Effectiveness and safety of acupuncture in post-stroke depression (PSD)

Chen, Baishu; Zhao, Minhong; Chen, Bin; Yang, Zhenjiang; Yu, Xiaojiang; Xueying, Lin; Fan, Chun

doi:10.1097/md.0000000000018969

Cited by 7 publications

(6 citation statements)

References 24 publications

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“…The pathophysiology of PSD is remarkably complicated and, at present, poorly understood ( Villa et al, 2018 ; Chen et al, 2020a ); factors including both biological and psychosocial factors are likely to be involved. No single pathophysiological mechanism fully explains PSD ( Loubinoux et al, 2012 ).…”

Section: Pathophysiological Mechanisms Of Psdmentioning

confidence: 99%

Natural Products for the Treatment of Post-stroke Depression

Fang

Zhang

et al. 2022

Front. Pharmacol.

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Post-stroke depression (PSD) is the most frequent and important neuropsychiatric consequence of stroke. It is strongly associated with exacerbated deterioration of functional recovery, physical and cognitive recoveries, and quality of life. However, its mechanism is remarkably complicated, including the neurotransmitters hypothesis (which consists of a monoaminergic hypothesis and glutamate-mediated excitotoxicity hypothesis), inflammation hypothesis, dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis, and neurotrophic hypothesis and neuroplasticity. So far, the underlying pathogenesis of PSD has not been clearly defined yet. At present, selective serotonin reuptake inhibitors (SSRIs) have been used as the first-line drugs to treat patients with PSD. Additionally, more than SSRIs, a majority of the current antidepressants complied with multiple side effects, which limits their clinical application. Currently, a wide variety of studies revealed the therapeutic potential of natural products in the management of several diseases, especially PSD, with minor side effects. Accordingly, in our present review, we aim to summarize the therapeutic targets of these compounds and their potential role in-clinic therapy for patients with PSD.

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Section: Pathophysiological Mechanisms Of Psdmentioning

confidence: 99%

Natural Products for the Treatment of Post-stroke Depression

Fang

Zhang

et al. 2022

Front. Pharmacol.

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“…Studies (Ng et al, 2007) have shown that the two most severe ischemic strokes are those in more than one vascular territory (MVT) and MCA. These strokes both cause severe neurocognitive impairments encompassing executive functions, memory, attention, and behavioral issues, such as depression, agitation, and abulia (van Lieshout et al, 2019;Busk et al, 2020;Chen et al, 2020;Draaisma et al, 2020;Syafrita et al, 2020). MCA strokes may even lead to further visuospatial cognitive impairments and impaired language.…”

Section: Introductionmentioning

confidence: 99%

Effect of Panax notoginseng Saponins on Focal Cerebral Ischemia-Reperfusion in Rat Models: A Meta-Analysis

et al. 2021

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With the increase of the aging population, the high mortality and disability rates caused by ischemic stroke are some of the major problems facing the world, and they dramatically burden the society. Panax notoginseng (Burk) F. H. Chen, a traditional Chinese medicine, is commonly used for promoting blood circulation and removing blood stasis, and its main bioactive components are Panax notoginseng saponins (PNS). Therefore, we performed a meta-analysis on focal cerebral ischemia-reperfusion animal models established with middle cerebral artery occlusion (MCAO) surgery to evaluate the therapeutic effect of PNS. We systematically searched the reports of PNS in MCAO animal experiments in seven databases. We assessed the study quality using two literature quality evaluation criteria; evaluated the efficacy of PNS treatment based on the outcomes of the neurological deficit score (NDS), cerebral infarct volume (CIV), and biochemical indicators via a random/fixed-effects model; and performed a subgroup analysis utilizing ischemia duration, drug dosage, intervention time, and administration duration. We also compared the efficacy of PNS with positive control drugs or combination treatment. As a result, we selected 14 eligible studies from the 3,581 searched publications based on the predefined exclusion-inclusion criteria. PNS were significantly associated with reduced NDS, reduced CIV, and inhibited release of the inflammatory factors IL-1β and TNF-α in the focal MCAO rat models. The PNS combination therapy outperformed the PNS alone. In addition, ischemia time, drug dosage, intervention time, and administration duration in the rat models all had significant effects on the efficacy of PNS. Although more high-quality studies are needed to further determine the clinical efficacy and guiding parameters of PNS, our results also confirmed that PNS significantly relieves the focal cerebral ischemia-reperfusion in rat models. In the animal trials, it was suggested that an early intervention had significant efficacy with PNS alone or PNS combination treatment at a dosage lower than 25 mg/kg or 100–150 mg/kg for 4 days or longer. These findings further guide the therapeutic strategy for clinical cerebral ischemic stroke.

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“…Thus, St. John's wort has been compared with other CAM treatments, such as acupuncture and massage. The two top recent keywords were "protocol" and "systematic review"; therefore, numerous studies and significant articles are expected to be published in in this field, including systematic studies [26][27][28][29][30][31]. Keyword analysis based on temporal order can reveal changes in processes in the fields of interest.…”

Section: Discussionmentioning

confidence: 99%