Effectiveness of Calcium Phosphate Desensitising Agents in Dental Hypersensitivity Over 24 Weeks of Clinical Evaluation

Abstract

Background: Calcium phosphate-based compounds are used to treat dental hypersensitivity (DH). Their long-term clinical behaviour needs further research. This study compared the 24-week effectiveness of Teethmate Desensitizer (TD), a pure tetracalcium phosphate (TTCP) and dicalcium phosphate dihydrate (DCPD) powder/water, to that of Dentin Desensitizer (DD), and Bite & White ExSense (BWE), both of calcium phosphate crystallites. Methods: A total of 105 subjects were selected. A random table was utilised to form three groups of 35 subjects. DH was evaluated using the evaporative sensitivity, tactile sensitivity tests, and the visual analogue scale (VAS) of pain. Response was recorded before the application of the materials (Pre-1), immediately after (Post-0), at 1 week (Post-1), 4 weeks (Post-2), 12 weeks (Post-3) and 24 weeks (Post-4). The non-parametric distribution was assessed with the Shapiro–Wilk statistical test. Intra-group differences for the six time points were evaluated with the Friedman statistical test and the Kruskal–Wallis test. Results: All the materials decreased DH after 24 weeks in comparison to Pre-1. However, the TTCP/DCPD cement showed the greatest statistical efficiency. Conclusions: The significant decrease of VAS scores produced by TD in the long term suggest the material as the most reliable in the clinical relief of DH.

The Effectiveness of Calcium Phosphates in the Treatment of Dentinal Hypersensitivity: A Systematic Review

“…A total of 7515 articles were excluded after reading titles and/or abstracts, 12 records were excluded since reports were not retrieved, 57 records from database registers and 18 identified through other methods were read and analyzed in their full-text, and 55 records were excluded for reasons such as not good drugs tested ( n = 34), in vitro studies ( n = 11), or study on tooth decay ( n = 10), as shown in Figure 1 . Twenty records met the inclusion criteria and were included in the systematic review: Poliakova et al, 2022 [ 30 ], Alharith et al, 2021 [ 31 ], Amaechi et al, 2021 [ 32 ], Eyuboglu et al, 2020 [ 33 ], Usai et al, 2019 [ 34 ], Amaechi et al, 2018 [ 35 ], Ameen et al, 2018 [ 36 ], Anand et al, 2018 [ 37 ], Vano et al, 2017 [ 38 ], De Oliveira et al, 2016 [ 39 ], Wang et al, 2016 [ 40 ], Gopinath et al, 2015 [ 41 ], Jena et al, 2015 [ 42 ], Mehta et al, 2015 [ 43 ], Naoum et al, 2015 [ 44 ], Mehta et al, 2014 [ 45 ], Porciani et al, 2014 [ 46 ], Vano et al, 2014 [ 47 ], Ghassemi et al, 2009 [ 48 ], and Geiger et al, 2003 [ 49 ]. The selection process has been detailed in the attached PRISMA flowchart ( Figure 1 ).…”

“…The follow-up range varied from immediately to 6 months. Most of the studies performed a 4-week follow-up phase [ 30 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 47 , 48 , 49 ].…”

A Spectrophotometric Study on Light Attenuation Properties of Dental Bleaching Gels: Potential Relevance to Irradiation Parameters

“…Clinically, the short application time and use of noncorrosive, pH-neutral or alkaline gels is recommended [ 47 ]. Overall, side effects can be minimised with modern desensitising materials [ 48 , 49 ] and techniques [ 50 , 51 ]. Notwithstanding, a general review of the safety of tooth whitening has been published and it is reassuring that the number of clinically reported adverse effects or incidents after bleaching is relatively low [ 52 , 53 , 54 ].…”

Comparative evaluation of the efficacy of the desensitizing and remineralizing agent in the reduction of dentin hypersensitivity after orthodontic debonding - a randomised clinical trial

“…The paste could have stayed on the surface of the tubule, possibly delivering Ca-P particles into the tubules. The tubular ratio and hydraulic pipeline could have been reduced, thus explaining the reduced pain and the drop of VAS values immediately on the application of the agent [ 44 ].…”