Effectiveness and safety of traditional Chinese medicine in the treatment of steroid-osteonecrosis of femoral head

Background: Hip synovitis is a common hip disorder in children and a frequent cause of hip or groin pain in children. Its onset is rapid and poses a threat to patient health. Conventional treatment methods have suboptimal efficacy and large side effects. Clinical study surface, the therapeutic effect of traditional Chinese medicine (TCM) on hip synovitis in children is obvious. Therefore, we aimed to systematically review the efficacy and safety of TCM on hip synovitis in children.Methods: We will search databases including PubMed, Web of Science, EMBASE database, Cochrane Library, MEDLINE, Wanfang Data, Chinese biomedical literature database, China National Knowledge Infrastructure, Chinese science and technology journals database, and World Health Organization International Clinical Trials Registry Platform (since the databases were established). We also searched secondary resources, including the reference lists of studies. Included articles were carefully screened and reviewed by 2 researchers. Statistical analysis was performed using Review Manager 5.3 software.Results: This study will comprehensively evaluate the efficacy and safety of TCM for the treatment of hip synovitis in children. Conclusion:This systematic review explores the efficacy and safety of TCM for the treatment of hip synovitis in children and provides an update on its clinical use.

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“…We have full registration information available at inpasy.com. Our report will follow the PRISMA recommendations [15] …”

Section: Methodsmentioning

confidence: 99%

Evaluation of efficacy and safety of traditional Chinese medicine in the treatment of hip synovitis in children

Chen

He²,

Liu

et al. 2021

Medicine

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“…[ 7 ] In traditional Chinese medicine, AVNFH is referred to as “bone impediment,” “hip impediment,” and “bone erosion.” The primary treatment for hemorrhagic necrosis is increasing blood circulation and eliminating blood stasis. [ 8 , 9 ] The “Yizong Jinjian Gynecological Heart Method Essentials” published by Wu Qian is when Taohong Siwu decoction (THSWD) was first discovered. It is made up of Carthamus tinctorius L., Prunus persica (L.) Batsch, Paeonia lactiflora Pall, Rehmannia glutinosa (Gaertn.)…”

Section: Introductionmentioning

confidence: 99%

Exploring the potential mechanism of Taohong Siwu decoction in the treatment of avascular necrosis of the femoral head based on network pharmacology and molecular docking

Chen,

Song,

Qiu

et al. 2023

Medicine

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Based on network pharmacology and molecular docking, this study seeks to investigate the mechanism of Taohong Siwu decoction (THSWD) in the treatment of avascular necrosis of the femoral head (AVNFH). The Traditional Chinese Medicine Systems Pharmacology database was used in this investigation to obtain the active ingredients and related targets for each pharmaceutical constituent in THSWD. To find disease-related targets, the terms “avascular necrosis of the femoral head,” “necrosis of the femoral head,” “steroid-induced necrosis of the femoral head,” “osteonecrosis,” and “avascular necrosis of the bone” were searched in the databases DisGeNET, GeneCards, Comparative Toxicogenomics Database, and MalaCards. Following the identification of the overlap targets of THSWD and AVNFH, enrichment analysis using gene ontology, Kyoto Encyclopedia of Genes and Genomes, Reactome, and WikiPathways was conducted. The “THSWD-drug-active compound-intersection gene-hub gene-AVNFH” network and protein-protein interaction network were built using Cytoscape 3.9.1 and string, and CytoHubba was used to screen hub genes. The binding activities of hub gene targets and key components were confirmed by molecular docking. 152 prospective therapeutic gene targets were found in the bioinformatics study of ONFH treated with THSWD, including 38 major gene targets and 10 hub gene targets. The enrichment analysis of 38 key therapeutic targets showed that the biological process of gene ontology analysis mainly involved cytokine-mediated signaling pathway, angiogenesis, cellular response to reactive oxygen species, death-inducing signaling complex. The Kyoto Encyclopedia of Genes and Genomes signaling pathway mainly involves TNF signaling pathway, IL-17 signaling pathway, and the Recactome pathway mainly involves Signaling by Interleukins, Apoptosis, and Intrinsic Pathway for Apoptosis. WikiPathways signaling pathway mainly involves TNF-related weak inducer of apoptosis signaling pathway, IL-18 signaling pathway. According to the findings of enrichment analysis, THSWD cured AVNFH by regulating angiogenesis, cellular hypoxia, inflammation, senescence, apoptosis, cytokines, and cellular proliferation through the aforementioned targets and signaling pathways. The primary component of THSWD exhibits a strong binding force with the key protein of AVNFH. This study sheds new light on the biological mechanism of THSWD in treating AVNFH by revealing the multi-component, multi-target, and multi-pathway features and molecular docking mechanism of THSWD.

