Effectiveness and safety of bedaquiline-based, modified all-oral 9–11-month treatment regimen for rifampicin-resistant tuberculosis in Vietnam

Efficacy and safety of bedaquiline containing regimens in patients of drug-resistant tuberculosis: An updated systematic review and meta-analysis

“…In total, 41 studies are included in the updated version of this review. The studies [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] were divided into two groups: 36 observational studies including a total of 9,934 patients, and 5 experimental studies including a total of 468 patients. The patient’s mean age was 36.2 years.…”

“…A meta -analysis was conducted in 2021 that pooled the results of these studies [21] . However, results from additional well-designed observational and experimental studies were published [19] , [20] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] . To better analyze the effectiveness and safety of bedaquiline in MDR-TB, we conducted an updated meta -analysis.…”

Six Months of Bedaquiline-Pretomanid-Linezolid (BPaL) Regimen in Patients with Drug-Resistant Tuberculosis: A Narrative Review

“…Meanwhile, unfavorable outcomes including treatment failure, death, and loss of follow-up were 4%, 1%, and 6%, respectively. [22] Furthermore, a study by Avaliani et al demonstrated that in MDR-TB patients in Georgia receiving five drugs of STR (bedaquiline, linezolid, levofloxacin, clofazimine, and cycloserine), the treatment success was 22/25 (88%). [23] Treatment success of more than 90% in Bedaquiline, Pretomanid, and Linezolid ( BPaL) regimen was higher compared to the study by Soeroto et al, who reported that 64.5% of successful treatment in Indonesian MDR/RR-TB patients treated with the second line injectablecontaining 7-drug STR [3].…”

CLPC1 protein inhibition, antimycobacterial, and anti‐inflammatory properties of the metabolite from Streptomyces wuyuanensis collected in Nghe An province, Vietnam

“…4 The Vietnamese National Tuberculosis Control Program reported that 8400 new cases of rifampicin-resistant and multidrug-resistant tuberculosis were found in Vietnam in 2021 as well. 5 Thus, multidrug-resistant (MDR) tuberculosis is one of the biggest challenges for scientists. The 1st, 2nd, and 3rd generation antibiotic such as rifampicin, isoniazid, pyrazinamide, clofazimine, rifapentine, etc.…”

“…WHO estimated that there were about 174 000 new cases and 11 000 deaths in Vietnam in 2021 4 . The Vietnamese National Tuberculosis Control Program reported that 8400 new cases of rifampicin‐resistant and multidrug‐resistant tuberculosis were found in Vietnam in 2021 as well 5 . Thus, multidrug‐resistant (MDR) tuberculosis is one of the biggest challenges for scientists.…”