Objectives: To compare the clinical outcomes of advanced platelet-rich fibrin with connective tissue graft in management of gingival recessionMaterials & Methods: 15 patients with isolated bilateral gingival recession were selected (n= 30 defects). These defects were miller’s class I/II gingival recession on canine or premolar region. They were divided into two equal groups (n=15), these groups were left and right sides in the patient’s mouth (split-mouth), in which each patient was treated with two techniques as follows; One side (Group I) was treated by coronally advanced flap with advanced platelet-rich fibrin (A-PRF). Whereas, the other side (Group II) was treated by coronally advanced flap with connective tissue graft (CTG). Clinical parameters such as recession height (RH), recession width (RW), probing pocket depth (PPD), clinical attachment level (CAL), width of attached gingiva (WAG), and keratinized tissue height (KTH) were evaluated at baseline, 3 & 6 months. Changes in biotype, Recession Esthetic Score (RES) & Visual Analogue Score-Esthetics (VAS-E) were evaluated at the end of 6 months.Trial registration: Ethics approval number (Helsinki): PHRC/HC/877/21 and registered at the Clinical Trials Registry under the number NCT05267015Results: At the end of 6 months, RH & RW showed significant reduction from baseline in both groups (p≤0.05). The mean RC% was 67.2%±32.8% and 86.6±35.18% in Group I, II respectively. Intergroup analysis showed statistically significant differences in recession parameters between both groups at 3 & 6 months (p≤0.05), with better outcomes for the second group.Conclusion: Both therapeutic interventions were effective in management of gingival recession defects. with significant improvement in recession parameters among group II compared to group I.Clinical Relevance: Miller’s class I&II can be improved by using A-PRF+CAF. However, CTG+CAF gives better results.