Effectiveness and safety of massage for knee osteoarthritis: A protocol for systematic review and meta-analysis

Qin, Siyu; Xiao, Yuanyi; Lin, Jie

doi:10.37766/inplasy2020.8.0115

Cited by 4 publications

(5 citation statements)

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“…Synovial inflammation and KOA treatment are mainly divided into drug therapy, nondrug therapy, and surgical treatment (27). Currently, there is no effective way to completely cure KOA, and knee replacement is the only treatment for patients with advanced KOA, but it is unlikely to become a common treatment because of its characteristics of high harm, high cost, and low safety (28).…”

Section: Discussionmentioning

confidence: 99%

Tendon-regulating and bone-setting manipulation promotes the recovery of synovial inflammation in rabbits with knee osteoarthritis via the TLR4–MyD88–NF-κB signaling pathway

Jin¹,

Yu²,

Yang³

et al. 2023

Ann Transl Med

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Background: The aim of this study was to clarify the mechanism of tendon-regulating and bone-setting manipulation in the treatment of knee osteoarthritis (KOA).Methods: A total of 30 adult healthy specific pathogen-free (SPF) New Zealand white rabbits (male; weight 2.0-2.5 kg) were selected and divided into a normal control (NC) group, KOA group, and KOA + manual treatment (MT) group. Each group comprised 10 rabbits. A KOA model was established using the modified Hulth method in the KOA and KOA + MT groups. The 3 groups were fed under the same conditions for 8 weeks. The Lequesne index for KOA. was used to evaluate the behavioral status of the model rabbits; hematoxylin and eosin (HE) staining was employed to observe the pathological morphology of the tibial plateau and medial femoral condyle cartilage; the Mankin scoring scale was used to evaluate the cartilage morphology of the model rabbits; Western blot was used to detect the expression levels of toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), and nuclear factor κB (NF-κB) proteins in the synovial tissue of the model rabbits; the contents of interleukin (IL)-1β, IL-6, and, tumor necrosis alpha (TNF-α) in the synovial fluid of the model rabbits were determined using the enzyme-linked immunosorbent assay (ELISA) method.Results: Compared with those in the NC group, Lequesne index score, Mankin score of cartilage tissue, protein expression, and content of inflammatory factors were significantly increased in the KOA and KOA + MT groups (P<0.05), and these values were significantly higher in the KOA group. Microscopy showed that the cartilage tissue of the experimental rabbits in the KOA and KOA + MT groups was significantly degenerated. Compared with those in the KOA group, the Lequesne index score, Mankin score, protein expression, and inflammatory factor content of the model rabbits in the KOA + MT group were significantly reduced (P<0.05), and microscopy showed that cartilage tissue degeneration of the experimental rabbits in the KOA + MT group was significantly improved.Conclusions: Tendon-regulating and bone-setting manipulation can significantly improve the activity state and motor function of KOA model rabbits and significantly inhibit the expression of the TLR4-MyD88-NF-κB signaling pathway in synovial tissue, thereby reducing knee joint synovial inflammation and delaying the occurrence and development of KOA.

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Section: Discussionmentioning

confidence: 99%

Tendon-regulating and bone-setting manipulation promotes the recovery of synovial inflammation in rabbits with knee osteoarthritis via the TLR4–MyD88–NF-κB signaling pathway

Jin¹,

Yu²,

Yang³

et al. 2023

Ann Transl Med

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“…(4) 5) AUC (Area Under Curve, AUC) indicates the area under the ROC (receiver operating characteristic curve, ROC) curve. The formula for calculating AUC is as follows: (5) where, TPR represents the true positive rate and FPR represents the false positive rate.…”

Section: B Performance Evaluation Indicatorsmentioning

confidence: 99%

“…Knee diseases encompass a wide range of symptoms and dysfunctions, underscoring the importance of recognizing abnormal subjective knee symptoms for early treatment and management. Researchers have explored multiple models and methods based on knee risk factors, symptoms, and etiology to develop diagnostic models for knee diseases and investigate symptom-based identification [5]. For example, Lim et al employed deep learning algorithms to predict osteoarthritis using a Korean database [6], while Snoeker et al designed a questionnaire for diagnosing meniscal injuries [7].…”

