Effectiveness of a new perforated 0.15 mm poly-p-dioxanon-foil versus titanium-dynamic mesh in reconstruction of the orbital floor

Dietz, Andreas; Ziegler, C.; Dacho, Andreas; Althof, F.; Conradt, Christian; Kolling, G. H.; Boehmer, H. von; Steffen, Heimo

doi:10.1054/jcms.2000.0188

Cited by 65 publications

(38 citation statements)

References 16 publications

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“…These three biomaterials are widely used in maxillofacial trauma as reconstruction of orbital floor fracture and in craniofacial surgery to reconstruct cranial base. [28][29][30][31] Beriplast represents an absorbable natural polymer. Fibrin glue (Beriplast) has been used widespreadly in operative medicine more than 20 years and is used for one or more purposes in surgical repair: Tissue welding, hemostatic agent, fluid barrier, and space filling growth matrix.…”

Section: Discussionmentioning

confidence: 99%

“…32 Titanium mesh represents a metal group and is used in cranioplasty or reconstructions of orbital floor fracture. 29,33 Primary HOB-like cells were used as they are representative of the cell type in contact with the material in vivo. The source of the cell for cultivation in vitro is of great importance for the development of transplanted substitutes.…”

Section: Discussionmentioning

confidence: 99%

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Comparative in vitro study of the proliferation and growth of human osteoblast‐like cells on various biomaterials

Itthichaisri

Wiedmann-Al-Ahmad

Huebner

et al. 2007

J Biomedical Materials Res

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In vitro studies about the growth behavior of osteoblasts onto biomaterials is a basic knowledge and a screening method for the development and application of scaffolds in vivo. In this in vitro study human osteoblast-like (HOB) cells were cultured on seven different biomaterials used in dental and craniomaxillofacial surgery, respectively. The tested biomaterials were synthetic biodegradable (MacroPore, Ethisorb, PDS, Beriplast P) and nonbiodegradable polymers (Palacos) as well as calcium phosphate cement (BoneSource) and titanium. The cell proliferation and cell colonization were analyzed by scanning electron microscopy and EZ4U-test. Statistical analysis were performed. HOB-like cells cultivated on Ethisorb showed the highest proliferation rate. The proliferation rate was statistically significant compared with Palacos, MacroPore, and BoneSource. Whereas, Beriplast, PDS, and titanium yielded lower proliferation rates. However, there was no statistically significant difference compared with Palacos, MacroPore, and BoneSource. SEM analysis showed no significant difference in individual cell features and cell colonization. But an infiltration and a growth of HOB-like cells throughout the porous structure of Ethisorb, which is formed by crossing fibers, is a striking different feature (macrotopography). This feature can explain the highest proliferation rate of Ethisorb. The results showed that HOB-like cells appear to be sensitive to substrate composition and topography. Moreover, the basis for further studies with such biomaterial/osteoblast constructs in vivo are provided. Further focusing points are developing techniques to fabricate three-dimensional porous biomaterial/cell constructs, studying the tissue reaction and the bone regeneration of such constructs compared with the use of autologous bone.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparative in vitro study of the proliferation and growth of human osteoblast‐like cells on various biomaterials

Itthichaisri

Wiedmann-Al-Ahmad

Huebner

et al. 2007

J Biomedical Materials Res

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“…Other authors concluded that the titanium plate or mesh alone was an effective and safe reconstruction material. [25][26][27] Gear et al 25 showed, in a clinical study with 67 reconstructed orbital fractures with a titanium mesh, good functional results and minimal risk for infection. As the titanium is a nonresorbable material, there is no potential for replacement by host tissue.…”

Section: Discussionmentioning

confidence: 99%

In vivo efficacy of bone‐marrow‐coated polycaprolactone scaffolds for the reconstruction of orbital defects in the pig

