Effectiveness of Chinese Herbal Medicine Combined with Antibiotics for Extensively Drug-Resistant Enterobacteria and Nonfermentative Bacteria Infection: Real-Life Experience in a Retrospective Cohort

Cai, Yangping; Zhang, Qing; Fu, Yuefeng; Li, Li; Zhao, Ning; Lü, Aiping; Lian, Qingquan; Jiang, Miao

doi:10.1155/2017/2897045

Cited by 15 publications

(11 citation statements)

References 38 publications

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“… 16–18 A combination of phytochemicals with standard antibiotics has been shown to be very beneficial to fight drug-resistant pathogens. 19–22 The combination of menthol with nystatin and itraconazole showed a synergistic effect against the clinical isolates of Candida spp. 23 Moreover, the essential oil of Mentha suaveolens exhibited activity against the murine vaginal candidiasis.…”

Section: Introductionmentioning

confidence: 99%

Coadministration of Ginger Extract and Fluconazole Shows a Synergistic Effect in the Treatment of Drug-Resistant Vulvovaginal Candidiasis

Khan

Azam

Allemailem

et al. 2021

IDR

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Background Azoles are the most common antifungal drugs used in the treatment of vulvovaginal candidiasis (VVC). The frequency of azole-resistant Candida isolates has increased dramatically in the last two decades. Here, we assessed the antifungal activity of a combination of fluconazole (FLZ) and methanolic extract of ginger (Meth-Gin) against drug-resistant vulvovaginal candidiasis (VVC) in a murine model. Methods The in vitro activity of FLZ or a combination of FLZ and Meth-Gin was determined against Candida albicans by the agar well diffusion, macrodilution, time-kill and the biofilm eradication methods. The therapeutic efficacy of the formulations was assessed by analyzing the fungal load, pro-inflammatory cytokines, percent apoptotic cells and the histological changes in the vaginal tissues of the mice. Moreover, the renal toxicity the drug formulation was evaluated by analyzing the levels of the blood urea nitrogen (BUN) and creatinine. Results The results of in vitro study demonstrated that FLZ did not show any activity against C. albicans , whereas a combination of FLZ and Meth-Gin demonstrated greater activity as shown by the data of the zone of growth inhibition, MIC and time-kill assay. FLZ or Meth-Gin treatment could not completely cure VVC, whereas a combination of FLZ and Meth-Gin was greatly effective in the treatment of VVC. The vaginal tissue from mice of the infected control group had the highest fungal load of 155370 ± 20617 CFUs. Treatment with FLZ at a dose of 40 mg/kg reduced the fungal load to 120863 ± 10723 CFUs. Interestingly, the mice treated with a combination of FLZ (40 mg/kg) and Meth-Gin (200 mg/kg) had a fungal load of 256 ± 152 CFUs. Besides, FLZ and Meth-Gin combination effectively reduced the pro-inflammatory cytokines (IL-1β, TNF-α and IL-17) and the percentage of apoptotic cells in the vaginal tissues. Likewise, the histological analysis revealed the epithelial necrosis, shedding and ulceration in the vaginal tissue, whereas treatment with FLZ and Meth-Gin combination reversed the histopathological changes in the vaginal epithelium and lamina propria. Conclusion The findings of the current study suggest that the co-administration of Meth-Gin and FLZ may have a potential therapeutic effect in the treatment of azole-resistant candidiasis.

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Section: Introductionmentioning

confidence: 99%

Coadministration of Ginger Extract and Fluconazole Shows a Synergistic Effect in the Treatment of Drug-Resistant Vulvovaginal Candidiasis

