Effectiveness and tolerability of a squalane and dimethicone-based treatment for head lice

Abstract

Head lice (Pediculus humanus capitis) are worldwide obligate human ectoparasites, with high implications in pediatrics. In Europe, first-line topical neurotoxic insecticidal therapeutic strategies are being replaced by topical physically acting agents as the first-choice treatment. Safety of the active ingredients and high efficacy in a one-time single-dose treatment with a brief treatment application time are key issues for consumer use and effective compliance. The aim of this study was to assess the in vitro efficacy of a newly developed squalane and dimethicone-based pediculicidal formula, against motile head lice and eggs after 2 and 5 min immersion in the product, as well as its skin tolerance and acceptability under dermatological and pediatric expert control in children with atopic skin. The results indicate that at both time points, 100% mortality rate of head lice crawling stages and late-stage eggs was achieved. The formula was well tolerated and suitable for children with atopic skin from 12 months of age. Showing high in vitro efficacy and good skin acceptability, this solution is presented as a new safe alternative therapy for treatment of head lice infestations.

Pediculosis and Factors Affecting its Prevalence among Schoolchildren in Amol City, Northern Iran

“…The prevalence of pediculosis has been reported to be growing worldwide since the mid-1960s reaching up to 80% in some countries (9). However, based on epidemiological studies, the average prevalence rate of pediculosis in schools in different countries was stated to be 16%.…”

“…As an illness, pediculosis comes second after the common cold among schoolchildren worldwide with infection rates ranging between 5% in Europe and 33% in South America (7,8). In Iran, head louse infestation is a common health problem, although, the prevalence of pediculosis varies in different regions from 0.9 to 20.5% (9)(10)(11)(12). Studies have shown that public centers such as barracks, dormitories, educational centers, and communities are the most infected locations in Iran (1).…”

The Art and Science of Cosmetics: Understanding the Ingredients

“…A study in 2021 designed a squalane and dimethicone-based formula for treating head lice. The results indicated that the formula was safe for children with good skin compatibility and acceptability [25].…”

Anatomical and Metabolome Features of Haloxylon aphyllum and Haloxylon persicum Elucidate the Resilience against Gall-Forming Insects

“…Squalene, phytol, and phytol acetate were identified in H. persicum, underscoring a more diverse terpene profile compared to H. aphyllum. The literature supports that both phytol and its derivatives [104][105][106], as well as squalene [107][108][109], exhibit marked insecticidal properties. These terpenes are present in the metabolic spectrum of the control H. persicum but absent in H. aphyllum.…”