Effectiveness of Acupuncture as Adjunctive Therapy in Osteoarthritis of the Knee

Berman, Brian M.; Lao, Lixing; Langenberg, Patricia; Lee, Wen Lin; Gilpin, Adele M. K.; Hochberg, Marc C.

doi:10.7326/0003-4819-141-12-200412210-00006

Cited by 528 publications

(309 citation statements)

References 25 publications

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“…Harris and colleagues [14] found that 3 acupuncture sessions weekly provided more pain relief than 1 session weekly (p = 0.039). Another research group [36] discovered that the difference between sham and true acupuncture for pain was not evident at 8 weeks but was statistically significant at 14 weeks. Our study will help to clarify issues of how long and the pattern of change needed for change in the study outcomes.…”

Section: Discussionmentioning

confidence: 99%

Acupressure for persistent cancer-related fatigue in breast cancer survivors (AcuCrft): a study protocol for a randomized controlled trial

Zick

Wyatt

Murphy

et al. 2012

BMC Complement Altern Med

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BackgroundDespite high levels of clinically significant persistent cancer related fatigue in breast cancer survivors few treatments are currently available and most pose a significant burden on the part of the woman. Acupressure, a component of Traditional Chinese Medicine, has been shown to decrease fatigue levels by as much as 70% in cancer survivors while being inexpensive, non-toxic and an easy to use intervention. The primary aim of this study was to determine the efficacy of two types of self-administered acupressure (relaxation acupressure and stimulating acupressure), compared to standard of care on fatigue severity. Secondary aims were to evaluate the efficacy of two types of acupressure on sleep and kinetic parameters required for implementation of acupressure in a clinical setting; The purpose of this paper is to share the methodology used including challenges and insights.Methods/designThis study is a three group, randomized clinical trial. 375 breast cancer survivors at least 12 months after completion of cancer treatments, with moderate to severe persistent fatigue, are being randomized to one of 3 groups: self-administered relaxation acupressure; self-administered stimulating acupressure; or standard of care. Participants are assessed at baseline, 3 weeks, and 6 weeks followed by a 4-week follow-up period. The primary aim is to examine the effect of 6-weeks of relaxation acupressure compared to stimulatory acupressure or standard of care on fatigue as assessed by: weekly self-report using the Brief Fatigue Inventory; objective daytime physical activity on actigraph; or fatigue patterns assessed 4-times daily using a visual analog scale. Secondary endpoints include depression, anxiety, self-efficacy, and sleep quality.DiscussionThis study has the potential to develop a low-cost, self-care intervention for the most troubling of late-term effects in breast cancer populations, fatigue. The methods used may lend constructive ideas to other investigators working with this population and/or intervention.Trial registrationClinicalTrial.Gov Trials Register NCT01281904

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Section: Discussionmentioning

confidence: 99%

Acupressure for persistent cancer-related fatigue in breast cancer survivors (AcuCrft): a study protocol for a randomized controlled trial

Zick

Wyatt

Murphy

et al. 2012

BMC Complement Altern Med

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“…All studies but 1 (42) were published in English. We obtained unpublished data from 8 authors (outcome data [43,[45][46][47][48] and methodological information [35,36,41,46]). …”

Section: Study Characteristicsmentioning

confidence: 99%

“…These adequacy assessments were partially unblinded because the assessors were already aware of the identity and results of 3 trials (36,43,45). Among the 7 RCTs that included a sham control, we considered the 4 (43,(45)(46)(47) with the highest internal validity ratings on the Cochrane Back Review Group scale (Table) to make up the bulk of the evidence for our review. All 4 RCTs were published since 2004 in the world's leading health care journals.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…All 4 RCTs were published since 2004 in the world's leading health care journals. Three of the 4 also included a nonacupuncture control group (43,45,47). Only 2 of the 4 had any obvious methodological flaws, which were due to higher dropout rates in the sham group for 1 RCT (46) and in the usual care group for the other RCT (43).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Three (36,43,46) were funded by government grants, 1 (44) by a university, and 3 (45,47,48) by health insurance companies.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Meta-analysis: Acupuncture for Osteoarthritis of the Knee

et al. 2007

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Massage Therapy for Osteoarthritis of the Knee

Perlman¹,

Sabina²,

Williams³

et al. 2006

Arch Intern Med

134

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Background: Massage therapy is an attractive treatment option for osteoarthritis (OA), but its efficacy is uncertain. We conducted a randomized, controlled trial of massage therapy for OA of the knee. Methods: Sixty-eight adults with radiographically confirmed OA of the knee were assigned either to treatment (twice-weekly sessions of standard Swedish massage in weeks 1-4 and once-weekly sessions in weeks 5-8) or to control (delayed intervention). Primary outcomes were changes in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and functional scores and the visual analog scale of pain assessment. The sample provided 80% statistical power to detect a 20-point difference between groups in the change from baseline on the WOMAC and visual analog scale, with a 2-tailed ␣ of .05. Results: The group receiving massage therapy demonstrated significant improvements in the mean (SD) WOMAC global scores (−17.44 [23.61] mm; PϽ.001), pain (−18.36 [23.28]; PϽ.001), stiffness (−16.63 [28.82] mm; PϽ.001), and physical function domains (−17.27 [24.36] mm; P Ͻ.001) and in the visual analog scale of pain assessment (−19.38 [28.16] mm; PϽ.001), range of motion in degrees (3.57 [13.61]; P=.03), and time to walk 50 ft (15 m) in seconds (−1.77 [2.73]; PϽ.01). Findings were unchanged in multivariable models controlling for demographic factors. Conclusions: Massage therapy seems to be efficacious in the treatment of OA of the knee. Further study of cost effectiveness and duration of treatment effect is clearly warranted.

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Effectiveness of Acupuncture as Adjunctive Therapy in Osteoarthritis of the Knee

Abstract: Acupuncture seems to provide improvement in function and pain relief as an adjunctive therapy for osteoarthritis of the knee when compared with credible sham acupuncture and education control groups.

Cited by 528 publications

References 25 publications

Acupressure for persistent cancer-related fatigue in breast cancer survivors (AcuCrft): a study protocol for a randomized controlled trial

Acupressure for persistent cancer-related fatigue in breast cancer survivors (AcuCrft): a study protocol for a randomized controlled trial

Meta-analysis: Acupuncture for Osteoarthritis of the Knee

Massage Therapy for Osteoarthritis of the Knee

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