Effectiveness and Safety Profile of Alternative Tobacco and Nicotine Products for Smoking Reduction and Cessation: A Systematic Review

Zakiyah, Neily; Purwadi, Febby V; Insani, Widya N.; Abdulah, Rizky; Puspitasari, Irma Melyani; Barliana, Melisa Intan; Lesmana, Ronny; Amaliya, Amaliya; Suwantika, Auliya A.

doi:10.2147/jmdh.s319727

Cited by 10 publications

(11 citation statements)

References 121 publications

(383 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Apart from active smoking, exposure to passive smoking appears to negatively influence disease activity and progression in MS. We replicated previous findings of smoking as a risk factor in MS, and therefore that smoking cessation after diagnosis is an important secondary preventive measure. Snuff use was not associated with higher disease activity or progression, suggesting that nicotine replacement therapy could be a safe way to increase the chance of quitting smoking among patients with MS 23 24…”

Section: Discussionmentioning

confidence: 99%

Influence of oral tobacco versus smoking on multiple sclerosis disease activity and progression

Olsson

Hillert

et al. 2023

J Neurol Neurosurg Psychiatry

View full text Add to dashboard Cite

We aimed to study the influence of smoking habits, exposure to passive smoking and snuff use on disease progression, cognitive performance and quality of life in patients with multiple sclerosis (MS).MethodPatients from two population-based case–control studies were categorised based on tobacco exposure at diagnosis and were followed up to 15 years post diagnosis through the Swedish MS registry (n=9089) regarding changes in Expanded Disability Status Scale (EDSS), Multiple Sclerosis Impact Scale 29 and Symbol Digit Modalities Test. We used linear mixed models to analyse long-term changes, and Cox regression models with 95% CI using 24-week confirmed disability worsening, reaching EDSS 3 and EDSS 4, respectively, physical and psychological worsening and cognitive disability worsening as end points. The influence of smoking cessation post diagnosis was also investigated.ResultsCompared with non-smokers, current smokers had a faster EDSS progression (βcurrent smoking×time=0.03, 95% CI 0.02 to 0.04). A faster EDSS progression was also associated with passive smoking (βcurrent passive smoking×time=0.04, 95% CI 0.03 to 0.06). Smoke exposure negatively impacted all secondary outcomes. Those who continued smoking had worse outcomes than those who stopped smoking post diagnosis. Snuff users had a more favourable EDSS progression, compared with never users.ConclusionsOur findings indicate that both smoking and passive smoking have a negative influence on MS and that smoking cessation post diagnosis may be an important secondary preventive measure. Snuff use was associated with slower disease progression, suggesting that nicotine replacement therapy could be an attractive way to increase the chance of quitting smoking among patients with MS.

show abstract

Section: Discussionmentioning

confidence: 99%

Influence of oral tobacco versus smoking on multiple sclerosis disease activity and progression

Olsson

Hillert

et al. 2023

J Neurol Neurosurg Psychiatry

View full text Add to dashboard Cite

show abstract

“…Increased AEs during the NRT gum test sessions could also result from prolonged withdrawal effects after overnight abstinence. In general, the numbers of AEs reported in clinical research of vapor products such as Vuse Solo are generally low and characterized overall as mostly mild, transient, and expected 61 .…”

Section: Discussionmentioning

confidence: 99%

Part one: abuse liability of Vuse Solo (G2) electronic nicotine delivery system relative to combustible cigarettes and nicotine gum

Campbell

Jin

Round

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Abuse liability (AL) of electronic nicotine delivery systems (ENDS) is relevant as the category increases in popularity as a potentially less-harmful alternative to cigarette smoking. AL assessments are important to the FDA in determining if a new product is appropriate for the protection of public health. This paper reports the results for Vuse Solo (G2 cartridge design) compared to high and low AL-comparators evaluated in an open-label, randomized crossover confinement AL study. The confinement design was adapted from previous ambulatory studies of Vuse Solo (G1 cartridge design) and included product familiarization sessions before each four-hour test session in which subjective measures, nicotine pharmacokinetics (PK), and physiological endpoints were assessed following a single 10-min ad libitum product use session. Product liking, intent to use again, suppression of urge to smoke, and nicotine PK were lower after use of Vuse Solo compared to cigarettes and higher after use of Vuse Solo compared to nicotine gum. No significant differences in blood pressure or heart rate were observed between the products pre- to post-product use. These data reinforce previous research and provide the scientific evidence to support regulatory decisions demonstrating that Vuse Solo has an AL profile lower than that of combustible cigarettes but higher than that of nicotine gum and, therefore, may be a suitable replacement for cigarette smoking for some adult smokers.

show abstract

“…Evidence is unclear if use of EC, also referred to as vaping, are useful in assisting cessation of CS 10 but EC are often initiated to quit CS 11 . However, emerging evidence reports that EC use among current CS increases future smoking initiation among youth, increases the odds of transition to poly-tobacco use (PTU) 12 , 13 among current CS and acts as a gateway to CS among non-smokers 14 , 15 .…”

Section: Introductionmentioning

confidence: 99%

Smoking cessation behaviors and reasons for use of electronic cigarettes and heated tobacco products among Romanian adults

Hussain

Sreeramareddy

2022

Sci Rep

View full text Add to dashboard Cite

We report cessation behaviors, reasons for use of electronic cigarettes (EC) and heated tobacco products (HTP) and association of their use with quit attempts and smoking intensity using Romania Global Adult Tobacco Survey 2018. Weighted estimates of EC and HTP by cigarette smoking (CS) status were assessed. Quit attempts, intention to quit, reasons for lack of intention to quit among current CS, and reasons for current use of EC and HTP were estimated. The association of ‘ever use’ of EC and HTP with cigarette smoking intensity and quit attempts was explored using binary logistic regression. Of the total 4571 surveyed, 1243 (27.3%) were current CS, 300 (24.4%) made quit attempts in the past 12 months. Only 38 (12.5%) and 26 (8.6%) had used EC and HTP as an aid to quit. Among current CS, 512 (41.2%) had no intention to quit. Reasons for this were, ‘enjoy smoking’ (86.1%), ‘reduce stress’ (65.9%), and ‘staying alert’ (46.3%). Awareness and use of EC and HTP were significantly higher among current CS. ‘Dual use’ of EC and HTP with CS was manifolds higher than stand-alone use. Reasons for current use of EC and HTP were ‘enjoyment’, and ‘use in places where smoking was prohibited’.

show abstract

Effectiveness and Safety Profile of Alternative Tobacco and Nicotine Products for Smoking Reduction and Cessation: A Systematic Review

Cited by 10 publications

References 121 publications

Influence of oral tobacco versus smoking on multiple sclerosis disease activity and progression

Influence of oral tobacco versus smoking on multiple sclerosis disease activity and progression

Part one: abuse liability of Vuse Solo (G2) electronic nicotine delivery system relative to combustible cigarettes and nicotine gum

Smoking cessation behaviors and reasons for use of electronic cigarettes and heated tobacco products among Romanian adults

Contact Info

Product

Resources

About