Effectiveness of allopurinol on triglyceride levels in hyperuricemic patients

Abstract

INTRODUCTIONHyperuricemia occurs at concentration of uric acid of 416mmol/L, but there are authors that consider the normal values of uric acid to be its values of 392mmol/L for female, and 458mmol/L for male. 1 It should be noted that men excrete smaller amounts of uric acid than women and therefore more commonly suffer from hyperuricemia.2 The reason lies in the fact that women in the reproductive age have lower serum uric acid values due to the estrogen effect in the form of enhanced uric acid excretion and inhibition of the renal reabsorption of uric acid. The concentration of serum uric acid is one of the potential markers of cardiovascular and cerebrovascular diseases and therefore this type of clinical research is very important. 4There are some examples of connectivity hyperuricemia and hypertension in humans. Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Background:In this clinical pharmacological research, we dealt with the action of allopurinol on triglyceride levels in hyperuricemic patients. Methods: The study included 40 hyperuricemic patients, of both genders and different age groups, that were sorted by comorbid diagnoses in several subgroups. All patients were clinically treated in the period of three years both at UCC Sarajevo, and P.I. General Hospital "Abdulah Nakaš" Sarajevo. All clinical measurements were carried out using standard IFCC methods with the appropriate analysers. Results: The study was based on mean triglyceride levels before and after three and six months of treatment with allopurinol. It was found out that the mean triglyceride levels were not significantly different from the reference values prior to treatment (p = 0.846) and after three months of therapy (p=0.153). In contrast, after six months of treatment, triglyceride levels significantly increased compared to the reference values. In patients with a diagnosis of gout and metabolic syndrome, triglycerides were statistically significantly increased during the six months of observation. A statin group of patients showed a statistically significant increase in triglyceride levels after three months of therapy (p = 0.032), while, after six months their levels had decreased (p = 0.029). In patients with diabetes mellitus type II, triglycerides rose after three months of treatment (p = 0.039) and retained the same level after six months of observation. Conclusions:The analysis shows that the use of allopurinol has an effect on triglyceride levels in hyperuricemic patients.

Comparison of the Effects of Allopurinol and Febuxostat on the Values of Triglycerides in Hyperuricemic Patients

“…A significant increase in triglyceride values was observed after three and six months of allopurinol use. In the study conducted by Žiga and associates, the mean value of triglycerides was not significantly different compared to their initial value (p = 0.846), as well as after three months of allopurinol use (p = 0.153), whereas after six months, the mean value of triglycerides was significantly higher compared to their initial value (p = 0.047) ( 9 ). The results of the research presented in this paper demonstrated a direct correlation between serum triglyceride values and hyperuricemia in patients with metabolic syndrome.…”

“…Correlation between serum urate and lipid values is interesting, but the results of some studies regarding this are contradictory. Certain studies have shown a significant link between serum lipid values and hyperuricemia in the examinees with metabolic syndrome, with triglycerides, total cholesterol and high-density lipoprotein (HDL) being positively and low-density lipoprotein (LDL) negatively correlated with hyperuricemia ( 5 - 9 ). Some studies on animal models have shown a significant link between serum uric acid and triglyceride values ( 10 , 11 ).…”