on pain reduction and physical activity improvement. DESIGN: A 6-month longitudinal randomized controlled trial. SUBJECTS AND SETTING: The sample comprised 140 individuals with previously healed VLU and DFU who received care in 3 outpatient wound centers in the Southeastern region of the United States. Participants were randomized to the MUSTCOOL or a placebo cooling patch intervention. METHODS: The cooling and placebo interventions comprised cooling or cotton-filled patch application to recently healed skin for 30 minutes, 3 times weekly plus standard of care including compression and leg elevation (participants with VLU) or therapeutic footwear and hygiene (participants with DFU) over a 6-month period. Pain severity and intensity were measured with the Brief Pain Inventory and physical activity with the International Physical Activity Questionnaire, which assessed metabolic equivalent of tasks (METs) in minutes per week. Minutes in walking time per week were assessed with an accelerometer. Data were descriptively analyzed for difference changes in scores from baseline to 6 months post-intervention. RESULTS: Data were analyzed for 81 participants randomized to cooling and placebo groups (VLUs, n = 26/29) and DFU (n = 12/16). Slight reductions in VLU pain severity (−0.5, −0.2) and interference (−0.4, −0.5) and minimal reductions in DFU pain severity (0, −0.1) and interference (0.4/0.1) were achieved. However, pain scores were low to moderate at baseline (mean 4, 0-10 with 10 worst pain possible) in both groups. For physical activity, the MET values showed low physical activity in both groups at baseline with slight improvements noted in VLU cooling and placebo groups (73/799) and DFU (1921/225), respectively. Walking time for the VLU groups improved by 1420/2523 minutes; the DFU groups improved 135/157 minutes, respectively. Findings for outcomes were not statistically significant within or between groups. CONCLUSIONS: Application of the cooling pack compared to placebo was minimally efficacious in reducing posthealing pain and improving function in this posthealed ulcer population. However for pain, scores were initially low; thus outcomes on pain, while lower, were marginal. TRIAL REGISTRATION: The study was prospectively registered with ClinicalTrials.gov on December 10, 2015 (Identifier: NCT02626156), https://clinicaltrials.gov/ct2/show/NCT02626156.

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Effectiveness of cooling therapy (cryotherapy) on leg pain and self-efficacy in patients with chronic venous disease: A randomized controlled trial

Abstract: Pain was reduced in both groups while self-efficacy did not change. Findings suggest that strictly implemented standard of CVeD care in each study group, with or without cooling, improved pain while there were no effects on self-efficacy.

Cited by 8 publications

References 43 publications

Use of Cryotherapy for Managing Chronic Pain: An Evidence-Based Narrative

Use of Cryotherapy for Managing Chronic Pain: An Evidence-Based Narrative

Symptoms Associated With Chronic Venous Disease in Response to a Cooling Treatment Compared to Placebo

Efficacy of a Self-managed Cooling Intervention for Pain and Physical Activity in Individuals With Recently Healed Chronic Venous Leg and Diabetic Foot Ulcers

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