Effectiveness of a hydroxynaphthoquinone fraction fromArnebia euchromain rats with experimental colitis

Abstract

These findings suggest that HM possesses favourable therapeutic action in TNBS-induced colitis, which provides direct pharmacological evidence for its clinical application.

Differential relieving effects of shikonin and its derivatives on inflammation and mucosal barrier damage caused by ulcerative colitis

“…The anti-inflammatory effects of natural naphthoquinones have been extensively investigated. For instance, Fan et al (2013) investigated the effectiveness of hydroxynaphthoquinone mixture (HM) isolated from A. euchroma in rats with experimental colitis induced by 2, 4, 6-tri-nitrobenzene sulfonic acid (TNBS) in 2013. Their results suggested that HM can remarkably attenuate the clinical and histopathological severity of the TNBS-induced colitis in a dose-dependent manner.…”

“…Small sections of colonic tissue were fixed in 10% buffered formalin and embedded in paraffin. Thereafter, the sections were stained with haematoxylin and eosin (H&E) and the colonic mucosa was histologically evaluated by a pathologist in a blinded fashion, which was widely used as evaluation criterion ( Fan et al, 2013 ).…”

“…Lithospermum erythrorhizon ( L. erythrorhizon ) is a commonly used TCM in the Chinese pharmacopoeia of the People’s Republic of China and is typically abundant in shikonin (SK) derivatives, which have anti-tumor, anti-virus, and anti-inflammatory activities ( Chen et al, 2019 ; Yoshida et al, 2017 ). For example, Fan et al (2013) reported that the crude extract of Arnebia euchroma is effective on rats with experimental colitis. Dozens of species of SK are available in the Boraginaceae plants, among which the representative ones are SK, β, β-dimethylacryl-SK (β,β-dimethylacryl-SK), acetyl-SK (acetyl-SK), 5,8-dihydroxy-1, 4-naphthoquinone (naphthoquinone), and alkanin (AK, the enantiomeric of SK) with high contents ( Papageorgiou et al, 2006 ).…”

Arnebia euchroma ointment can reduce abdominal fat thickness and abdominal circumference of overweight women: A randomized controlled study

“…Hydroxynaphthoquinones (alkannin and shikonin) are the active components of this traditional medicine that have anti-inflammatory, anti-bacterial, anti-fungal, and immune-modulatory roles. [101112] AE was a safe medication used to improve wound healing in burn victims in some studies. [10] The histologic evaluation of the wounds of the rats treated by AE ointment showed that it has improving effects on blood vessels and their density, fibroblast formation, granulation tissue formation, and collagen bundle synthesis.…”

“…[10] The histologic evaluation of the wounds of the rats treated by AE ointment showed that it has improving effects on blood vessels and their density, fibroblast formation, granulation tissue formation, and collagen bundle synthesis. [11] Based on the positive findings of AE, we designed a double-blind single-center clinical trial to investigate the effectiveness of AE ointment on AC and AF.…”