Effectiveness and Safety of <sup>18</sup>F-FDG PET in the Evaluation of Dementia: A Review of the Recent Literature

Bohnen, Nicolaas I.; Djang, David; Herholz, Karl; Anzai, Yoshimi; Minoshima, Shinsei

doi:10.2967/jnumed.111.096578

Cited by 253 publications

(175 citation statements)

References 90 publications

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“…Ki-67 played no role in 18 F-FDG uptake. 18 F-FDG is an analogue of glucose and uses a similar transport system as glucose (Bohnen et al, 2012). In tumor cells, especially malignant tumor cells from lung cancer (Liao et al, 2012), breast cancer (Groheux et al, 2011) and NHL (Alongi et al, 2014;Singh et al, 2014), 18 F-FDG accumulation rises dramatically.…”

Section: Discussionmentioning

confidence: 99%

Biological correlation between glucose transporters, Ki-67 and 2-deoxy-2-[18F]-fluoro-D-glucose uptake in diffuse large B-cell lymphoma and natural killer/T-cell lymphoma

Liu¹,

Zhai²,

Wu³

2016

Genet. Mol. Res.

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Section: Discussionmentioning

confidence: 99%

Biological correlation between glucose transporters, Ki-67 and 2-deoxy-2-[18F]-fluoro-D-glucose uptake in diffuse large B-cell lymphoma and natural killer/T-cell lymphoma

Liu¹,

Zhai²,

Wu³

2016

Genet. Mol. Res.

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“…Diagnosis of bvFTD remains difficult, with patients being erroneously diagnosed with Alzheimer's disease (AD) or psychiatric disorders 5, 6, 7. A large body of work has demonstrated that brain imaging, in particular structural magnetic resonance imaging (MRI) and functional imaging of cerebral blood flow (CBF) with SPECT or cerebral metabolic rate of glucose (CMRgl) with fluorodeoxyglucose (FDG) positron emission tomography (PET), can improve the accuracy of differential diagnosis in bvFTD 8, 9, 10, 11, 12, 13, 14, 15, 16, 17. These findings led the Center for Medicare and Medicaid Services (CMS) to approve FDG‐PET as a diagnostic test for differentiating bvFTD from AD (https://www.cms.gov/medicare-coverage-database/details/ncd-details.aspx?NCDId=288&ncdver=3&bc=BAABAAAAAAAA&).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic utility of ASL‐MRI and FDG‐PET in the behavioral variant of FTD and AD

Tosun

Schuff

Rabinovici

et al. 2016

Ann Clin Transl Neurol

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ObjectiveTo compare the values of arterial spin‐labeled (ASL) MRI and fluorodeoxyglucose (FDG) PET in the diagnosis of behavioral variant of frontotemporal dementia (bvFTD) and Alzheimer's disease (AD).MethodsPartial least squares logistic regression was used to identify voxels with diagnostic value in cerebral blood flow (CBF) and cerebral metabolic rate of glucose (CMRgl) maps from patients with bvFTD (n = 32) and AD (n = 28), who were compared with each other and with cognitively normal controls (CN, n = 15). Diagnostic values of these maps were compared with each other.ResultsRegions that differentiated each disorder from controls were similar for CBF and CMRgl. For differentiating AD from CN, the areas under the curve (AUC) for CBF (0.89) and CMRgl (0.91) were similar, with similar sensitivity (CBF: 86%, CMRgl: 78%) and specificity (CBF: 92%, CMRgl: 100%). Likewise, for differentiating bvFTD from CN performances of CBF (AUC = 0.83) and CMRgl (AUC = 0.85) were equivalent, with similar sensitivity (CBF: 78%, CMRgl: 79%) and specificity (CBF: 92%, CMRgl: 100%). In differentiating bvFTD from AD, classification was again similar for CBF (AUC = 0.87) and CMRgl (AUC = 0.79), as were sensitivity (CBF: 83%, CMRgl: 89%) and specificity (CBF: 93%, CMRgl: 78%). None of the differences in any performance measure were statistically significant.InterpretationASL‐MRI has similar diagnostic utility as FDG‐PET in the diagnosis of AD and bvFTD. Continued development of ASL‐MRI as a diagnostic tool for neurodegenerative dementias is warranted.

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“…2 In contrast, positron emission tomography with [ 18 F]-fluorodeoxyglucose (FDG-PET) is an established clinical tool, assisting early and differential diagnosis of dementing and movement disorders. [3][4][5] These conditions are accompanied by a certain spatial pattern of neural degeneration that is captured by PET as regional glucose hypometabolism. So far, however, this imaging tool has got little attention in studies of healthy cognitive function and non-degenerative brain diseases.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Connectivity as Index of Verbal Working Memory

Zou

Chételat

Baydoğan

et al. 2015

J Cereb Blood Flow Metab

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Positron emission tomography (PET) data are commonly analyzed in terms of regional intensity, while covariant information is not taken into account. Here, we searched for network correlates of healthy cognitive function in resting state PET data. PET with [18 F]-fluorodeoxyglucose and a test of verbal working memory (WM) were administered to 35 young healthy adults. Metabolic connectivity was modeled at a group level using sparse inverse covariance estimation. Among 13 WM-relevant Brodmann areas (BAs), 6 appeared to be robustly connected. Connectivity within this network was significantly stronger in subjects with above-median WM performance. In respect to regional intensity, i.e., metabolism, no difference between groups was found. The results encourage examination of covariant patterns in FDG-PET data from non-neurodegenerative populations.

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Effectiveness and Safety of ¹⁸F-FDG PET in the Evaluation of Dementia: A Review of the Recent Literature

Cited by 253 publications

References 90 publications

Biological correlation between glucose transporters, Ki-67 and 2-deoxy-2-[18F]-fluoro-D-glucose uptake in diffuse large B-cell lymphoma and natural killer/T-cell lymphoma

Biological correlation between glucose transporters, Ki-67 and 2-deoxy-2-[18F]-fluoro-D-glucose uptake in diffuse large B-cell lymphoma and natural killer/T-cell lymphoma

Diagnostic utility of ASL‐MRI and FDG‐PET in the behavioral variant of FTD and AD

Metabolic Connectivity as Index of Verbal Working Memory

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Effectiveness and Safety of 18F-FDG PET in the Evaluation of Dementia: A Review of the Recent Literature

Cited by 253 publications

References 90 publications

Biological correlation between glucose transporters, Ki-67 and 2-deoxy-2-[18F]-fluoro-D-glucose uptake in diffuse large B-cell lymphoma and natural killer/T-cell lymphoma

Biological correlation between glucose transporters, Ki-67 and 2-deoxy-2-[18F]-fluoro-D-glucose uptake in diffuse large B-cell lymphoma and natural killer/T-cell lymphoma

Diagnostic utility of ASL‐MRI and FDG‐PET in the behavioral variant of FTD and AD

Metabolic Connectivity as Index of Verbal Working Memory

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Product

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Effectiveness and Safety of ¹⁸F-FDG PET in the Evaluation of Dementia: A Review of the Recent Literature