Effectiveness and safety of a robot-assisted 3D personalized template in 125I seed brachytherapy of thoracoabdominal tumors

Ma, Xiaodong; Yang, Zhiyong; Jiang, Shan; Huo, Bin; Cao, Qiang; Chai, Shude; Wang, Haitao

doi:10.5114/jcb.2018.77957

Cited by 11 publications

(5 citation statements)

References 36 publications

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“…In Ma et al . study, V 100 and D 90 were 5% and 8%, and the 2-year overall survival and local control rates improved to 18.9% and 23.3%, respectively [13]. Therefore, 3DPNCT planning demonstrated a potential advantage to increase local control rate and to reduce recurrence.…”

Section: Discussionmentioning

confidence: 99%

Comparative study for CT-guided 125 I seed implantation assisted by 3D printing coplanar and non-coplanar template in peripheral lung cancer

Ji¹,

Sun²,

Jiang³

et al. 2019

jcb

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Purpose We compared the three-dimensional printed non-coplanar template (3DPNCT) plans with 3D-printed coplanar template (3DPCT) plans for radioactive seed implantation (RSI) in lung cancer and explored the differences between the two technologies. Material and methods 33 patients with peripheral lung cancer that received 3DPCT-assisted RSI in our department between June 2017 and February 2018 were analyzed. A 3DPNCT plan was re-designed for all patients. The prescribed dose and seed activity in the new plan were the same as the 3DPCT plan. The data in the two plans were compared, including seed number, needle number, number of needles needed to cross the ribs, and dosimetry parameters. Dosimetry parameters included D 90 , D mean , MPD (minimum peripheral dose), V 100 , V 150 , CI (conformity index), EI (external index), HI (homogeneity index) of target volume, D 2cc of spinal cord and aorta, and V 20 of affected side lung. We used a paired t -test and two groups of related non-parameters tests to examine statistical significance. A p value < 0.05 was considered statistically significant. Results We found no significant difference in dosimetry parameters ( p > 0.05), except MPD. The mean MPD of the 3DPNCT plan was significantly higher than the 3DPCT plan (88.5 Gy and 81.8 Gy, respectively, p = 0.017). The number of needles used in the 3DPNCT plan and the number of needles needed to cross the ribs were significantly less compared with the 3DPCT plan ( p = 0.000). Conclusions The dose distributions of the two 3DPCT plans were similar. 3DPNCT plan had a higher dose in target volume margin, with fewer needles and fewer breaks to the ribs.

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Section: Discussionmentioning

confidence: 99%

Comparative study for CT-guided 125 I seed implantation assisted by 3D printing coplanar and non-coplanar template in peripheral lung cancer

Ji¹,

Sun²,

Jiang³

et al. 2019

jcb

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“…[9,[34][35][36][37][38][39][40] Recently, the advantage of a robotic implantation with the use of a personalized 3D printed template compared to the manual implantation with personalized 3D printed template guidance was documented. [41] Some groups use seed implants, other the HDR stepping source technology. In HDR practice, dose distribution can be better personalized by adjusting dwell times and dwell distances, which allow conformal radiation delivery.…”

Section: Discussionmentioning

confidence: 99%

Interventional Oncology: Should Interventional Radiotherapy (Brachytherapy) be Integrated into Modern Treatment Procedures?

Kovács¹

2019

TJ Oncol

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The delivery of a very high dose by radiotherapy to a dedicated target with minimal surrounding normal tissue dose is a challenging situation. From a radiotherapy point of view, in several anatomic situations, the most optimal method is the use of interventional radiotherapy (brachytherapy; IRT) alone or in combination with other established interventional tumor cell eliminating methods. METHODS First, Interventional Radiotherapy, Interventional Radiology, Interventional Endoscopy and Interventional Chemotherapy have the same aim of eliminating tumor tissue. Second, target definition and some IRT application techniques need multidisciplinary teamwork. RESULTS Multidisciplinary teams have the best potential to offer the best possible cure in localized solid tumors or in selected oligometastatic disease. Examples for this kind of service are given for H&N-, anal-, vaginal-, breast-, prostate cancers as well as in oligometastatic disease. The combined use of interventional tumor ablation techniques is demonstrated. CONCLUSION Interventional Oncology has the potential to improve the treatment results in localized solid cancers or in selected oligometastatic disease, and large workload Interventional Oncology Centers could have an important role in the patient service, in the education as well as in the clinical research.

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“…Traditional methods of lung area LDR brachytherapy require doctors to position needles guided by CT images. Ma X et al 10 presented a method for radioactive seed implantation for lung cancer brachytherapy assisted by a CT image-guided system and achieved a good outcome. However, this method requires frequent CT scans during surgery and the accuracy is low.…”

Section: Introductionmentioning

confidence: 99%

Design and validation of a surgical navigation system for brachytherapy based on mixed reality

et al. 2019

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Purpose An accurate position of the needle is vitally important in low‐dose‐rate seed implantation brachytherapy. Our paper aims to implement a mixed reality navigation system to assist with the placement of the I125 seed implantation thoracoabdominal tumor brachytherapy needle and to validate the accuracy and quality of this type of method. Methods With the surgical navigation system, based on mixed reality through a novel modified multi‐information fusion method, the fusion of virtual organs and a preoperative plan for a real patient and the tracking of surgical tools in real time were achieved. Personalized image recognition and pose estimation were used to track needle punctures in real time and to perform registration processes. After a one‐time registration with a hexagonal prism tracker that used an iterative closest point algorithm, all information, including medical images and volume renderings of organs, needles, and seeds, was precisely merged with the patient. Doctors were able to observe the tumor target and to visualize the preoperative plan. This system was validated in both phantom and animal experiments. The accuracy of this system was validated by calculating the positional and rotational error of each needle insertion. The accuracy of implantation of each seed was determined in an animal experiment to test the accuracy in low‐dose‐rate brachytherapy. The efficiency of this system was also validated through time consumption assessments. Results In the phantom experiment, the average error of the needle locations was 0.664 mm and the angle error was 4.74°, average time consumption was 16.1 min with six needles inserted. Based on the results of the animal experiment, the accuracy of the needle insertion was 1.617 mm, while the angle error was 5.574° and the average error of the seed positions was 1.925 mm. Conclusions This paper describes the design and experimental validation of a novel surgical navigation system based on mixed reality for I125 seed brachytherapy for thoracoabdominal tumors. This system was validated through a series of experiments, including phantom experiments and animal experiments. Compared with the traditional image‐guided system, the procedure presented here is convenient, displays clinically acceptable accuracy and reduces the number of CT scans, allowing doctors to perform surgery based on a visualized plan. All the experimental results indicated that the procedure is ready to be applied in further clinical studies.

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Effectiveness and safety of a robot-assisted 3D personalized template in 125I seed brachytherapy of thoracoabdominal tumors

Cited by 11 publications

References 36 publications

Comparative study for CT-guided 125 I seed implantation assisted by 3D printing coplanar and non-coplanar template in peripheral lung cancer

Comparative study for CT-guided 125 I seed implantation assisted by 3D printing coplanar and non-coplanar template in peripheral lung cancer

Interventional Oncology: Should Interventional Radiotherapy (Brachytherapy) be Integrated into Modern Treatment Procedures?

Design and validation of a surgical navigation system for brachytherapy based on mixed reality

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