Effectiveness and safety of massage in the treatment of restless legs syndrome

Abstract

Background: Restless legs syndrome (RLS), known as a kind of neurological disease, is prevalent but easy to be ignored. Studies have demonstrated that massage therapy can effectively reduce the symptoms of patients with RLS and improve their quality of life. However, the efficacy of massage therapy for RLS is still controversial. Therefore, this protocol aims to evaluate the reliability of massage therapy in treating RLS in a thorough way. Methods: We will search relevant randomized controlled trials from Chinese Biomedical Literature Database, Chongqing VIP, CNKI, Wanfang, Web of Science, Cochrane Library, PubMed, and EMBASE, when publication status and language are not considered and the time limit ends with September 6, 2020. Two experienced researchers will use RevMan V.5.3 software to perform the selection of literature, data collection, data analysis and synthesis separately. Besides, the quality of trials involved in this study will be measured with the Cochrane bias risk assessment tool. Results: This protocol will be applied to carry out a systematic evaluation of the massage therapy purposed to treat RLS for its effectiveness and safety. Conclusion: The review will provide a credible evidence suggesting whether massage therapy is a reliable intervention for RLS. INPLASY registration number: INPLASY202090038

Restless Leg Syndrome and Sleep Quality in Diabetic Patients with and without Neuropathy

“…Those without neuropathy showed a high percentage of No RLS in them. RLS causes creepy-crawly sensations in the legs and gets resolved by activity 3 . RLS causes an ant sensation in the legs, an irresistible urge to move the legs restlessness and fatigue.…”

“…Restless leg syndrome (RLS) is a sensorimotor sleep-related movement disorder characterized by a strong desire to move one's legs and an uncomfortable sensation in the lower extremities 1 . The prevalence of RLS in the general population is 5 to 15% 2,3 . The unpleasant sensation in the legs improved with movement.…”

Difluorocarbene-Triggered Cyclization: Synthesis of (Hetero)arene-Fused 2,2-Difluoro-2,3-dihydrothiophenes

“…8b Previously, we reported the nucleophilic difluoro-(phenylthio)methylation of a series of electrophiles with PhSCF 2 H using t-BuOK or KOH as the base and found that PhSCF 2 − can readily react with ketones. 9 In view of this, we envisioned that the combination of an aromatic thiolate anion (ArS − ) and difluorocarbene (to in situ generate ArSCF 2 − ) would provide a novel method for nucleophilic difluoro-(arylthio)methylations. However, our initial attempt to difluoromethylate ketones using 2-PySCF 2 − generated in situ from 2-PyS − and a difluorocarbene source such as sodium chlorodifluoroacetate (SCDA) failed to afford the desired product (Scheme 1c).…”