Effectiveness of 1- and 2- per cent acetic acid solutions in the 2-week treatment of granular myringitis

Abstract

Background: Granular myringitis is characterized by de-epithelization of the tympanic membrane. Patients present with intermittent otorrhea, otalgia or itching. Granular myringitis could result in ear canal stenosis from fibrotic formation if improper or inadequate treatments were offered. At the present, there are still no standard specific topical ear drops for granular myringitis. The choices of treatment are various with inconsistent success rate in variable timeline.�Objectives: �To compare granular myringitis treatment between 1% and 2% acetic acid solution at 2 weeks
 Materials and methods: This study is a double blind randomized controlled trial to compare the effectiveness of 1% acetic acid solution and 2% acetic acid solution on 2 week-period treatment for granular myringitis. There were 47 participants in this study. They were enrolled and randomly allocated into two groups between October 2021 and June 2022. Results: The success rates at 2 week-period of treatment between 2 groups were not statistically significant. All patients can tolerate diluted vinegar. Recurrent rate at 8 weeks after completed treatment was 10%. Conclusions: Data from this study cannot show the difference between 1% and 2% diluted vinegar in granular myringitis treatment within 2 weeks.