Effectiveness of a combined silver nanoparticles/fluoride varnish in dental remineralization in children: in vivo study

Abstract

Dental caries is an infectious disease that can occur in children, sometimes as soon as the teeth eruption starts. Nanotechnology provides effective strategies in prevention and treatment of dental caries. The purpose of this study was to determine the effectiveness of the addition of silver nanoparticles to a fluoride varnish for the remineralization of primary teeth with white spot lesions. A trial was carried out in children with dental demineralization (white spot lesions) on both maxillary dental teeth. One of the teeth received three applications of a fluoride varnish with silver nanoparticles, and the other one, three applications of the same varnish without the silver nanoparticles. We measured the mineral content of the teeth with a laser cavity detection device (DIAGNOdent®) before the first application of the varnishes, and 3 months after the last application. The results show significant differences between teeth treated with silver nanoparticles. Teeth have been treated with fluoride varnish added with silver nanoparticles seemed to enhance dental structure than teeth treated with conventional varnish, and this effect was also found between basal and final measurements in this group. The fluoride varnish added with silver nanoparticles seems to be more effective in the dental remineralization. This strategy may be used as a prophylactic measure to avoid development of caries.

Evaluation of Remineralizing Potential of Nano Silver Fluoride Varnish on Enamel Caries Like Lesions in Primary Teeth

“…Meanwhile, the obtained results revealed that the percent increase in F ion content had significantly occured in NSSF group after intervention in comparison to other remineralizing groups. This may be because of the synergistic effect of nanosilver particles to fluoride, thus enhancing remineralization of early carious lesions (30). The results of the present study are in accordance with Silva et al (31) who concluded that both NSF fluoride and NaF varnish were effective in remineralizing primary teeth enamel through Optical Coherence Tomography (OCT).…”

The Anticariogenic Efficacy of Nano Silver Fluoride

“…Another study conducted in 130 decayed deciduous teeth of children treated with NSF and control (water), 81% of teeth in the NSF group had halted carious lesions on day 7, 72.7% after 5 months and 66.7% of lesions were still arrested after a year, whereas the control group had 0%, 27.4% and 34.7% respectively (dos . In yet another study conducted in 22 children aged 1-6 years with white spot lesions detected by baseline DIAGNOdent values were treated with the fluoride plus 0.1% AgNPs and the children in control group were treated with commercial fluoride varnish once a week for a 3 weeks and after 3 months follow-up DIAGNOdent measurements were taken and it was found that teeth coated with AgNPs varnish exhibited lower mean fluorescence intensity than those treated generic varnish, indicating that dental remineralization was higher in this group (Butrón-Téllez Girón et al, 2017). Tirupathi et al tested the therapeutic caries arresting potency of a prepared 5% silver nanoparticles introduced Sodium fluoride (NSF) varnish with commercially available thirty eight percent SDF in 159 primary molars in 50 children for a year and showed similar number of active and arrested caries.…”

Self-assembling peptide and nano-silver fluoride in remineralizing early enamel carious lesions: Randomized Controlled Clinical Trial

“…Nano-silver uoride (NSF) varnishes have been developed with high remineralization property and antimicrobial effect (3) . Primary teeth treated with uoride varnish with silver nano-particles have improved dental structure than those treated with conventional varnish following remineralization of early WSLs (4) . Nano-silver mouthwash has been proved to be more effective than NaF mouthwash in reducing WSLs in permenant teeth after six months follow-up (5) .…”