Effectiveness of automated and live phone reminders after mailed-FIT outreach in a pilot randomized trial

Nielson, Carrie M.; Rivelli, Jennifer S.; Fuoco, Morgan J.; Gawlik, Victoria R.; Jiménez, Ricardo; Petrik, Amanda F.; Coronado, Gloria D.

doi:10.1016/j.pmedr.2018.10.012

Cited by 6 publications

(3 citation statements)

References 18 publications

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“…While telephone-based interventions have been shown to promote healthy behaviors in previous research 26 , 27 and are frequently practiced in clinical settings, 28 , 29 we did not observe a difference in TCT enrollment between groups on the basis of receipt of an additional telephone call to discuss the FRP. However, we did find a strikingly high proportion of TCT enrollment in both study arms during the RCT, well above the accepted standard consent rate among patients with cancer.…”

Section: Discussioncontrasting

confidence: 69%

Implementation of a Multisite Financial Reimbursement Program in Cancer Clinical Trials Integrated With Patient Navigation: A Pilot Randomized Clinical Trial

Borno

Zhang

Lin

et al. 2022

JCO Oncology Practice

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PURPOSE: Cancer clinical trial participants face considerable indirect costs associated with participation, such as travel and lodging, which may contribute to poor enrollment. Here, we report the findings in IMproving Patient Access to Cancer clinical Trials, a pilot feasibility study investigating the efficacy of offering a financial reimbursement program (FRP) during a therapeutic clinical trial discussion with or without additional outreach in improving patient enrollment. METHODS: Study participants for this study were recruited at two National Cancer Institute–designated comprehensive cancer centers (CCCs) from April 8, 2019, to September 19, 2019. Eligible participants were adults with a cancer diagnosis being approached to consider enrollment in a clinical trial. Participants were randomly assigned 1:1 to receive no follow-up (usual care) or a follow-up telephone call to facilitate FRP utilization stratified by study site. The target enrollment was 132 patients, with 66 patients in each study arm. The primary outcome was the consent rate to the multisite interventional study on the FRP among participants enrolling in clinical trials. RESULTS: The study had a 78% consent rate and enrolled a total of 132 participants, of whom 51% were non-White compared with 28% of CCC treatment clinical trial participants in 2019. No difference in enrollment in clinical trials between the two study arms was observed as the proportion of enrollment was 70% for both study arms. The most common reason for not enrolling in a clinical trial was due to ineligibility determined through screening procedures (75%). CONCLUSION: The current study observed that implementation of FRP at CCCs is feasible and serves a diverse patient population. Future studies will measure the impact of programs on overall clinical trial accrual and among racial/ethnic minorities.

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Section: Discussioncontrasting

confidence: 69%

Implementation of a Multisite Financial Reimbursement Program in Cancer Clinical Trials Integrated With Patient Navigation: A Pilot Randomized Clinical Trial

Borno

Zhang

Lin

et al. 2022

JCO Oncology Practice

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“…This compares with 81% reach for live phone calls reported by our team in a similar safety net setting and 26%-48% reach in previous published reports. 6,18,[25][26][27] Further improvements in phone call reach might be achieved by increasing the number of call attempts or expanding the hours calls are delivered. The 81% reach we report for text messages was slightly higher than reported in previous studies, where reach ranged from 51% to 78%.…”

Section: Discussionmentioning

confidence: 99%

Randomized Controlled Trial of Advance Notification Phone Calls vs Text Messages Prior to Mailed Fecal Test Outreach

