“…Recently, clinical and operational research have indicated that the approaches are more effective when they respond to local socio-cultural characteristics, organization of health service delivery, and type of community activities. These approaches should cover the cascade of actions that include local TB transmission control, screening, and diagnostic investigation of active and latent TB, followed by its antimicrobial treatment, incorporating biomedical approaches [9][10][11][12][13] , biopsychosocial 8,14 , strengthening social protection 15,16 , community participation 17 , and political commitment 18 . However, in high TB burden countries, operational research performed to cover such approaches are limited.…”