Effectiveness and Harms of Using Kidneys with Small Renal Tumors from Deceased or Living Donors as a Source of Renal Transplantation: A Systematic Review

Hevia, Vital; Zakri, Rhana Hassan; Taylor, Claire; Bruins, H.M.; Boissier, R.; Lledó, E.; Regele, Heinz; Budde, Klemens; Figueiredo, Arnaldo; Breda, Alberto; Yuan, Yuhong; Olsburgh, Jonathon

doi:10.1016/j.euf.2018.01.018

Cited by 14 publications

(8 citation statements)

References 21 publications

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“…Taking together, we would support use of the restored kidney grafts for transplantation after ex vivo excision of a small tumour as a novel source. Our study will provide additional supporting evidence to the recent literature review by Hevia et al that kidney transplant by using kidneys after excised low‐grade small renal tumours appears to be safe in terms of overall survival, graft survival and oncological outcomes in appropriate selected recipients [46]. Establishment of a structured programme would facilitate expanding utilization of this type of kidney grafts.…”

Section: Discussionsupporting

confidence: 73%

Long‐term outcome of kidney transplant by using restored kidney grafts after tumour ex vivo excision – a prospective study

Mou

et al. 2020

Transpl Int

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The aim of this study is to report long-term outcomes of kidney transplantation by using the kidney graft after a small tumour ex vivo excision. A structured programme was established to use the restored kidney graft from urological referral after radical nephrectomy. The criteria were defined as tumour size ≤3 cm, margin clear on frozen section and recipients aged ≥60 years or those on the urgent list for transplantation as a result of imminent lack of dialysis access. The recipients were followed up regularly for surveillance of tumour recurrence. Between February 2007 and February 2018, 28 recipients had kidney transplantation by using the restored kidney grafts. The tumour size was 2.6 AE 0.7 cm. The follow-up was median 7 years without evidence of tumour recurrence. The patient and graft survival was satisfactory. Kidney transplantation by using restored kidneys after a small tumour excision is a novel source for selected recipients. The long-term patient and graft survival is satisfactory. Although there is a risk of tumour recurrence, it is rare event. Together with literature review, we would support use of kidney graft after a small tumour excision for selected recipients.

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Section: Discussionsupporting

confidence: 73%

Long‐term outcome of kidney transplant by using restored kidney grafts after tumour ex vivo excision – a prospective study

Mou

et al. 2020

Transpl Int

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“…Similarly, Hevia et al 8 described a 95.6% overall graft survival rate and a 100% recurrence-free survival rate at a five-year follow-up. The mean tumor size was 2 cm.…”

mentioning

confidence: 81%

Is it Possible to Use Kidneys with Small Renal Masses for Transplant? A New Strategy to Face Kidney Graft Shortage for Transplantation in Ibero-America

Castañeda-Millán

García‐Perdomo

Alcaraz

2021

Revista Urología Colombiana / Colombian Urology Journal

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“…67 A systematic review of published cases until June 2017 identified 109 such transplantations. 68 Most excised tumors were RCC (81%), mean tumor size was 2 cm (range 0.5–6.0 cm; predominantly <4 cm), and nucleolar/Fuhrman grade I–II in 93%, all had clear margins. Mean follow-up was 39.9 mo, there was only 1 local tumor relapse (after 9 y), other outcomes were inconsistently reported.…”

Section: Reveiwmentioning

confidence: 94%

“…Most transplant programs restrict these “restored” kidneys to patients >60 y of age or who have dialysis access problems and require recipient consent. 68 …”

Section: Reveiwmentioning

confidence: 99%

“…There is no consensus on the acceptable size of tumor before restoration of a donor kidney for transplantation though several reviews mention <4 cm, 68 , 70 some <3 cm. 29 The Council of Europe stratify risk according to size and grade of the RCC, that is, <1, 1–4, and 4–7 cm as minimal, low, and intermediate risk, respectively, conditional on nucleolar/Fuhrman grade I–II.…”

Section: Reveiwmentioning

confidence: 99%

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Renal Cell Carcinoma and Kidney Transplantation: A Narrative Review

et al. 2021

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Effectiveness and Harms of Using Kidneys with Small Renal Tumors from Deceased or Living Donors as a Source of Renal Transplantation: A Systematic Review

Cited by 14 publications

References 21 publications

Long‐term outcome of kidney transplant by using restored kidney grafts after tumour ex vivo excision – a prospective study

Long‐term outcome of kidney transplant by using restored kidney grafts after tumour ex vivo excision – a prospective study

Is it Possible to Use Kidneys with Small Renal Masses for Transplant? A New Strategy to Face Kidney Graft Shortage for Transplantation in Ibero-America

Renal Cell Carcinoma and Kidney Transplantation: A Narrative Review

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