Effectiveness of a Simply Designed Tumor Vaccine in Prevention of Malignant Melanoma Development

Dendritic cells incubated with irradiated tumor cells effectively stimulate T lymphocyte activation and induce enhanced expression of CD69, CD25 as well as production of IFNγ and IL4

“…The experiments were based on our previous reports about the effective protection of animals against the tumor growth by the very same tumor vaccine [12,15].…”

“…As the nonspecific immunomodulator we chose the MVE-2 due to its superiority to some other nonspecific immunomodulators (e.g. BCG, MDP) in triggering of the anti-tumor immune response in combination with irradiated tumor cells [12]. The aim of this study was thus to determine the capability of DC stimulated through the irradiated tumor cells and MVE-2 in inducing the activation of T cells.…”