Khan

Azam

Allemailem

et al. 2021

IDR

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“…Another intervention is controlling antimicrobials use, such as selecting novel antimicrobials with limited capacity to ARBs or using fewer antimicrobials. Moreover, traditional Chinese medicines (TCMs) were used in the treatment of infectious diseases to avoid antibiotic resistance ( Cai et al, 2017 ; Su et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Metagenomic Analysis of Antibiotic Resistance Genes in Untreated Wastewater From Three Different Hospitals

et al. 2021

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Controlling antibiotic resistance genes (ARGs) is a worldwide intervention to ensure global health. Hospital wastewater is the main pollution source of antibiotic-resistant bacteria and ARGs in the environment. Expanding our knowledge on the bacterial composition of hospital wastewater could help us to control infections in hospitals and decrease pathogen release into the environment. In this study, a high-throughput sequencing-based metagenomic approach was applied to investigate the community composition of bacteria and ARGs in untreated wastewater from three different types of hospitals [the general hospital, traditional Chinese medicine (TCM) hospital, and stomatology hospital]. In total, 130 phyla and 2,554 genera were identified from the microbiota of the wastewaters, with significantly different bacterial community compositions among the three hospitals. Total ARG analysis using the Antibiotic Resistance Genes Database (ARDB) and Comprehensive Antibiotic Resistance Database (CARD) revealed that the microbiota in the wastewaters from the three hospitals harbored different types and percentage of ARGs, and their composition was specific to the hospital type based on the correlation analysis between species and ARG abundance, some ARGs contributed to different bacterial genera with various relationships in different hospitals. In summary, our findings demonstrated a widespread occurrence of ARGs and ARG-harboring microbiota in untreated wastewaters of different hospitals, suggesting that protection measures should be applied to prevent human infections. Concurrently, hospital wastewater should be treated more specifically for the removal of pathogens before its discharge into the urban sewage system.

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“…In order to decrease the morbidity and mortality of infectious diseases, it is important to discover new drugs with effective antibacterial activities. Traditional herbal medicines were considered to possess effective antimicrobial activities and hard to acquire drug resistance [12]. Therefore, rPC, an anti-infective drug in traditional Chinese medicine, has the potential to become a novel therapy for bacterial infections.…”

Section: Discussionmentioning

confidence: 99%

Root tuber extract of <i>Polygooum cillinerve</i> (Nakai) Ohwi exerts antimicrobial and immunomodulatory activities

Cao¹,

Lv²,

Zhao³

et al. 2019

Trop. J. Pharm Res

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Purpose: To investigate the antibacterial and immunomodulatory activities of the root tuber extract of Polygonum ciliinerve (Nakai) ohwi, a traditional Chinese medicine. Methods: Minimum inhibitory concentrations (MICs) of root tuber extract of Polygonum ciliinerve (Nakai) ohwi (rPC) and the synergistic effects between rPC and antibiotics were evaluated by broth dilution. In vitro adhesion and invasion assays were used to determine the effect of rPC on bacterial adhesion and invasion. Furthermore, the immunomodulatory effects of rPC were assessed by western blot. Results: rPC treatment inhibited the growth of Staphylococcus aureus (MIC = 12 mg/ml) and Escherichia coli (MIC = 64 mg/mL). rPC also showed synergistic effects with penicillin (fractional inhibitory concentration, FIC = 0.45), vancomycin (FIC = 0.333), moxifloxacin (FIC = 0.25), and levofloxacin (FIC = 0.356). The adhesion and invasion of bacteria were also suppressed by rPC treatment. Moreover, rPC exhibited an immunomodulatory effect during bacterial infection. Conclusion: rPC shows antibacterial and immunomodulatory activites when assessed by multiple methods, and therefore is a potential therapeutic alternative agent for the treatment of bacterial infections.

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Effectiveness of Chinese Herbal Medicine Combined with Antibiotics for Extensively Drug-Resistant Enterobacteria and Nonfermentative Bacteria Infection: Real-Life Experience in a Retrospective Cohort

Cited by 15 publications

References 38 publications

Coadministration of Ginger Extract and Fluconazole Shows a Synergistic Effect in the Treatment of Drug-Resistant Vulvovaginal Candidiasis

Coadministration of Ginger Extract and Fluconazole Shows a Synergistic Effect in the Treatment of Drug-Resistant Vulvovaginal Candidiasis

Metagenomic Analysis of Antibiotic Resistance Genes in Untreated Wastewater From Three Different Hospitals

Root tuber extract of <i>Polygooum cillinerve</i> (Nakai) Ohwi exerts antimicrobial and immunomodulatory activities

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