et al. 2003

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Alloplastic materials offer a number of advantages over bone autografts in the reconstruction of craniofacial defects. These include: lack of donor site morbidity, unlimited quantities of available material, and the possibility to conform exactly to the defect. An ideal bioresorbable material would degrade slowly, and have osteoconductive properties to allow replacement and remodeling by osseous tissue. This is seldom observed, the materials instead being replaced by fibrous tissue. Polycaprolactone (PCL), an FDA-approved bioresorbable polymer, has several properties that might make it suitable for reconstruction of craniofacial defects. The technique of fused deposition modeling (FDM) allows for the fabrication of highly reproducible bioresorbable 3D scaffolds. The nature of the fully interconnected pore network might enhance vascular ingrowth and osteoconductive properties. It was hypothesized that coating the scaffolds in bone marrow might enhance bone formation due to the osteoinductive nature of the bone-marrow mesenchymal cells. This study aimed to test these hypotheses in the pig model. Defects measuring 2 x 2 cm were surgically created in each orbit of eight Yorkshire pigs. The orbits were divided into three groups: Group 1 (n=4), no reconstruction (control); Group 2 (n=6), reconstruction with no coated PCL scaffolds; and Group 3 (n=6) reconstruction with bone-marrow-coated PCL scaffolds. The results were evaluated at 3 months by histological and histomorphometric analyses. The defects in Group 1 were covered with fibrous scar tissue. The shape of the reconstructed area was insufficient. The defects in Groups 2 and 3 were reconstructed correctly. In Group 2 the noncoated scaffolds showed 4.5% of new bone formation compared with 14.1% in Group 3, which is statistically significant (p<0.05). The entirely interconnected 3D polycaprolactone scaffold seems to be a promising material. It induces the bone ingrowth required for reconstructing craniofacial and orbital defects. Further long-term evaluations of these PCL scaffolds must be made in order to confirm these conclusions.

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“…), [26][27][28][29][30][31] allogenic grafts, [32,33] and alloplastic materials (silicone, polytetrafluoroethylene, hydroxylapatite, porous polyethylene, titanium, and Vitallium mesh). [34][35][36][37][38][39][40][41] There are studies outlining their advantages, disadvantages and success rates. Cadaver-based allogenic bone grafts are not preferred due to risk of viral infection transmission, resorption rate and their costly nature.…”

Section: Discussionmentioning

confidence: 99%

Clinical management and reconstruction of isolated orbital floor fractures: The role of computed tomography during preoperative evaluation

Baser¹,

Bulutoğlu²,

Celebi³

et al. 2011

Ulus Travma Acil Cerrahi Derg

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AMAÇİzole orbita taban kırıklarının cerrahi endikasyonu, zamanlaması, kullanılacak rekonstrüksiyon materyali hakkında halen görüş birliği yoktur. GEREÇ VE YÖNTEM2002-2010 yılları arasında izole orbita taban kırığı tanısı alarak ameliyat edilen hastalar (41 erkek, 13 kadın) geriye dönük olarak değerlendirildi. BULGULARİzole orbita taban kırığı tanısı alan 54 hastadan, ameliyat edilen 49 hastanın cerrahi endikasyonuna bakıldığında, %20,4'ünde göz hareketlerinde kısıtlılık ve belirgin enoftalmi, %79,6'sında koronal planda çekilen bilgisayarlı tomografi görüntülerinin etkili olduğu görüldü. Hastaların %36,7'si ilk 16 saat içinde %10,2'si en geç 72-96 saat için-de ameliyat edildi. Orbita taban onarımı için ultra ince poröz polyetilen kullanıldı. Bu çalışma nedeniyle kendilerine ulaşılan 12 hastanın enoftalmi-egzoftalmi açısından normal sınırlarda olduğu, hiçbir hastada ektropiyon ya da skleral show bulgusu olmadığı, hastaların skara bağlı herhangi bir şikayetlerinin olmadığı görüldü. SONUÇTedavi edilmediğinde enoftalmi ve çift görme ile sonuç-lanabilecek olan orbita taban kırığında, iyi prognoz doğru cerrahi endikasyon, erken cerrahi girişim ve uygun materyal ile onarıma bağlı olduğunu düşünmekteyiz.Anahtar Sözcükler: Bilgisayarlı tomografi; orbita kırıkları; orbita implantları; X-ışınları.

show abstract

Effectiveness of a new perforated 0.15 mm poly-p-dioxanon-foil versus titanium-dynamic mesh in reconstruction of the orbital floor

Cited by 65 publications

References 16 publications

Comparative in vitro study of the proliferation and growth of human osteoblast‐like cells on various biomaterials

Comparative in vitro study of the proliferation and growth of human osteoblast‐like cells on various biomaterials

In vivo efficacy of bone‐marrow‐coated polycaprolactone scaffolds for the reconstruction of orbital defects in the pig

Clinical management and reconstruction of isolated orbital floor fractures: The role of computed tomography during preoperative evaluation

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