Effectiveness and safety of Tai Chi for chronic pain of knee osteoarthritis

Guo, Guangxin; Wu, Boyi; Xie, Shengji; Xu, Jianghan; Zhou, Xu; Wu, Guanghui; Lu, Ping

doi:10.1097/md.0000000000028497

Cited by 2 publications

(2 citation statements)

References 32 publications

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“…Based on the “Guidelines for the Diagnosis and Treatment of Osteoarthritis (2018 Edition)” formulated by the Joint Surgery Group of the Orthopaedic Branch of the Chinese Medical Association, the diagnostic criteria for KOA were formulated: ① signs include joint pain, swelling, stiffness, deformity, a sense of snapping or friction, limited joint movement, and difficulty in walking or squatting [ 7 ]; ② recurrent joint pain within 1 month; ③ knee X-ray examination showed asymmetric joint space narrowing, subchondral bone sclerosis or cystic lesions, and osteophyte formation at the joint edge; and ④ magnetic resonance examination showed the thickness of knee articular cartilage thinning, defect, bone marrow edema, cystic changes, and some joint effusion or popliteal cyst.…”

Section: Methodsmentioning

confidence: 99%

[Retracted] Effects of Modified Duhuo Jisheng Decoction Combined with Arthroscopic Surgery on Bone Metabolism, Oxidative Stress, and Serum TLR4 and TGF‐β1 in Patients with Knee Osteoarthritis

Zeng

Lin

2022

Journal of Environmental and Public Health

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Objective. To analyze the effects of modified Duhuo Jisheng Decoction combined with arthroscopic surgery on bone metabolism, oxidative stress, and serum TLR4 and TGF-β1 in patients with knee osteoarthritis (KOA). Methods. Prospectively select 82 patients with KOA from January 2020 to January 2022 in our hospital and divide them into the control group and observation group according to the random number table method, with 41 patients in each group. The control group was treated with arthroscopic surgery alone and routine anti-infection after operation. The observation group was treated with Duhuo Jisheng Decoction on the basis of the treatment of the control group. The patients in the two groups were treated continuously for 4 weeks. The improvement of patients’ symptoms was evaluated by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Before treatment and 4 weeks after treatment, the scores of traditional Chinese medicine (TCM) symptoms, bone metabolism indicators (cartilage oligomeric matrix protein (COMP), collagen type II carboxy terminal peptide (ctx-II), and matrix metalloproteinase-3 (MMP-3)), oxidative stress indicators (superoxide dismutase (SOD), glutathione peroxidase (GSHPx), malondialdehyde (MDA), nitric oxide (NO)), serum Toll-like receptor 4 (TLR4), and transforming growth factor β (TGF-β) level were compared between the two groups. Results. After treatment, the WOMAC score of the two groups decreased ( 42.45 ± 10.83 ) in the observation group and ( 67.81 ± 14.63 ) in the control group. The WOMAC score of the observation group was lower than that of the control group ( P < 0.05 ). After treatment, the levels of COMP, CTX-II, and MMP-3 in the two groups decreased, and the levels of COMP, CTX-II, and MMP-3 in the observation group were lower than those in the control group ( P < 0.05 ). After treatment, the levels of SOD and GSHPx increased, while the levels of MDA and NO decreased in the two groups. The levels of SOD and GSHPx in the observation group were higher than those in the control group, while the levels of MDA and NO were lower than those in the control group ( P < 0.05 ). After treatment, the TLR4 level in the observation group was lower than that of the control group, and the level of TGF-β in the observation group was higher than that of the control group ( P < 0.05 ). Conclusion. Compared with arthroscopic surgery alone, combined with modified Duhuo Jisheng Decoction can better alleviate the clinical symptoms of patients with KOA, improve their bone metabolism, oxidative stress indicators, and serum TLR4 and TGF-β 1 level, and reduce the inflammatory injury of knee joint.

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Section: Methodsmentioning

confidence: 99%

[Retracted] Effects of Modified Duhuo Jisheng Decoction Combined with Arthroscopic Surgery on Bone Metabolism, Oxidative Stress, and Serum TLR4 and TGF‐β1 in Patients with Knee Osteoarthritis

Zeng

Lin

2022

Journal of Environmental and Public Health

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“…Tai chi is highly recommended in individuals with knee or hip OA, as it has demonstrated effects on both physical and mental well-being [142]. Similarly, while yoga appears to offer significant benefits to patients, there is a dearth of literature recommending its use [142,144,145].…”

Section: Physical Treatments In Oamentioning

confidence: 99%

Osteoarthritis: Insights into Diagnosis, Pathophysiology, Therapeutic Avenues, and the Potential of Natural Extracts

Coppola,

Greco,

Munir

et al. 2024

CIMB

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Osteoarthritis (OA) stands as a prevalent and progressively debilitating clinical condition globally, impacting joint structures and leading to their gradual deterioration through inflammatory mechanisms. While both non-modifiable and modifiable factors contribute to its onset, numerous aspects of OA pathophysiology remain elusive despite considerable research strides. Presently, diagnosis heavily relies on clinician expertise and meticulous differential diagnosis to exclude other joint-affecting conditions. Therapeutic approaches for OA predominantly focus on patient education for self-management alongside tailored exercise regimens, often complemented by various pharmacological interventions primarily targeting pain alleviation. However, pharmacological treatments typically exhibit short-term efficacy and local and/or systemic side effects, with prosthetic surgery being the ultimate resolution in severe cases. Thus, exploring the potential integration or substitution of conventional drug therapies with natural compounds and extracts emerges as a promising frontier in enhancing OA management. These alternatives offer improved safety profiles and possess the potential to target specific dysregulated pathways implicated in OA pathogenesis, thereby presenting a holistic approach to address the condition’s complexities.

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Effectiveness and safety of Tai Chi for chronic pain of knee osteoarthritis

Cited by 2 publications

References 32 publications

[Retracted] Effects of Modified Duhuo Jisheng Decoction Combined with Arthroscopic Surgery on Bone Metabolism, Oxidative Stress, and Serum TLR4 and TGF‐β1 in Patients with Knee Osteoarthritis

[Retracted] Effects of Modified Duhuo Jisheng Decoction Combined with Arthroscopic Surgery on Bone Metabolism, Oxidative Stress, and Serum TLR4 and TGF‐β1 in Patients with Knee Osteoarthritis

Osteoarthritis: Insights into Diagnosis, Pathophysiology, Therapeutic Avenues, and the Potential of Natural Extracts

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