Section: Introductionmentioning

confidence: 99%

Research on Diagnosis Method of Common Knee Diseases Based on Subjective Symptoms and Random Forest Algorithm

Wang,

Hu,

et al. 2024

IJACSA

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Knee diseases are common diseases in the elderly, and timely and effective diagnosis of knee diseases is essential for disease treatment and rehabilitation training. In this study, we construct a diagnostic model of common knee diseases based on subjective symptoms and random forest algorithm to realize patients' self-initial diagnosis. In this paper, we first constructed a questionnaire of subjective symptoms of knee, and set up a questionnaire system to guide users to fill out the questionnaire correctly. Then clinical data collection is carried out to obtain clinical questionnaire data. Finally, the diagnostic analysis of three common diseases of knee joint is carried out by random forest machine learning method. Through leave-one-out cross validation, the accuracy of meniscus injury, anterior cruciate ligament injury and knee osteoarthritis diseases are 0.79, 0.84, 0.81 respectively; the sensitivity is 0.79, 0.84, 0.88 respectively; and the specificity is 0.80, 0.84, 0.79 respectively. The results show that the method can achieve a good effect of self-diagnosis, and can provide a knee joint disease screening a convenient and effective approach.

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“…Massage is a popular therapeutic measure and frequently encountered component within PT programs for osteoarthritic dogs. In people, massage has been shown to increase circumarticular blood circulation, to improve muscular tension and joint flexibility [ 94 ]. Additionally, systemic effects such as changes in the vegetative nervous system with reduction of stress and anxiety have been induced by massage [ 95 , 96 , 97 ].…”

Section: Physical Therapy Pyramidmentioning

confidence: 99%

Physiotherapeutic Strategies and Their Current Evidence for Canine Osteoarthritis

Mille

McClement

Lauer

2022

Veterinary Sciences

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Osteoarthritis (OA) is a common and debilitating condition in domestic dogs. Alongside pharmaceutical interventions and weight loss, exercise and physiotherapy (PT) are important measures in maintaining patient mobility and quality of life. Physiotherapy for OA aims to reduce pain, optimize muscular function and maintain joint function. Physiotherapeutic plans typically include PT exercises combined with therapeutic modalities, lifestyle and environmental modifications to improve the patient’s overall quality of life and function. Information on therapeutic clinical efficacy of physiotherapeutic measures for canine OA is still very limited. Thus, physiotherapeutic strategies are still primarily based on evidence extrapolated from human protocols tailored to people with OA. The authors propose a simple systematic PT approach for canine OA, prioritizing measures according to simplicity, cost effectiveness and practicality. This guide (the “Physiotherapy Pyramid”) aims to provide a clear stratified approach to simplify decision making and planning for owners, veterinarians and veterinary physiotherapists, leading to more straightforward design and implementation of treatment plans. Measures are implemented starting at the base of the pyramid, subsequently progressing to the top, allowing effective and practical interventions to be prioritized. The levels of the pyramid are in ascending order: environmental modification, exercise plan, OA-specific home exercises and treatment by a veterinary physiotherapist.

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Effectiveness and safety of massage for knee osteoarthritis: A protocol for systematic review and meta-analysis

Abstract: To cite: Qin et al. Effectiveness and safety of massage for knee osteoarthritis: A protocol for systematic review and meta-analysis. Inplasy protocol 202080115.

Cited by 4 publications

References 0 publications

Tendon-regulating and bone-setting manipulation promotes the recovery of synovial inflammation in rabbits with knee osteoarthritis via the TLR4–MyD88–NF-κB signaling pathway

Tendon-regulating and bone-setting manipulation promotes the recovery of synovial inflammation in rabbits with knee osteoarthritis via the TLR4–MyD88–NF-κB signaling pathway

Research on Diagnosis Method of Common Knee Diseases Based on Subjective Symptoms and Random Forest Algorithm

Physiotherapeutic Strategies and Their Current Evidence for Canine Osteoarthritis

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