Effectiveness of Antibiotic Use Management in Tianjin (2011–2013): A Quasi-Experimental Study

Abstract

BackgroundIn this study we investigated changes in the status of antibiotic use in Tianjin since the implementation of the Antibiotic Stewardship Program (ASP) (2011–2013), as well as existing problems, strategies, and outcomes to promote rational clinical antibiotic use.Material/MethodsA quasi-experimental study was performed to investigate situations of antibiotic use in secondary and tertiary general hospitals in Tianjin from April 2011 to 2013. Five major indicators were analyzed: percentage of antibiotic use in inpatient cases (%), antibacterial use density (AUD), proportion of prophylactic antibiotic application for type I surgical incision, compliance rate of medication administration 0.5–2.0 h before such procedures, and antibiotic prophylaxis for ≤24 h in patients receiving these surgeries.ResultsThere was a decrease in the percentage of antibiotic use across general hospitals (60.38% to 46.88%), in AUD (51.60% to 35.37%), and in the proportion of prophylactic antibiotic applications for type I incisions (86.67% to 25.08%). For patients undergoing these procedures, there was an increased compliance rate of medication administration of 0.5–2.0 h prior to surgery (86.38% to 100%), and of antibiotic prophylactic use for ≤24 h (40.30% to 96.37%).ConclusionsImplementation of the ASP campaign has reduced irrational antibiotic use, promoted rational antibiotic use, and delayed antibiotic resistance.

Interventions to Reduce Antibiotic Prescribing in LMICs: A Scoping Review of Evidence from Human and Animal Health Systems

“…Organisational/Management Strategies Stewardship programme : Comprehensive stewardship campaigns using multiple approaches resulted in substantial reductions in antibiotic use and sales in both hospitals and pharmacies. Kallel et al [81], Ma et al [82], Ozkurt et al [83], and Zhang et al [84] evaluated effects of stewardship programme at secondary or tertiary hospitals while Marković-Peković et al [85] studied effects at pharmacies. The interventions involved: The formation of expert interdisciplinary groups to provide oversight and guidance, knowledge dissemination, clinical training, academic engagement (e.g., participation in conferences and seminars), monitoring, feedback, data management and verification, the development of new guidelines and targets and financial penalties.…”

Quality of Antibiotic Prescribing for Respiratory Tract Disease in Primary Healthcare Centers in the District of Tegal, Central Java, Indonesia

“…The minimum sample target was set to 214 antibiotic prescriptions. 16 Purposive sampling method was employed to collect the samples, followed by selection of prescriptions for diagnosed respiratory tract diseases to be analyzed qualitatively (Figure 1). Data in the prescriptions consisted of patient's name, age, diagnosis, prescriber, name of drugs, and administered regimen.…”