Effectiveness and safety of new oral and injectable agents for in-hospital management of type 2 diabetes in general wards: Systematic review and meta-analysis

Soto-Chávez, María Juliana; Muñoz-Velandia, Óscar Mauricio; Alzate, Juan Pablo; Lombo, Carlos Ernesto; Carrillo, Diana Cristina Henao; Medina, Ana María

doi:10.1016/j.diabres.2022.110019

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…Diabetes hyperglycemia is thought to cause immune response dysfunction, which fails to control the spread of invading pathogens in diabetic subjects. As a result, diabetic patients are known to be more susceptible to infections ((AL-Sahi, AL-Hasnawi and Ali, no date), (Soto-Chávez et al, 2022)). The most commonly encountered micro-vascular complication of diabetes is diabetic neuropathy, with a prevalence of 50-60%; neuropathy may cause decreased nerve functions and nerve blood perfusion with persistent nerve damage.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Immunological Levels of IL-37, IL-38, and IL-17A in Iraqi Patients with Diabetic Foot Ulcers

AL-Sahi,

AL-Hasnawi,

Ali

2024

Journal-Pharmacy

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t Diabetes mellitus, a significant cause of mortality around the globe, can result in several secondary complications, including diabetic foot syndrome, which is brought on by diabetic neuropathy and ischemia. Approximately 15% of diabetic patients suffer from diabetic foot complications, which results in high rates of morbidity and mortality of people with Diabetes mellitus. The study's objective is to measure serum levels of IL-37, IL-38 & IL-17A in diabetic mellitus (type 1 & 2) patients with and without diabetic foot ulcer complications and in the control group as well as the possibility of using them as early biomarkers for diagnosis of diabetic mellitus complications & future prevention. Overall, of 193 participants included in this case-control study, they were divided into three groups: the first one contains patients with type 1 diabetes mellitus (29 with diabetic foot ulcer DFU+ 35 non-diabetic foot), the second group includes type 2 diabetes mellitus patients (41 with DFU + 38 Non). The third group includes (50) as apparently healthy controls. Serological techniques of sandwich ELISA did laboratory tests for specific serum human IL-37, IL-38, and IL- 17A. The study revealed that IL-37 and IL-17A levels were significantly high (P<0.01) in all diabetic groups compared to the control healthy group. The results of IL-38 show substantially higher levels of T1DM and T2DM (P<0.05) compared to the control group. In addition, the DFU group of T2DM illustrated higher levels of IL-37, IL-38, and IL-17A compared with other diabetic groups. In conclusion, Iraqi DM subjects with and without complications had higher values of interleukins, IL-37, IL-38, and IL-17A, than healthy controls, which suggests an inflammatory state in these patients. In addition, the DFU of T2DM patients expressed higher levels of interleukins than other diabetic groups. This can be focused on using them as novel therapeutic targets for preventing and treating DM complications. As well as the possibility of using them as markers of inflammation and progression for complications in DM patients.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Immunological Levels of IL-37, IL-38, and IL-17A in Iraqi Patients with Diabetic Foot Ulcers

AL-Sahi,

AL-Hasnawi,

Ali

2024

Journal-Pharmacy

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“…Diabetes hyperglycemia is hypothesized to lead to immune system malfunction, which makes it difficult for diabetic people to stop the spread of invasive infections. Patients with diabetes are known to be more vulnerable to infections as a result [1,2].…”

Section: Introductionmentioning

confidence: 99%

Microbiological Detection of Some Pathogenic Bacteria in Diabetic Foot Ulcers of Type 1 and 2 Diabetic Mellitus Patients

Marwah M. AL-Sahi,

May Mohammed Ali,

Sawsan M. Jabbar AL-Hasnawi

2023

UTJsci

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Globally, diabetes mellitus (DM) is a serious health issue. Diabetic neuropathy, the most prevalent micro-vascular consequence of diabetes, raises the chance of developing foot ulcers. Different aerobic bacteria, including Gram positive cocci, Staphylococcus aureus, and (beta-haemolytic) Streptococcus are some of the pathogens that can colonize DFUs. Coagulation-negative Staphylococcus (CNS), Corynebacterium, Enterococcus, and Cutibacteria are frequently found in ulcer cultures in clinical practice; however they are typically regarded as colonizing rather than harmful bacteria. Anaerobes are detected in a smaller minority of DFIs and have been associated to altered innate and adaptive immune responses in the hyperglycemic milieu. Gram-negative bacteria account for about one third of DFIs. About 70 participants in all, including 29 individuals with type 1 diabetes and 41 patients with type 2 diabetes who have diabetic foot ulcers. Scarping of ulcers takes place after regular saline wound cleansing to eliminate surface pollutants, and then exudate is sampled. Pus, or discharges from the base of the ulcer, are then submitted to the laboratory as quickly as possible using an aseptic approach. Then, the bacteria were inoculated onto various culture media, such as MacConkey and Blood agar as enrichment media, and incubated aerobically at 37°C for 24 hours to isolate aerobic bacteria. The following day, the bacteria were checked for growth, and a pure colony was then prepared. According to morphological, microscopic, and particular cards of the automated VITEK2 system, isolated bacteria were identified.

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Effectiveness and safety of new oral and injectable agents for in-hospital management of type 2 diabetes in general wards: Systematic review and meta-analysis

Cited by 2 publications

References 33 publications

Evaluation of Immunological Levels of IL-37, IL-38, and IL-17A in Iraqi Patients with Diabetic Foot Ulcers

Evaluation of Immunological Levels of IL-37, IL-38, and IL-17A in Iraqi Patients with Diabetic Foot Ulcers

Microbiological Detection of Some Pathogenic Bacteria in Diabetic Foot Ulcers of Type 1 and 2 Diabetic Mellitus Patients

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