Effectiveness and safety of massage for knee osteoarthritis

Qin, Siyu; Chi, Zhenhai; Xiao, Yuanyi; Zhu, Daocheng; Zhong, Genping; Wei, Xu; Ouyang, Xilin; Li, Jun; Pan, Cheng; Yu, Ting; Li, Haiyan; Jiao, Lin

doi:10.1097/md.0000000000022853

Cited by 7 publications

(4 citation statements)

References 27 publications

(28 reference statements)

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“…Synovial inflammation and KOA treatment are mainly divided into drug therapy, nondrug therapy, and surgical treatment ( 27 ). Currently, there is no effective way to completely cure KOA, and knee replacement is the only treatment for patients with advanced KOA, but it is unlikely to become a common treatment because of its characteristics of high harm, high cost, and low safety ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

Tendon-regulating and bone-setting manipulation promotes the recovery of synovial inflammation in rabbits with knee osteoarthritis via the TLR4–MyD88–NF-κB signaling pathway

Jin¹,

Yu²,

Yang³

et al. 2023

Ann Transl Med

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Background: The aim of this study was to clarify the mechanism of tendon-regulating and bone-setting manipulation in the treatment of knee osteoarthritis (KOA).Methods: A total of 30 adult healthy specific pathogen-free (SPF) New Zealand white rabbits (male; weight 2.0-2.5 kg) were selected and divided into a normal control (NC) group, KOA group, and KOA + manual treatment (MT) group. Each group comprised 10 rabbits. A KOA model was established using the modified Hulth method in the KOA and KOA + MT groups. The 3 groups were fed under the same conditions for 8 weeks. The Lequesne index for KOA. was used to evaluate the behavioral status of the model rabbits; hematoxylin and eosin (HE) staining was employed to observe the pathological morphology of the tibial plateau and medial femoral condyle cartilage; the Mankin scoring scale was used to evaluate the cartilage morphology of the model rabbits; Western blot was used to detect the expression levels of toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), and nuclear factor κB (NF-κB) proteins in the synovial tissue of the model rabbits; the contents of interleukin (IL)-1β, IL-6, and, tumor necrosis alpha (TNF-α) in the synovial fluid of the model rabbits were determined using the enzyme-linked immunosorbent assay (ELISA) method.Results: Compared with those in the NC group, Lequesne index score, Mankin score of cartilage tissue, protein expression, and content of inflammatory factors were significantly increased in the KOA and KOA + MT groups (P<0.05), and these values were significantly higher in the KOA group. Microscopy showed that the cartilage tissue of the experimental rabbits in the KOA and KOA + MT groups was significantly degenerated. Compared with those in the KOA group, the Lequesne index score, Mankin score, protein expression, and inflammatory factor content of the model rabbits in the KOA + MT group were significantly reduced (P<0.05), and microscopy showed that cartilage tissue degeneration of the experimental rabbits in the KOA + MT group was significantly improved.Conclusions: Tendon-regulating and bone-setting manipulation can significantly improve the activity state and motor function of KOA model rabbits and significantly inhibit the expression of the TLR4-MyD88-NF-κB signaling pathway in synovial tissue, thereby reducing knee joint synovial inflammation and delaying the occurrence and development of KOA.

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Section: Discussionmentioning

confidence: 99%

Tendon-regulating and bone-setting manipulation promotes the recovery of synovial inflammation in rabbits with knee osteoarthritis via the TLR4–MyD88–NF-κB signaling pathway

Jin¹,

Yu²,

Yang³

et al. 2023

Ann Transl Med

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“…Massage treatment is a safe and effective nonpharmacological intervention that accelerates blood flow, improves circulation, and promotes edema absorption to relieve knee pain, stiffness, and eliminate edema. At the same time, massage can also improve the flexibility of the knee joint, increase the tension of the muscles around the knee arthrosis, and thus improve the functional state of the knee joint [1]. In a randomized controlled study by Adam I. Perlman et al [14], 68 patients with KOA who had been confirmed by radiography were divided into two groups, one taking standard Swedish massage and the other gaining usual care as a control group.…”

Section: Massage Therapymentioning

confidence: 99%

“…Therefore, future research on KOA should focus on finding safe and efficient methods. In addition, in recent years, with the acceleration of population aging, the prevalence of KOA has gradually increased, which not only affects the quality of people's daily life but also brings heavy medical pressure to society [1]. Therefore, it is urgent to solve the burden that KOA brings to people and society.…”

Section: Conclusion and Prospectmentioning

confidence: 99%

“…Osteoarthritis is a common articular disease in a great number of countries, and the knee joint is the most commonly affected area of osteoarthritis. With the acceleration of global population aging, knee osteoarthritis is becoming a worrying communal fitness problem, which not only imposes a heavy social burden and economic pressures but also affects people's psychological and physical health and quality of life [1]. Knee osteoarthritis (KOA) is a common chronic disease of the musculoskeletal system characterized by degeneration, damage, and osteoporosis of the subchondral bone of the knee arthrosis.…”

Section: Introductionmentioning

confidence: 99%

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Research progress in the treatment of Knee Osteoarthritis

2023

BIO Web Conf.

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Osteoarthritis in the knee is a disease that is chronic and degenerative. It occurs more frequently between the elderly and the obese populations, and the prevalence rate of women is higher than that of men. With the accelerated aging of the population, the prevalence of knee osteoarthritis has also increased, which has brought greater pressure to the patients themselves and society. In recent years, although through the efforts of researchers, there have been a variety of treatment methods for knee osteoarthritis in the clinic, researchers have not yet found a complete cure for knee osteoarthritis. This paper introduces the research status of therapeutic modalities, exercise therapy and traditional therapy in the therapy of knee osteoarthritis by investigating previous research, aiming to promote the level of knee osteoarthritis therapy.

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