Effectively introducing a new meningococcal A conjugate vaccine in Africa: The Burkina Faso experience

Djingarey, Mamoudou Harouna; Barry, Rodrigue; Bonkoungou, Mete; Tiendrébéogo, S; Sebgo, Rene; Kandolo, Denis; Lingani, Clément; Préziosi, Marie-Pierre; Zuber, Patrick L. F.; Perea, William; Hugonnet, Stéphane; Tolve, Nora Dellepiane de Rey; Tévi-Bénissan, Carol; Clark, Thomas A.; Mayer, Leonard W.; Novak, Ryan T.; Messonier, Nancy E.; Berlier, M.; Toboe, Desire; Nshimirimana, Deo; Mihigo, Richard; Aguado, Teresa; Diomandé, Fabien; Kristiansen, Paul A.; Caugant, Dominique A.; LaForce, F. Marc

doi:10.1016/j.vaccine.2011.12.073

Cited by 92 publications

(93 citation statements)

References 9 publications

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“…The vaccine was introduced in December 2010, first in Burkina Faso (Djingarey et al, 2012) and in accordance with the last data more than 217 milion people in 15 countries have been vaccinated so far. The effects of mass vaccinations achieved so far are very promising.…”

Section: St-5ccmentioning

confidence: 58%

Significance of Meningococcal Hyperinvasive Clonal Complexes and Their Influence on Vaccines Development

Waśko¹,

Hryniewicz²,

Skoczyńska³

2015

Pol J Microbiol

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Neisseria meningitidis is a commensal of human nasopharynx and humans are the only known reservoir and host of this bacterium. It is also known as a dangerous and devastating pathogen, and infection with N. meningitidis may lead to rapidly progressing septicemia or meningitis. These severe infections, called invasive meningococcal disease (IMD), are one of the major public health threats worldwide. IMD may occur sporadically, but also in outbreaks, epidemics, and pandemics. Most of the IMD cases in the world are caused by isolates of genetically related groups, clonal complexes (CC), including those with special epidemiological significance called hyperinvasive clonal complexes. It is still unknown why some of them may persist for decades, whereas other are quickly replaced and disappear. As a consequence, the epidemiological situation of IMD is variable worldwide and greatly depends on the emergence and widespread of clones belonging to hyperinvasive clonal complexes. Their occurrence has serious implications for health policy, requiring often mass immunization campaigns. Paradoxically, alarming situations caused by hyperinvasive CCs stimulated the development and introduction of new vaccines against meningococci. Despite the unquestionable success of these vaccines, isolates of hyperinvasive clones constitute a permanent public health threat, because they are constantly circulating and able to modify their antigenic profiles to escape the host immune response. Therefore, continuous monitoring of meningococcal isolates including thorough molecular typing is indispensable and fundamental for taking appropriate preventive measures.

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Section: St-5ccmentioning

confidence: 58%

Significance of Meningococcal Hyperinvasive Clonal Complexes and Their Influence on Vaccines Development

Waśko¹,

Hryniewicz²,

Skoczyńska³

2015

Pol J Microbiol

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“…The Burkina Faso introduction was ideal; a well funded preparation on an infrastructure with strong laboratory based surveillance. 38 Hence, we do not think the Burkina results should be applied prospectively in all belt…”

Section: Disclosure Of Potential Conflicts Of Interestmentioning

confidence: 99%

Development of a group A meningococcal conjugate vaccine,MenAfriVac^TM

2012

Human Vaccines & Immunotherapeutics

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100

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“…Digitalization of public health laboratories have an intrinsic role in supporting surveillance activities, detection and identification of the organisms, conduct threat and outbreak inquiries, timely reporting and dissemination to all stakeholders as well as monitor and participatory response to existing or newly emerging infectious diseases and effective coverage management [20]. However, Africa remains challenged with the increasingly difficult for the public health laboratories to fulfill their missions on vulnerable populations [2,19,20].…”

Section: Setting Participatory Immunization Coverage Surveillance Andmentioning

confidence: 99%

“…However, Africa remains challenged with the increasingly difficult for the public health laboratories to fulfill their missions on vulnerable populations [2,19,20]. Moreover, increasing private health sector and independent laboratories consolidation, integration of clinical and digital information technologies in health systems delivery transformation is in progress in most African countries as an integral health development priority and economic growth.…”

Section: Setting Participatory Immunization Coverage Surveillance Andmentioning

confidence: 99%

Strengthening National Immunization Coverage Capacity and Effectiveness Strategies in Vaccine Preventable Diseases in Rural and Urban Settings in Sub-Saharan Africa

Tambo¹

2016

J Vaccines Vaccin

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Effectively introducing a new meningococcal A conjugate vaccine in Africa: The Burkina Faso experience

Cited by 92 publications

References 9 publications

Significance of Meningococcal Hyperinvasive Clonal Complexes and Their Influence on Vaccines Development

Significance of Meningococcal Hyperinvasive Clonal Complexes and Their Influence on Vaccines Development

Development of a group A meningococcal conjugate vaccine,MenAfriVac^TM

Strengthening National Immunization Coverage Capacity and Effectiveness Strategies in Vaccine Preventable Diseases in Rural and Urban Settings in Sub-Saharan Africa

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Effectively introducing a new meningococcal A conjugate vaccine in Africa: The Burkina Faso experience

Cited by 92 publications

References 9 publications

Significance of Meningococcal Hyperinvasive Clonal Complexes and Their Influence on Vaccines Development

Significance of Meningococcal Hyperinvasive Clonal Complexes and Their Influence on Vaccines Development

Development of a group A meningococcal conjugate vaccine,MenAfriVacTM

Strengthening National Immunization Coverage Capacity and Effectiveness Strategies in Vaccine Preventable Diseases in Rural and Urban Settings in Sub-Saharan Africa

Contact Info

Product

Resources

About

Development of a group A meningococcal conjugate vaccine,MenAfriVac^TM