Effectiveness and acceptability of non-pharmacological interventions in people with mild cognitive impairment: Overview of systematic reviews and network meta-analysis

Hu, Mingyue; Hu, Hongxing; Shao, Zhanfang; Gao, Yinyan; Zeng, Xianmei; Shu, Xinhui; Huang, Jundan; Shen, Shanshan; Wu, Irene; Xiao, Lily Dongxia; Feng, Hui

doi:10.1016/j.jad.2022.05.043

Cited by 12 publications

(4 citation statements)

References 34 publications

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“…Non-pharmacological interventions to prevent and treat cognitive deficits and the associated difficulties with activities of daily living in neurodegenerative disease patients have gained attention in recent years. Among these interventions, cognitive training offers a potential approach for dementia prevention and for the improvement of cognitive functions ( Cappa et al, 2003 ; Cotelli et al, 2006 ; Bahar-Fuchs et al, 2013a , 2013b ; Yao et al, 2020 ; Hu et al, 2022 ). A critical aspect of cognitive training programs is that the most promising interventions involve intensive in-person sessions that are unlikely to be cost-effective or feasible for large-scale implementation ( Botsis et al, 2008 ; Brennan et al, 2009 ; Corbetta et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Long-lasting improvements in episodic memory among subjects with mild cognitive impairment who received transcranial direct current stimulation combined with cognitive treatment and telerehabilitation: a multicentre, randomized, active-controlled study

Manenti,

Baglio,

Pagnoni

et al. 2024

Front. Aging Neurosci.

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BackgroundIn recent years, an increasing number of studies have examined the potential efficacy of cognitive training procedures in individuals with normal ageing and mild cognitive impairment (MCI).ObjectiveThe aims of this study were to (i) evaluate the efficacy of the cognitive Virtual Reality Rehabilitation System (VRRS) combined with anodal transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex compared to placebo tDCS stimulation combined with VRRS and (ii) to determine how to prolong the beneficial effects of the treatment. A total of 109 subjects with MCI were assigned to 1 of 5 study groups in a randomized controlled trial design: (a) face-to-face (FTF) VRRS during anodal tDCS followed by cognitive telerehabilitation (TR) (clinic-atDCS-VRRS+Tele@H-VRRS); (b) FTF VRRS during placebo tDCS followed by TR (clinic-ptDCS-VRRS+Tele@H-VRRS); (c) FTF VRRS followed by cognitive TR (clinic-VRRS+Tele@H-VRRS); (d) FTF VRRS followed by at-home unstructured cognitive stimulation (clinic-VRRS+@H-UCS); and (e) FTF cognitive treatment as usual (clinic-TAU).ResultsAn improvement in episodic memory was observed after the end of clinic-atDCS-VRRS (p < 0.001). We found no enhancement in episodic memory after clinic-ptDCS-VRRS or after clinic-TAU.Moreover, the combined treatment led to prolonged beneficial effects (clinic-atDCS-VRRS+Tele@H-VRRS vs. clinic-ptDCS-VRRS+Tele@H-VRRS: p = 0.047; clinic-atDCS-VRRS+Tele@H-VRRS vs. clinic-VRRS+Tele@H-VRRS: p = 0.06).DiscussionThe present study provides preliminary evidence supporting the use of individualized VRRS combined with anodal tDCS and cognitive telerehabilitation for cognitive rehabilitation.Clinical trial registrationhttps://clinicaltrials.gov/study/NCT03486704?term=NCT03486704&rank=1, NCT03486704.

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Section: Discussionmentioning

confidence: 99%

Long-lasting improvements in episodic memory among subjects with mild cognitive impairment who received transcranial direct current stimulation combined with cognitive treatment and telerehabilitation: a multicentre, randomized, active-controlled study

Manenti,

Baglio,

Pagnoni

et al. 2024

Front. Aging Neurosci.

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“…The education program ( 20 , 21 ) consisted of three seminars on topics relevant to PA and cognitive impairment (“understanding cognitive decline,” “risk factors of cognitive decline,” and “physical activity as an effective intervention and safety security”). The educational sessions were offered for all participants in the community once a month.…”

Section: Methodsmentioning

confidence: 99%

Optimizing the physical activity intervention for older adults with mild cognitive impairment: a factorial randomized trial

Shao,

Huang,

Feng

et al. 2024

Front. Sports Act. Living

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BackgroundPhysical activity (PA) intervention is one of the most effective interventions to promote cognitive function of older adults with mild cognitive impairment (MCI). However, the level of PA remains low. Based on the two core interventions (X-CircuiT and health education), this study aimed to examine the effect of three implementation strategies (viz., role modeling, goal-setting, and reminding) on the PA level among older adults with MCI using the multiphase optimization strategy (MOST).MethodsParticipants were randomized into one of eight conditions in a factorial design involving three factors with two levels: (i) role modeling (on vs. off); (ii) goal-setting (on vs. off); and (iii) reminding (on vs. off). The primary outcome was PA level at 12 weeks. The secondary outcomes were cognitive function, self-efficacy, and cost-effectiveness at 12 weeks. The intention-to-treat (ITT) analysis was performed as the main analysis and the per-protocol (PP) analysis as the sensitivity analysis.ResultsA total of 107 participants were included and randomly assigned into three groups, each receiving different implementation strategies. The results of the multivariate regression analysis showed that the three implementation strategies, namely, reminding (B = 0.31, p < 0.01), role modeling (B = 0.21, p < 0.01), and goal-setting (B = 0.19, p < 0.01), could significantly improve PA level. Specifically, it was found that role modeling (B = 0.68, p = 0.03) could significantly improve cognitive function. There were no significant interactions among the three implementation strategies. Role modeling was the most cost-effective strategy, costing 93.41 RMB for one unit of PA.ConclusionsRole modeling was likely to be the best implementation strategy. The value-based and cost-effective PA intervention package could include the core intervention (X-CircuiT and health education) and implementation strategy (role modeling).Clinical Trial Registrationhttps://www.chictr.org.cn, The study was retrospectively registered on 30 June 2022 (ChiCTR2200061693).

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“…This study compared the effectiveness and acceptability of four different types of non-pharmacological interventions for MCI: physical activity, cognitive training, nutritional interventions and multicomponent interventions (which combine approaches) by conducting a systematic review (SR) of previous SRs 2. SRs were identified by searching seven databases (between June 2015 and June 2020).…”

Section: Methodsmentioning

confidence: 99%

Non-pharmacological treatments may improve cognition in mild cognitive impairment

Couch

2022

Evid Based Nurs

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Effectiveness and acceptability of non-pharmacological interventions in people with mild cognitive impairment: Overview of systematic reviews and network meta-analysis

Cited by 12 publications

References 34 publications

Long-lasting improvements in episodic memory among subjects with mild cognitive impairment who received transcranial direct current stimulation combined with cognitive treatment and telerehabilitation: a multicentre, randomized, active-controlled study

Long-lasting improvements in episodic memory among subjects with mild cognitive impairment who received transcranial direct current stimulation combined with cognitive treatment and telerehabilitation: a multicentre, randomized, active-controlled study

Optimizing the physical activity intervention for older adults with mild cognitive impairment: a factorial randomized trial

Non-pharmacological treatments may improve cognition in mild cognitive impairment

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