Effectiveness of antibiotic combination therapy in patients with active ulcerative colitis: A randomized, controlled pilot trial with long-term follow-up

Ohkusa, Toshifumi; Nomura, Tetsuya; Terai, Takeshi; Miwa, Hiroto; Kobayashi, Osamu; Hojo, Mariko; Takei, Yoshiyuki; Ogihara, Tatsuo; Hirai, Shu; Okayasu, Isao; Sato, Nobuhiro

doi:10.1080/00365520510023648

Cited by 79 publications

(67 citation statements)

References 25 publications

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“…In a study of 2 weeks of antibiotic therapy (amoxicillin, tetracycline, or metronidazole) specifi cally directed against Fusobacterium varium , clinical activity and endoscopic and histologic scores of UC patients who received active treatment were signifi cantly reduced at 3 -5 and 12 -14 months aft er the end of treatment ( 63 ). Notably, reductions in the titer of antibody to F. varium appeared to correlate to these improvements.…”

Section: Therapeutic Approachesmentioning

confidence: 98%

Intestinal Microbes in Inflammatory Bowel Diseases

Sartor¹,

Mazmanian²

2012

Am J Gastroenterol Suppl

181

152

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Section: Therapeutic Approachesmentioning

confidence: 98%

Intestinal Microbes in Inflammatory Bowel Diseases

Sartor¹,

Mazmanian²

2012

Am J Gastroenterol Suppl

181

152

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“…Evidence implicating the resident enteric microflora in the pathogenesis of spontaneous IBD in people is provided by the increased immune responses to enteric commensal bacteria observed in both Crohn's disease (CD) and ulcerative colitis (UC) (1,24,45,52,54), the clinical responses of CD and UC to antimicrobials (9,10,48,58,70) and the response of CD to fecal stream diversion (68). The discovery of genetic defects in the microflora-sensing ability of patients with CD and UC, such as NOD2/CARD15 and TLR-4, respectively, provides mechanisms to explain individual susceptibility to the resident microflora (33,46).…”

mentioning

confidence: 99%

Adherent and InvasiveEscherichia coliIs Associated with Granulomatous Colitis in Boxer Dogs

Simpson¹,

Dogan²,

Rishniw³

et al. 2006

Infect Immun

232

320

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The mucosa-associated microflora is increasingly considered to play a pivotal role in the pathogenesis of inflammatory bowel disease. This study explored the possibility that an abnormal mucosal flora is involved in the etiopathogenesis of granulomatous colitis of Boxer dogs (GCB). Colonic biopsy samples from affected dogs (n ‫؍‬ 13) and controls (n ‫؍‬ 38) were examined by fluorescent in situ hybridization (FISH) with a eubacterial 16S rRNA probe. Culture, 16S ribosomal DNA sequencing, and histochemistry were used to guide subsequent FISH. GCB-associated Escherichia coli isolates were evaluated for their ability to invade and persist in cultured epithelial cells and macrophages as well as for serotype, phylogenetic group, genome size, overall genotype, and presence of virulence genes. Intramucosal gram-negative coccobacilli were present in 100% of GCB samples but not controls. Invasive bacteria hybridized with FISH probes to E. coli. Three of four GCB-associated E. coli isolates adhered to, invaded, and replicated within cultured epithelial cells. Invasion triggered a "splash"-type response, was decreased by cytochalasin D, genistein, colchicine, and wortmannin, and paralleled the behavior of the Crohn's disease-associated strain E. coli LF 82. GCB E. coli and LF 82 were diverse in serotype and overall genotype but similar in phylogeny (B2 and D), in virulence gene profiles (fyuA, irp1, irp2, chuA, fepC, ibeA, kpsMII, iss), in having a larger genome size than commensal E. coli, and in the presence of novel multilocus sequence types. We conclude that GCB is associated with selective intramucosal colonization by E. coli. E. coli strains associated with GCB and Crohn's disease have an adherent and invasive phenotype and novel multilocus sequence types and resemble E. coli associated with extraintestinal disease in phylogeny and virulence gene profile.

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“…Among UC patients, there is evidence for ulcer invasion by and increased concentrations of the butyrate producing species, Fusobacterium varium [98]. This potential etiologic role of Fusobacterium varium is supported by evidence suggesting efficacy from two weeks of combination therapy with amoxicillin, tetracycline, and metronidazole in UC patients for eradication of the bacteria [99]. In contrast, CD patients have shown a consistent decrease in Faecalibacterium prausnitzii, another predominant butyrate producer [65].…”

Section: Genetic and Microbial Interactions In Inflammatory Bowel Dismentioning

confidence: 83%

Nature vs. Nurture: The Gut Microbiome and Genetics in the Development of Gastrointestinal Disease

Ec¹,

Da²

2016

J Hepatol Gastroint Dis

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Effectiveness of antibiotic combination therapy in patients with active ulcerative colitis: A randomized, controlled pilot trial with long-term follow-up

Abstract: The 2-week antibiotic combination therapy against F. varium was effective and safe in patients with chronic, active ulcerative colitis in this long-term follow-up study.

Cited by 79 publications

References 25 publications

Intestinal Microbes in Inflammatory Bowel Diseases

Intestinal Microbes in Inflammatory Bowel Diseases

Adherent and InvasiveEscherichia coliIs Associated with Granulomatous Colitis in Boxer Dogs

Nature vs. Nurture: The Gut Microbiome and Genetics in the Development of Gastrointestinal Disease

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