Effectiveness of air purifier on health outcomes and indoor particles in homes of children with allergic diseases in Fresno, California: A pilot study

Park, Hye Kyung; Cheng, Kai-Chung; Tetteh, Afua O.; Hildemann, Lynn M.; Nadeau, Kari

doi:10.1080/02770903.2016.1218011

Cited by 65 publications

(58 citation statements)

References 19 publications

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“…According to the available studies, nasal application of mometasone or oral application of montelukast reduces the intensity of mild obstructive sleep apnea in children [65,66]. Another way of alleviating the symptoms of nasal obstruction may be the use of household air filters [67]. However, so far, no studies analyzing the direct impact of air filters on obstructive sleep apnea have been conducted.…”

Section: Allergic Diseases Environmental Pollution and Osamentioning

confidence: 99%

Environmental Factors as Modulators of the Relationship between Obstructive Sleep Apnea and Lesions in the Circulatory System

Urbanik

Martynowicz

Mazur

et al. 2020

JCM

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Obstructive sleep apnea (OSA) is a growing social problem, particularly in well-developed countries. It has been demonstrated that obstructive sleep apnea is a significant risk factor for cardiovascular diseases, including arterial hypertension, ischemic heart disease, heart failure, rhythm/conduction disturbances, as well as cerebral stroke. The pathophysiology of these diseases is complex and multifactorial. We present the current state of research on behavioral and environmental factors that influence the relationship between OSA and cardiovascular changes. We discuss the relationship between obesity, alcohol, sedatives, environmental tobacco smoke, allergic diseases and environmental pollution on the one hand and OSA on the other. In this context, the environment should be considered as an important modulator of the relationship between OSA and cardiovascular diseases.

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Section: Allergic Diseases Environmental Pollution and Osamentioning

confidence: 99%

Environmental Factors as Modulators of the Relationship between Obstructive Sleep Apnea and Lesions in the Circulatory System

Urbanik

Martynowicz

Mazur

et al. 2020

JCM

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“…Of the seven eligible studies, six were randomized controlled trials (14,15,(23)(24)(25)(26) and one was a randomized cross-over study (27). The study population included asthmatics (14,15,(23)(24)(25)(26) and patients with COPD (27); the study about interstitial lung disease or bronchiectasis was not identified.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…Six of the identified studies were conducted in North America (14,15,(23)(24)(25)(26); the remaining study was conducted in Beijing, China (27).…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…Therefore, the pooled estimate was calculated with an absolute difference in means. Five of included studies (15,23,25,26,28) used high-efficiency particulate air (HEPA) filter which can eliminate PM 2.5 more than 99.9% and two of included studies did not describe a filter model (24, 27) (Supplement Table 3). All enrolled studies reported that air filers resulted in a significant reduction in PM 2.5 (Fig.…”

Section: Effect Of Air Filters On Particulate Mattermentioning

confidence: 99%

“…Sublett et al performed a systemic review of studies published up to 2010, focusing on the effect of air filters on allergic disease, however, health outcomes were not consistent and the study did not consider the concentration of PM (13). Some studies also showed that air filters can have a beneficial effect on respiratory symptoms in patients with asthma (14,15). The impact of PM is prominent in patients with chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma (16).…”

Section: Introductionmentioning

confidence: 99%

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The effect of particulate matter reduction by indoor air filter use on respiratory symptoms and lung function: A systemic review and meta-analysis

Park

Lee

Suh

et al. 2020

Preprint

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BackgroundExposure to particulate matter (PM) is a key public health issue, but effective intervention has not yet been established. A systematic literature review and meta-analysis has been conducted to assess the relationship between the use of air filters, one of the most-studied interventions, and respiratory outcomes in patients with chronic respiratory disease.MethodsWe systemically reviewed intervention studies on PM using Pubmed, EMBASE, and Cochrane databases up to September 2019. Studies that included data on PM level changes and respiratory symptoms or lung function in patients with respiratory diseases were eligible for inclusion. Effect estimates were quantified separately using the random-effects model.ResultsSeven studies were included in our study. Air filter use reduced indoor PM2.5 by 11.45 µg/m3 (95% confidence interval [CI]: 6.88–16.01 µg/m3). Air filter use improved predicted forced expiratory volume in one second (FEV1) by 3.60% (95% CI: 0.29–6.90%). Air filter use was not associated with a significant change in respiratory symptoms (odds ratio: 0.82; 95% CI: 0.62–1.08).ConclusionThe findings from this systematic review suggest that a role for air filter with respect to reduced indoor PM and increased lung function. Further studies in high density PM regions may provide additional information on this role.Systematic review registration: PROSPERO: on review ID 156258