Coronado

Nyongesa

Petrik

et al. 2021

Clinical Gastroenterology and Hepatology

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BACKGROUND & AIMS:Mailing fecal immunochemical test (FITs) to individuals who are due for screening (mailed FIT outreach) increases colorectal cancer (CRC) screening. Little is known about how phone-based advance notifications (primers) affect the effectiveness of mailed FIT outreach programs. METHODS:We performed a prospective study of patients at a large urban health center, 50-75 years old and due for screening, with no record of a prior FIT. Participants were randomly assigned to groups that received a live phone call primer (n [ 1203) or a text message primer (n [ 1622), from June through December 2018. The participants were then mailed a FIT kit, followed by 2 automated calls, and live reminder calls delivered by the care team. The main outcome was completion of FIT within 3 months of assignment to the live phone call or text message group. RESULTS:Participants had a FIT completion rate of 16.8%, a mean age of 58 years, and 80% were Latino.In adjusted intention to treat analyses (n [ 2825), FIT completion rates were higher in the patients assigned to receive a live phone call vs text message primer (percentage point difference, 3.3%; 95% CI, 0.4%-6.2%). Between-group differences increased to 7.3% points (95% CI, 3.6%-11.0%) in the per-protocol analysis of 2144 participants reached by the text message (1320/1622, 81%), live call (438/1203, 36%), or voice message (386/1203, 32%). This rate increased to 14.9% points (95% CI; 9.6%-20.1%) in the per-protocol analysis of 1758 participants reached by the text message or reached by the live call. CONCLUSIONS:In a randomized trial, advance notification live phone calls outperformed text messages in prompting health center patients who had not previously completed a FIT to complete a mailed FIT. Clinicaltrials.gov no: NCT03167125

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“…Phone calls may serve as a valuable prompt and can verify a patient's address and empanelment status in health systems, particularly in underserved communities; however, calls can be a resource-intensive intervention. [8][9][10] While advanced notification calls before FIT outreach are effective, 7,[11][12][13] they may not be necessary for all patients, especially for those more likely to complete a FIT. [14][15][16] Though patients most likely to complete a FIT are those with prior FIT completion, 17,18 studies investigating the effectiveness of pre-FIT advanced notifications did not focus on this subgroup.…”

Section: Introductionmentioning

confidence: 99%

Advanced Notification Calls Prior to Mailed Fecal Immunochemical Test in Previously Screened Patients: a Randomized Controlled Trial

et al. 2020

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BACKGROUND: Phone calls as part of multimodal fecal immunochemical test (FIT) outreach are effective but resource-intensive. Previous studies of advanced notification calls before FIT mailing have not differentiated patients' prior screening status. OBJECTIVE: To determine the effectiveness of a phone call preceding mailing of a FIT kit on test completion rate for patients who have completed a prior FIT. DESIGN: Randomized controlled trial nested within a larger study. All patients were assigned to receive organized mailed FIT outreach in the larger study. PARTICIPANTS: Patients in a safety-net health setting ages 50-75 years old with a previously negative FIT. INTERVENTIONS: Patients were assigned to either receive an advanced notification phone call or no phone call preceding a mailed FIT kit. Both groups received an informational postcard prior to the mailed FIT. MAIN MEASURES: The primary outcome was FIT completion rate at 1 year. The secondary outcomes were FIT completion rates at 60, 90, and 180 days, rates stratified by demographic subgroups, and rates according to outcome of the phone call. KEY RESULTS: A total of 1645 patients were assigned to advanced notification calls and 1595 were assigned to no call preceding the FIT mailing. Although FIT completion rate was higher at day 60 (55.5% vs. 50.8%, p < 0.01), an advanced notification call did not significantly improve FIT completion at 1 year (70.9% vs. 69.9%, p = 0.52). Of the patients assigned to receive an advanced notification call, 90.5% were spoken with or left a voicemail; patients who were spoken with were more likely to complete a FIT at 1 year compared with patients who were only left a voicemail or could not be left a voicemail (79.9% vs. 69.2% vs. 49.6%, p < 0.01).CONCLUSIONS: Advanced notification phone calls prior to FIT mailing did not improve rates at 1 year for patients with a previously negative FIT.

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Effectiveness of automated and live phone reminders after mailed-FIT outreach in a pilot randomized trial

Cited by 6 publications

References 18 publications

Implementation of a Multisite Financial Reimbursement Program in Cancer Clinical Trials Integrated With Patient Navigation: A Pilot Randomized Clinical Trial

Implementation of a Multisite Financial Reimbursement Program in Cancer Clinical Trials Integrated With Patient Navigation: A Pilot Randomized Clinical Trial

Randomized Controlled Trial of Advance Notification Phone Calls vs Text Messages Prior to Mailed Fecal Test Outreach

Advanced Notification Calls Prior to Mailed Fecal Immunochemical Test in Previously Screened Patients: a Randomized Controlled Trial

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