Effectiveness of Antihypertensive Agents Among Hypertensive Patients of Nepal

Abstract

These investigations compare the effectiveness of antihypertensive agents among hypertensive patients. It was an open label, prospective and comparative study carried out in the Out-patient department at BPKIHS, Dharan, Sunsari, Nepal. Patients of either sex aged between 25-80 years suffering from mild to moderate hypertension were randomly selected. In this study indicate various types of antihypertensive drugs for the management of hypertension like Calcium channel blockers (amlodipine), Angiotensin Converting enzyme inhibitors (Enalpril), beta adrenergic blocker (metoprolol, propranolol, atenolol), Angiotension receptor blocker (Losartan), Diuretics (Spironolactone, Furesomide). In this study, out of 40 patients of stage 1 hypertension: 18 % patients were treated with ARBs, 30 % patients were treated with CCBs, 15 % patients with CCBs + diuretics, 8 % patients with β-blockers + ARBs, 10 % with ACE inhibitors and 12.5 % patients were treated with β -blockers + CCBs. Similarly, out of 15 patients of stage 2 hypertensive patients, 6 % patients were treated with ARBs + diuretics, 13 % patients with ARBs + β blockers, 20 % with CCBs + diuretics, 20 % with β blockers + ACE inhibitors and 40 % patients were treated with CCBs + ARBs. Three drug combined therapy is more effective as compared to two drug combined therapy and mono therapy. In this study, male hypertensive patients were observed more susceptible with severe hypertension as compared to female hypertensive patients. The reason corresponding to this statement might be more stressful life style and frequent smoking habit as well as more alcohol consumption habit of male as compared to female.

Comparison of Efficacy and Adverse Drug Reactions of Monotherapy Versus Combination Therapy of Antihypertensives Among Diabetic Hypertensive Patients in a Tertiary Care Hospital

“…In the present study, there was male preponderance in patients having HTN with diabetes (54% [17,20,[22][23][24]. This could probably be due to significantly higher awareness, treatment, and control rates among women than men as supported by a recent data from the 2007 to 2010 National Health and Nutrition Examination Survey [25].…”

“…However, most of the other studies had shown an inconsistent finding with the present study in relation to the most common 2-drug combination drugs prescribed. Tamuno and Fadare and Pandaya et al reported that the most commonly used 2-drug combination was CCB + diuretic (12% and 37.8%, respectively) [23,28]. According to Kausalya et al, ACE inhibitor + CCB was the most commonly prescribed 2-drug combination, whereas in a study by Jaganan et al, ACE inhibitors…”

Assessment of Drug Utilization Pattern and Rational Use of Antihypertensive Therapy in Geriatric Patients: A Prospective Observational Study

“…Among two drug regimen CCB+ Diuretics combination are generally prescribed. Similarly, Pandaya et al found that the most generally prescribed two-drug combination was CCB+ Diuretic (12 percent and 37.8%, respectively) 8 . In this study, 32.07 percent (n=34) of the participants were administered a three-drug antihypertensive medication regimen.…”