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Association Between Bedroom Particulate Matter Filtration and Changes in Airway Pathophysiology in Children With Asthma

Cui

Teng

et al. 2020

JAMA Pediatr

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IMPORTANCE Fine particles (particulate matter 2.5 μm [PM 2.5 ]), a ubiquitous air pollutant, can deposit in the small airways that play a vital role in asthma. It appears to be unknown whether the use of a PM 2.5 filtration device can improve small airway physiology and respiratory inflammation in children with asthma.OBJECTIVE To discover what pathophysiological changes in the small airways are associated with using a PM 2.5 -removing device in the bedrooms of children with asthma. DESIGN, SETTING, AND PARTICIPANTSChildren with mild or moderate asthma were enrolled in this double-blind, crossover study. The participants used a true filtration device and a sham filtration device in their bedrooms in a random order for 2 weeks each with a 2-week washout interval. The study was conducted in a suburb of Shanghai, China, during a low-ozone season.EXPOSURES Ozone and PM 2.5 were measured inside bedrooms and outside a window.MAIN OUTCOMES AND MEASURES Impulse oscillometry, spirometry, and fractional exhaled nitric oxide were measured at the beginning and the end of each intervention. Peak expiratory flow was measured twice daily at home. RESULTS Forty-three children (5-13 years old; 26 boys [60%]) participated. Outdoor 24-hour mean PM 2.5 concentrations were moderately high, ranging from 28.6 to 69.8 μg/m 3 (median, 53 μg/m 3 ). During true filtration, bedroom PM 2.5 concentrations were a mean (SD) of 63.4% (35.9%) lower than during sham filtration. Compared with sham filtration, true filtration was significantly associated with improved airway mechanics, reflected in a 24.4% (95% CI, 11.8%-37.1%) reduction in total airway resistance, a 43.5% (95% CI, 13.7%-73.3%) reduction in small airway resistance, a 22.2% (95% CI, 2.2%-42.2%) reduction in resonant frequency, and a 73.1% (95% CI, 0.3%-145.8%) increase in airway reactance. True filtration was also associated with significant improvements in fractional exhaled nitric oxide (a 27.6% [95% CI, 8.9%-42.4%] reduction) and peak expiratory flow (a 1.6% [95% CI, 0.8%-2.5%] increase). These improvements were significantly associated with bedroom PM 2.5 reduction. Improvements in small airway function were nonsignificant (8.4% [95% CI, −1.4% to 18.3%]) in all participants but significant (13.2% [95% CI, 1.2%-25.1%]) in participants without eosinophilic airway inflammation at baseline. No improvements were observed for forced vital capacity, forced expiratory volume during the first second, and the ratio of these in all participants or subgroups.CONCLUSIONS AND RELEVANCE Per these results, indoor PM 2.5 filtration can be a practical method to improve air flow in an asthmatic lung through improved airway mechanics and function as well as reduced inflammation. This warrants a clinical trial to confirm.

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Effectiveness of air purifier on health outcomes and indoor particles in homes of children with allergic diseases in Fresno, California: A pilot study

Abstract: Intervention with air purifiers reduces indoor PM levels with significant improvements in nasal symptoms in children with allergic rhinitis in Fresno.

Cited by 65 publications

References 19 publications

Environmental Factors as Modulators of the Relationship between Obstructive Sleep Apnea and Lesions in the Circulatory System

Environmental Factors as Modulators of the Relationship between Obstructive Sleep Apnea and Lesions in the Circulatory System

The effect of particulate matter reduction by indoor air filter use on respiratory symptoms and lung function: A systemic review and meta-analysis

Association Between Bedroom Particulate Matter Filtration and Changes in Airway Pathophysiology in Children With Asthma

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