Effectiveness and safety of Injinoryung-San-Gagambang (Yinchen Wuling powder) decoction on stroke patients with elevated serum liver enzymes

Abstract

Rationale:Injinoryung-San-Gagambang (IJORS) effectively improves hepatic dysfunction caused by polypharmacy in stroke patients.Patient concerns:We present 3 cases of hepatic dysfunction caused by polypharmacy, one of which was a 51-year-old man with cerebellum infarction and pneumonia as a complication of stroke. He took multiple medications because of baseline diseases. After recurrence of pneumonia, his laboratory tests showed abnormal aminotransferase levels. Another patient was an 81-year-old woman with cerebral infarction at the right-middle cerebral artery. She was also taking >5 medications. Her laboratory tests conducted on admission showed abnormally elevated aminotransferase levels. The last patient was 77-year-old man with cerebral infarction at the left-middle cerebral artery. He also had an abdominal aneurysm, a thoracic aortic aneurysm, and a myocardial infarction. After taking multiple medications including healthy functional foods, his laboratory tests showed abnormally elevated aminotransferase levels.Diagnosis:Diagnosis is conducted with the result of laboratory test including blood count, chemistry test.Interventions:All 3 patients received the same herbal treatment (IJORS decoction) for 1 to 3 weeks.Outcomes:All 3 patients’ abnormal serum aminotransferase level were significantly improved by IJORS decoction treatment while keeping other medicines.Lessons:IJORS can be considered as an effective treatment for hepatic dysfunction induced by numerous medications in stroke patients.

Four Case Reports on Treatment of elevated aminotransferase levels with Herbal medicine containing Artemisia capillaris as Principal Component

“…However, the reliability of these cases is not expected to be low, since a clear improvement of abnormal ATLs after herbal medicine treatment has been confirmed, and these cases are consistent with the results of the previous studies. 10,24) Despite these limitations, this study suggests the possibility of applying HMA to liver disease. If larger scale and prospective method studies conducted on the same topic in the future, it will (427) lead to more specific and clearer conclusions about the potential power of herbal medicine`s use of hepatic disease.…”

“…7,8,9) Furthermore, we have also reported some cases with improved ATLs after herbal medicine administration. 10,11) These mean that herbal medicine can be safe intervention and have therapeutic effect for liver dysfunction as long as it is prescribed properly. 12) In our previous study, we only reported the cases of Injin-Oryongsan single decoction treatment.…”

“…12) In our previous study, we only reported the cases of Injin-Oryongsan single decoction treatment. 10,11) We analyzed hospitalized patients` cases who had abnormal value of ATLs and treated with herbal medicine that included Artemisia capillaris as an extension of our previous study.…”

Traditional Chinese medicine in the treatment of patients with hyperuricemia: A randomized placebo‐controlled double‐blinded clinical trial

“…A clinical study observed that it can slightly improve hepatic dysfunction in stroke patients. 6 In this study, we investigated the efficacy and safety of Wu-Ling San and Yin Chen Wu-Ling San in patients with gout through a double-blinded, placebo-controlled clinical trial to clarify the potential clinical benefit of these TCM in patients with gout.…”

“…This formulation is recommended for conditions such as jaundice, oliguria, hyperlipidemia, and a fatty liver. A clinical study observed that it can slightly improve hepatic dysfunction in stroke patients 6 …”