Effective γδ T‐cell clinical therapies: current limitations and future perspectives for cancer immunotherapy
Isabella A Revesz,
Paul Joyce,
Lisa M Ebert
et al.
Abstract:Abstractγδ T cells are a unique subset of T lymphocytes, exhibiting features of both innate and adaptive immune cells and are involved with cancer immunosurveillance. They present an attractive alternative to conventional T cell‐based immunotherapy due, in large part, to their lack of major histocompatibility (MHC) restriction and ability to secrete high levels of cytokines with well‐known anti‐tumour functions. To date, clinical trials using γδ T cell‐based immunotherapy for a range of haematological and soli… Show more
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