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“…Traditional Chinese medicine (TCM) has been widely used in the treatment of orthopedic diseases (such as SANFH, osteoporosis, KOA, and gout) in Japan, Korea, China, and other Asian countries and regions. It is gradually accepted in clinical applications and medical institutes worldwide [ 7 – 10 ]. Numerous basic and clinical experiments show that compound TCM is economical and has multiplicity and low side effects in treating SANFH [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…It is gradually accepted in clinical applications and medical institutes worldwide [ 7 – 10 ]. Numerous basic and clinical experiments show that compound TCM is economical and has multiplicity and low side effects in treating SANFH [ 10 , 11 ]. Gujiansan is a formula created by Professor Wei Guikang, a master of TCM, based on the theory of traditional Chinese therapeutics and medication as well as his accumulated experience in the past decades.…”

Section: Introductionmentioning

confidence: 99%

Network-Based Pharmacology and Bioinformatics Study on the Mechanism of Action of Gujiansan in the Treatment of Steroid-Induced Avascular Necrosis of the Femoral Head

Ren

Wen

Han

et al. 2022

BioMed Research International

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Objective. To investigate the main pharmacological basis and mechanism of action of Gujiansan in the treatment of steroid-induced avascular necrosis of the femoral head (SANFH). Methods. The active constituents and targets of Gujiansan were screened by using TCMSP and other databases, and relevant disease targets were obtained by analyzing the microarray of SANFH in the GEO database. The intersection of the two was taken to obtain the potential targets of Gujiansan for the treatment of SANFH, and key active constituents were screened with the “active constituent-target” network constructed by the Cytoscape software; then, the STRING database was used to construct the protein interaction network to screen the key targets. The Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses of key targets were performed by the DAVID database, and the relationship between the “key active constituent-key target-key signaling pathway” was explored. Finally, the molecular docking between key active constituents and key targets was verified. In addition, qPCR detection technology was used to evaluate the preventive and therapeutic effects of key active constituents of Gujiansan in a rat osteoblast model of SANFH to verify the possible mechanism of the effect of Gujiansan in the treatment of SANFH. Results. (1) 106 active constituents and 55 targets were obtained for the treatment of SANFH. (2) Quercetin, luteolin, kaempferol, cryptotanshinone, and naringenin were the key active constituents for the treatment of SANFH. (3) IL1B, STAT3, CAT, PTGS2, and MAPK3 were the key targets for the treatment of SANFH. (4) IL1B, STAT3, CAT, PTGS2, MAPK3, and HMOX1 are key targets in the protein interaction network. (5) DAVID enrichment analysis mainly covers the regulation of DNA-binding transcription factor activity, positive regulation of cytokine production, and response to oxidative stress and other biological processes, involving IL-17, AGE-RAGE, C-type lectin receptor, and other signaling pathways. (6) Gujiansan is a multitarget and multisignaling pathway for the treatment of SANFH. (7) Good binding activity exists between key active constituents and key targets. Conclusion. This study analyzes the potential mechanism of action of Gujiansan in the treatment of SANFH with network pharmacology, which can provide a reference for the further study of its pharmacological basis and targets.

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Effectiveness and safety of traditional Chinese medicine in the treatment of steroid-osteonecrosis of femoral head

Cited by 7 publications

References 25 publications

Evaluation of efficacy and safety of traditional Chinese medicine in the treatment of hip synovitis in children

Evaluation of efficacy and safety of traditional Chinese medicine in the treatment of hip synovitis in children

Exploring the potential mechanism of Taohong Siwu decoction in the treatment of avascular necrosis of the femoral head based on network pharmacology and molecular docking

Network-Based Pharmacology and Bioinformatics Study on the Mechanism of Action of Gujiansan in the Treatment of Steroid-Induced Avascular Necrosis of the Femoral Head

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