Effectiveness-of Calcium Phosphate derivative agents on the prevention and remineralization of caries among children- A systematic review &amp; meta-analysis of randomized controlled trials

Singal, Kusum; Sharda, Sheetal; Gupta, Arpit; Malik, Vivek Singh; Singh, Manvi; Chauhan, Anil; Aggrawal, Amit; Pradhan, Pranita; Singh, Meenu

doi:10.1016/j.jebdp.2022.101746

Cited by 14 publications

(10 citation statements)

References 64 publications

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“…CPP-ACP, a milk protein derivative, was commercially introduced since it has been proven to have anticariogenic effects [17]. CPP stabilizes high concentrations of calcium and phosphate ions with fluoride ions at the tooth surface by binding to pellicle and plaque [18].…”

Section: Introductionmentioning

confidence: 99%

Remineralization Efficacy of Four Remineralizing Agents on Artificial Enamel Lesions: SEM-EDS Investigation

et al. 2022

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Dental remineralization represents the process of depositing calcium and phosphate ions into crystal voids in demineralized enamel, producing net mineral gain and preventing early enamel lesions progression. The aim of the present study was to qualitatively and quantitatively compare the remineralizing effectiveness of four commercially available agents on enamel artificial lesions using Scanning Electron Microscopy (SEM) combined with Energy Dispersive Spectroscopy (EDS) techniques. Thirty-six extracted third molars were collected and randomly assigned to six groups (n = 6), five of which were suspended in demineralizing solution for 72 h to create enamel artificial lesions, and one serving as control: G1, treated with a mousse of casein phosphopeptide and amorphous calcium–phosphate (CPP-ACP); G2, treated with a gel containing nano-hydroxyapatite; G3, treated with a 5% SF varnish; G4, treated with a toothpaste containing ACP functionalized with fluoride and carbonate-coated with citrate; G5, not-treated artificial enamel lesions; G6, not demineralized and not treated sound enamel. G1–G4 were subjected to pH cycling over a period of seven days. Analyses of the specimens’ enamel surfaces morphology were performed by SEM and EDS. Data were statistically analyzed for multiple group comparison by one-way ANOVA/Tukey’s test (p < 0.05). The results show that the Ca/P ratio of the G5 (2.00 ± 0.07) was statistically different (p < 0.05) from G1 (1.73 ± 0.05), G2 (1.76 ± 0.01), G3 (1.88 ± 0.06) and G6 (1.74 ± 0.04), while there were no differences (p > 0.05) between G1, G2 and G6 and between G4 (2.01 ± 0.06) and G5. We concluded that G1 and G2 showed better surface remineralization than G3 and G4, after 7 days of treatment.

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Section: Introductionmentioning

confidence: 99%

Remineralization Efficacy of Four Remineralizing Agents on Artificial Enamel Lesions: SEM-EDS Investigation

et al. 2022

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“…Therefore, adequate consumption of Ca is of crucial importance in maintaining the health, function and retention of teeth and bones [ 20 ]. Singal et al [ 21 ] concluded that topical treatment using calcium phosphate and fluoride (CaP + F) group showed good remineralization potential and the antibacterial effect on dental caries among children. In agreement with the current study, Pratyusha et al [ 22 ] conducted a comparative cross-sectional study on association of serum VD and salivary Ca level in 3-11-year-old schoolchildren with dental caries, indicating that VD deficiency and lower salivary Ca levels may be the potential risk factors for the occurrence of dental caries.…”

Section: Discussionmentioning

confidence: 99%

Combined effect of dietary calcium consumption and physical activity on dental caries in children and adolescents: a study of the NHANES database

