Effectiveness and Safety of Botulinum Toxin Type A in the Treatment of Androgenetic Alopecia

Zhou, Yujia; Yu, Shui; Zhao, Jianlin; Feng, Xinyue; Zhang, Meinan; Zhao, Zhiyun

doi:10.1155/2020/1501893

Cited by 42 publications

(63 citation statements)

References 30 publications

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“…Finally, Zhou et al [22] performed a randomized trial to assess botulinum toxin type A injections as a monotherapy and in combination with oral finasteride for efficacy and safety in AGA. In total, 63 men aged 18-60 years were recruited in China with AGA classifications of Norwood II-IV, and with no prior treatment history of drugs that may interfere with botulinum toxin in the last 6 months.…”

Section: Investigationsmentioning

confidence: 99%

Use of Botulinum Toxin for Androgenic Alopecia: A Systematic Review

English¹,

Ruiz²

2021

Skin Appendage Disord

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In this systematic review, we summarize the efficacy and safety of intradermal and intramuscular botulinum toxin injections for androgenic alopecia (AGA). Using PubMed, we conducted a literature search up to February 2021 using the following keyword combinations: “botulinum toxin” or “botox” and “androgenetic alopecia,” “hair loss,” or “alopecia.” Five clinical studies met our inclusion criteria: 4 prospective cohorts and 1 randomized clinical trial (RCT). Study durations ranged from 24 to 60 weeks. No studies included control groups or compared botulinum toxin injections against approved treatments. A total of 165 participants were identified – all of whom were males with AGA. Of the 4 studies measuring response rates (i.e., subjects with >0% hair changes), response rates ranged from 75 to 79.1%. Within studies measuring hair count changes from intramuscular injections, changes ranged from 18 to 20.9%. No serious adverse events were reported. Studies on botulinum toxin injections have produced favorable outcomes for AGA subjects. However, results should be interpreted with caution due to the absence of control groups, small numbers of participants, and relatively low Jadad quality scores. Large RCTs are recommended to confirm efficacy and safety, explore the effects of botulinum toxin on females with pattern hair loss, and establish best practices for intradermal and intramuscular injection methodologies.

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Section: Investigationsmentioning

confidence: 99%

Use of Botulinum Toxin for Androgenic Alopecia: A Systematic Review

English¹,

Ruiz²

2021

Skin Appendage Disord

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show abstract

“…Earlier studies have indicated that the supplementation of antioxidants such as vitamin C, vitamin E and glutathione improves spermatogenesis and sperm quality [ 53 , 54 ]. Recent studies have demonstrated that the use of therapeutic BoNT reduced oxidative stress in animal models and plasma of patients [ 22 , 55 , 56 ].…”

Section: Discussionmentioning

confidence: 99%

Single injection of very mild dose botulinum toxin in the vastus lateralis improves testicular spermatogenesis and sperm motility in ageing experimental mice

et al. 2022

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Background Botulinum toxin (BoNT) is a widely used therapeutic agent that blocks the excessive release of acetylcholine at the neuromuscular junction. Previously, repeated intracremasteric injections and slight overdose of BoNT have been reported to induce adverse effects in the testicular parameter of experimental rodents. However, a mild dose of BoNT is highly beneficial against skin ageing, neuromuscular deficits, overactive urinary bladder problems, testicular pain and erectile dysfunctions. Considering the facts, the possible therapeutic benefits of BoNT on the testis might be achieved at a very minimal dosage and via a distal route of action. Therefore, we revisited the effect of BoNT, but with a trace amount injected into the vastus lateralis of the thigh muscle, and analyzed histological parameters of the testis, levels of key antioxidants and sperm parameters in ageing experimental mice. Results Experimental animals injected with 1 U/kg bodyweight of BoNT showed enhanced spermatogenesis in association with increased activities of key antioxidants in the testis, leading to enhanced amount of the total sperm count and progressive motility. Conclusions This study signifies that a mild intramuscular dose of BoNT can be considered as a potent treatment strategy to manage and prevent male infertility.

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“…Earlier studies have indicated that the supplementation of antioxidants like vitamin C, vitamin E and glutathione improve spermatogenesis and sperm quality [47,48]. Recent studies have demonstrated that the use of therapeutic botulinum toxin reduced oxidative stress in animal models and plasma of patients [22,49,50], Yesudhas et al has recently reported that BOTOX® improves the antioxidant enzyme activity and provide neuroprotection in the brain of ageing experimental animals [11,23].…”

Section: Discussionmentioning

confidence: 99%

Single injection of very mild dose BOTOX in the vastus lateralis improves testicular spermatogenesis and sperm motility in ageing experimental mice

Radhakrishnan

Ravichandran

Sukesh

et al. 2021

Preprint

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Acetylcholine (ACh), a key neurochemical messenger that plays key roles in neuroplasticity and muscle contraction. While ACh is important for the physiological function of the testis, abnormal levels of ACh cause testicular atrophy and male infertility. BOTOX is a therapeutic form of the botulinum neurotoxin that blocks the excessive release of ACh at the neuromuscular junction. Previously, repeated intracremasteric injections and slight overdose of BOTOX have been reported to induce adverse effects in the testicular parameter of experimental rodents. However, a mild dose of BOTOX is highly beneficial against skin ageing, neurological deficits, overactive urinary bladder problems, testicular pain and erectile dysfunctions. Considering the facts, the possible therapeutic benefit of BOTOX on the testis might be achieved via its minimal dose and indirect mode of action rather than repeated high quantity in the local supply. Therefore, we revisited the effect of BOTOX but with a trace amount injected into the vastus lateralis of the thigh muscle, and analyzed histological parameters of testis and quality of semen in ageing experimental mice. Experimental animals injected with 1 U/kg bodyweight of BOTOX showed enhanced spermatogenesis in associations with increased activities of key antioxidants in the testis, leading to increased total sperm count and motility. This study signifies that a mild intramuscular dose of BOTOX can be considered as a potential treatment strategy to manage and prevent male infertility.

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Effectiveness and Safety of Botulinum Toxin Type A in the Treatment of Androgenetic Alopecia

Cited by 42 publications

References 30 publications

Use of Botulinum Toxin for Androgenic Alopecia: A Systematic Review

Use of Botulinum Toxin for Androgenic Alopecia: A Systematic Review

Single injection of very mild dose botulinum toxin in the vastus lateralis improves testicular spermatogenesis and sperm motility in ageing experimental mice

Single injection of very mild dose BOTOX in the vastus lateralis improves testicular spermatogenesis and sperm motility in ageing experimental mice

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