Effectiveness of a mass hepatitis A vaccination program in preadolescents

Domı́nguez, Àngela; Salleras, L.; Carmona, Glòria; Batalla, J.

doi:10.1016/s0264-410x(02)00583-2

Cited by 80 publications

(36 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The decrease in hepatitis A incidence we observed involved all age groups, including those not covered by the vaccination program. This fi nding may indicate strong herd immunity, which would confi rm what has been observed in other countries (7)(8)(9). However, there is uncertainty in interpreting current epidemiologic data.…”

supporting

confidence: 70%

“…In our patient, Rickettsia's pathogenic role was demonstrated by PCR, a technique that has previously enabled us to identify other arthropod-borne Rickettsia species (8,9). This case suggests that R. sibirica mongolitimonae infection should be considered in the differential diagnosis of rickettsiosis and tick-bite febrile patients in Spain and confi rms the distribution of this rickettsia in southern Europe.…”

Section: Human Rickettsia Sibirica Mongolitimonae Infection Spainsupporting

confidence: 53%

See 1 more Smart Citation

Control of Hepatitis A by Universal Vaccination of Adolescents, Puglia, Italy

Lopalco

Prato

Chironna

et al. 2008

Emerg. Infect. Dis.

View full text Add to dashboard Cite

show abstract

supporting

confidence: 70%

Section: Human Rickettsia Sibirica Mongolitimonae Infection Spainsupporting

confidence: 53%

Control of Hepatitis A by Universal Vaccination of Adolescents, Puglia, Italy

Lopalco

Prato

Chironna

et al. 2008

Emerg. Infect. Dis.

View full text Add to dashboard Cite

show abstract

“…Vaccination of programs focusing on adolescents in Catalonia have demonstrated efficiency in reducing the prevalence among all age groups under 60 years of age 8 . It has also been said that HAV could disappear from isolated communities through small improvements in sanitation and vaccination for susceptible individuals 10 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of hepatitis A virus infection: the paradoxical example of isolated communities in the western Brazilian Amazon region

Braga

Borges

Júnior

et al. 2009

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

This study evaluated the prevalence of hepatitis A virus infection in the rural area of Lábrea, in the western Brazilian Amazon region. Communities and households were selected randomly. Serum samples were analyzed by means of the immunoenzymatic method for the presence of total antibodies against HAV. The study included 1,499 individuals. The prevalence of anti-HAV was 74.6% (95% CI 72.3-76.8). Univariate analysis showed associations with age (chi-square for linear trend = 496.003, p < 0.001), presence of outside toilet (p < 0.001), history of hepatitis (p < 0.001) and family history of hepatitis (p = 0.05). After adjusting for age, HAV infection also showed an association with the number of people in the family (p = 0.03). The overall prevalence rates were high, but not more than 60% of the children under the age of ten years had already been infected. Very high prevalence was detected only within older cohorts, thus paradoxically defining this as a region with intermediate endemicity, even under the conditions of poverty encountered. Key-words:Hepatitis A virus. Epidemiology. Prevalence. Amazon region. Brazil. RESUMOEste estudo avaliou a prevalência de infecção pelo vírus da hepatite A na área rural de Lábrea, Amazônia Ocidental Brasileira. Comunidades e domicílios foram selecionados aleatoriamente. Amostras de soro foram analisadas pelo método imunoenzimático para os anticorpos totais contra o vírus da hepatite A. O estudo incluiu 1.499 indivíduos. A prevalência do anti-HAV foi 74,6% (IC 95% 72,3 a 76,8). Análise univariada mostrou associação com idade (qui-quadrado de tendência linear = 496,003, p<0,001), presença de sanitário fora do domicílio (p<0,001), passado de hepatite (p<0,001) e história familiar de hepatite (p=0,05). Depois de controlado por idade, a infecção pelo VHA mostrou também associação com o número de pessoas na família (p=0,03). A prevalência global mostra taxas elevadas, entretanto não mais do que 60% dos menores de 10 anos, já são infectados, e prevalências elevadas são detectadas em coortes de mais idade, mostrando paradoxalmente uma definição de região de endemicidade intermediária, mesmo nas condições de pobreza encontradas. Palavras-chaves:Vírus da hepatite A. Epidemiologia. Prevalência. Região amazônica. Brasil.

show abstract

“…14,15 At the lowest end, hepatitis B vaccination costs of US college freshmen were estimated at $41 per dose administered. 12 Routine adolescent vaccination against hepatitis B was consistently found to be costbeneficial from the societal perspective; benefit/cost ratios ranged from $1.14 12 to $1.08 15 [18][19][20] of vaccinating children and adolescents with hepatitis vaccines, the available literature did not consider the economic benefits of indirect protection, although a few pointed to achieving high coverage rates as a main condition; and (2) vaccinating young children is reported as a more effective and cost-effective strategy than vaccinating adolescents or college students.…”

Section: Hepatitis Vaccinesmentioning

confidence: 99%