Effectiveness of a combination of platelet‐rich plasma, bovine porous bone mineral and guided tissue regeneration in the treatment of mandibular grade II molar furcations in humans

Lekovic, Vojislav; Camargo, Paulo M.; Weinlaender, Michael; Vasilić, Nikola; Aleksić, Zoran; Kenney, E. Barrie

doi:10.1034/j.1600-051x.2003.00368.x

Cited by 133 publications

(141 citation statements)

References 23 publications

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“…ABBM is an extensively researched material which has been successfully used alone for treatment of intra-bony and furcation defects, with a positive role in reducing PD, promoting CAL gain and enhancing defect fill in periodontal defects. 3,4,5,32 The positive results of the control group (ABBM alone) are in accordance with findings from previous studies which had failed to show significant differences between treatment with ABBM alone or combinations of ABBM with enamel matrix derivative or platelet-rich plasma (PRP). 30,39 Although the results of this study suggest that treatment with ABBM-PRF may not have provided significantly better results than those obtained with ABBM alone, the possibility for PRF to show any beneficial effects over the control group might have been masked by the fact that treatment with ABBM alone resulted in significant improvement.…”

supporting

confidence: 80%

“…3,4 Considering its aforementioned properties, ABBM has been successfully used in regenerative treatment of intra-bony and furcation defects. 1,5 In recent years, researchers have focused on biological mediators which have the ability to enhance wound healing and improve clinical benefits of bone replacement grafts. 6 Polypeptide growth factors are biological mediators which regulate cell proliferation, chemotaxis and differentiation and induce periodontal regeneration.…”

Section: Introductionmentioning

confidence: 99%

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Effects of platelet-rich fibrin on healing of intra-bony defects treated with anorganic bovine bone mineral

et al. 2017

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Anorganic bovine bone mineral (ABBM) is extensively used in the treatment of intra-bony defects. Platelet-rich fibrin (PRF) is a new-generation platelet concentrate with a simplified technique. Although certain studies have reported the use of PRF in the treatment of intra-bony defects, to date, none of them have evaluated its additive effects with ABBM. Therefore, a randomised, split-mouth clinical trial was conducted to compare healing of intra-bony defects treated with an ABBM-PRF combination with healing of those treated with ABBM alone. By using a split-mouth design, 15 paired intra-bony defects were randomly treated with either ABBM alone (control group) or ABBM-PRF combination (test group). Following clinical parameters and radiographical measurements were recorded at baseline and 6 months after treatment: plaque index (PI), gingival index (GI), probing depth (PD), gingival recession (GR), clinical attachment level (CAL), vertical bone loss, depth of defect and defect angle. Preoperative clinical and radiographical measurements were similar for the test and control groups. Statistically significant reductions in GI, PD, CAL, vertical bone loss, depth of intra-bony defect and widening of defect angle were detected after treatment in both groups. With respect to inter-group analysis, gain in CAL was significantly greater in the test group than in the control group, whereas no inter-group differences were observed in any other parameter. The results of this study indicate that both therapies are effective in the treatment of intra-bony defects.

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supporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Effects of platelet-rich fibrin on healing of intra-bony defects treated with anorganic bovine bone mineral

et al. 2017

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“…Many studies have been conducted on the clinical effect of platelet-rich plasma on bone regeneration and periodontal regeneration [20,21], but the application of PRP in cartilage repair is relatively new and no published studies have investigated its use in the treatment of TMJ degenerative disease.…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Platelets Rich Plasma Injection in the Superior Joint Space of the Tempromandibular Joint Guided by Ultra Sound in Patients with Non-reducing Disk Displacement

Al-Delayme

Alnuamy

Hamid

et al. 2016

J. Maxillofac. Oral Surg.

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Objective The objective of this study was to determine average improvement during the rest and active mouth opening after ultrasound guided platelets rich plasma injection in the tempromandibular superior joint space for the patients complaining from non-reducing disk displacement. Patients and Methods Thirty-four patients with non-reducing disk displacement underwent guided ultrasound injection of platelet rich plasma to the upper joint space. The extent of maximal mouth opening, chewing efficiency, sound intensity of the TMJ, and tenderness of the TMJ and the masticatory muscles at rest, motion and mastication were thoroughly assessed at the beginning of the study and scheduled for next follow-up at 1st, 3rd, and 6th months. Results Injection with platelets rich plasma was significantly more effective in improvements of the extent of maximal mouth opening, statistics result demonstrated a significant reduction in the VAS values of pain at rest, motion and mastication compared to the baseline VAS values. Conclusion PRP injection to the upper temporomandibular joint space provided improvement in signs and symptoms of patient with non-reducing disk displacement of the temporomandibular joint.

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“…The interaction between these bioactive proteins and receptors has a key role in the process of wound healing 7,8 . PRP is used in the treatment of chronic cutaneous and soft tissue ulcerations and especially in periodontal and oral surgery, maxillofacial surgery, orthopedic and traumatic surgery, cosmetic and plastic surgery, spinal surgery, heart by-pass surgery, and in burns [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] . The purpose of our study was to examine the histopathological effects of topical PRP and PPP treatments in wound healing on rats with partial thickness wounds.…”

Section: Introductionmentioning

confidence: 99%

Is there any association between mycosis fungoides and Th-1, Th-2 cytokines and transforming growth factor-beta 1 gene polymorphisms?

Yazıcı¹,

Aydoğan²,

Sarıcaoğlu³

et al. 2018

TURKDERM

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Effectiveness of a combination of platelet‐rich plasma, bovine porous bone mineral and guided tissue regeneration in the treatment of mandibular grade II molar furcations in humans

Abstract: It was concluded that the PRP/BPBM/GTR combined technique is an effective modality of regenerative treatment for mandibular grade II furcation defects. Further studies are necessary to elucidate the role played by each component of the combined therapy in achieving these results.

Cited by 133 publications

References 23 publications

Effects of platelet-rich fibrin on healing of intra-bony defects treated with anorganic bovine bone mineral

Effects of platelet-rich fibrin on healing of intra-bony defects treated with anorganic bovine bone mineral

The Efficacy of Platelets Rich Plasma Injection in the Superior Joint Space of the Tempromandibular Joint Guided by Ultra Sound in Patients with Non-reducing Disk Displacement

Is there any association between mycosis fungoides and Th-1, Th-2 cytokines and transforming growth factor-beta 1 gene polymorphisms?

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