Effectiveness in the Removal of Endotoxins and Microbiological Profile in Primary Endodontic Infections Using 3 Different Instrumentation Systems: A Randomized Clinical Study

Abstract

Signs and symptoms were correlated with microorganisms. Endodontic treatment was effective in reducing bacteria and endotoxins but was not capable of completely removing them from the root canal.

Effect of instrumentation systems on endotoxin reduction from root canal systems: A systematic review of clinical studies and meta‐analysis

“…After screening titles and abstracts, 20 articles were included for review of the full text. One study evaluated endotoxin reduction after root canal instrumentation in root canal retreatment (19), while two studies evaluated the same after root canal instrumentation in root canal treatment (20,21). Three articles were included for further analysis to inform this review.…”

“…Seventeen papers were excluded as they did not meet the inclusion criteria. The sample size ranged from 30 (19,21) to 48 (20). The Kappa value of inter-reader agreement was 0.80 (substantial agreement).…”

“…Of the two studies involving root canal treatment, one study (20) (19)(20)(21) showed a significant reduction in endotoxin following treatment with rotary and reciprocating instruments. However, all studies reported no significant differences between the instrument groups in endotoxin reduction.…”

“…The three studies presented their skewed data as median value. 3), and one (21) was excluded because of insufficient data (the authors were contacted thrice via e-mail in an attempt to obtain data). The lack of blinding the investigators was apparent (Appendix 1).…”

“…All studies performed the sample collection from single rooted teeth (19)(20)(21). The study designs were standardised, but the sample sizes were considered as moderately sufficient, which probably was the reason for skewness of the data presented.…”