Zhang,

Bai,

Jin

et al. 2024

BMC Oral Health

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Background Calcium (Ca) is a nutritional factor that associated with dental caries. A recent study showed that in the case of adequate Ca intake, a higher level of physical activity may contribute to bone mass accumulation. However, the combined effect between Ca intake and physical activity on caries experience is unclear. Herein, we aimed to explore the above combined effect on dental caries in children and adolescents. Methods Data of 5,917 children and adolescents were extracted from the National Health and Nutrition Examination Surveys (NHANES) database in 2015–2020 in this cross-sectional study. The NHANES assessed the dietary Ca intake through the 24-hour dietary recalls, and the physical activity level was self-reported using the questionnaires. Also, the dental caries was diagnosed according to the Decayed, Missing and Filled Teeth/Surfaces (DMFT/S) index. Weighted univariate and multivariate logistic regression analyses were utilized to screen the covariates and to investigate the associations of dietary Ca intake and physical activity with dental caries, respectively, and assess the combined effect between dietary Ca intake and physical activity on dental caries. The evaluation indexes were odd ratios (ORs) and 95% confidence intervals (CIs). Subgroup analyses of age, obesity, and total sugar intake were also performed. Results Among the eligible participants, 2,687 had caries experience. After adjusting for the covariates, we found that children and adolescents who not reach the recommendation level of Ca intake combined with physical activity less than 7 time in 1 week seemed to have higher odds of dental caries [OR = 1.77, 95%CI: (1.38–2.27)], compared with those who reached the standards. In addition, this potential combined effect was also found in age < 12 years old [OR = 1.62, 95%CI: (1.23–2.14)], non-obesity [OR = 1.88, 95%CI: (1.49–2.35)], and total sugar intake (all P < 0.05) subgroups. Conclusions Ca intake and physical activity had a potential combined effect on dental caries in children and adolescents, but the causal relationships between them needed further clarification.

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“…The results of this in vitro study on the remineralisation efficacy of the other biomimetic technologies needs to be assessed in clinical trials as has been conducted for the CPP–ACP technology. [ 32 , 33 , 47 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative Efficacy of Novel Biomimetic Remineralising Technologies

et al. 2023

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Biomimetic technologies for the remineralisation of enamel subsurface lesions (ESLs) have been developed and include: fluorocalcium phosphosilicate bioglass (BG/F); casein phosphopeptide-amorphous calcium phosphate (CPP–ACP) and with fluoride (CPP–ACFP); and self-assembling oligopeptide P11-4 (SAP). The aim of this study was to compare the remineralisation of ESLs in vitro using these technologies. Human enamel slabs with ESLs were cut into two half-slabs; one half-slab was untreated (control), and the other half was treated by exposure to one of the four technologies with artificial saliva (AS) or AS alone for 14 days at 37 °C. The technologies were applied to the ESL surface according to the manufacturer’s instructions. At the completion of each treatment, the treated half-slabs and their paired control half-slabs were embedded, sectioned and the mineral content was determined using transverse microradiography. The change in mineral content (remineralisation) between treatments was statistically analysed using one-way ANOVA. The order from highest to lowest remineralisation was CPP–ACFP (52.6 ± 2.6%) > CPP–ACP (43.0 ± 4.9%) > BG/F (13.2 ± 2.5%) > SAP (5.8 ± 1.6%) > AS (2.1 ± 0.5%). Only CPP–ACFP and CPP–ACP produced remineralisation throughout the body of the lesions. All four biomimetic technologies had some effect on the remineralisation of ESLs; however, CPP–ACFP with calcium, phosphate and fluoride ions stabilised by CPP was superior in the level and pattern of remineralisation obtained.

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Effectiveness-of Calcium Phosphate derivative agents on the prevention and remineralization of caries among children- A systematic review & meta-analysis of randomized controlled trials

Cited by 14 publications

References 64 publications

Remineralization Efficacy of Four Remineralizing Agents on Artificial Enamel Lesions: SEM-EDS Investigation

Remineralization Efficacy of Four Remineralizing Agents on Artificial Enamel Lesions: SEM-EDS Investigation

Combined effect of dietary calcium consumption and physical activity on dental caries in children and adolescents: a study of the NHANES database

Comparative Efficacy of Novel Biomimetic Remineralising Technologies

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